New compound could give some types of cancer the one-two punch
...ancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cells from forming new blood vessels. Scientists are looking for alternatives to established anti-cancer drugs, such as Taxol, which is u...Emory researchers map structure of anti-cancer molecule
...tubulin, the protein loses its flexibility and the microtubules can no longer disassemble, halting cell division. To build the model, the Emory team used diffraction data gathered from an electron microscope at Lawrence Berkeley National Laboratory. The data allowed them to "see" the differences in the ...LICR/UCSD team solves mystery of centromeres
...aist in an "X". From opposite poles of the cell, microtubules called spindle fibers, extend down to the centromeres and act as ropes to pull the centromere and paired chromosome apart, so that half the centromere/chromosome moves to one side of the cell, while the other half goes to the opposite pole. Cell div...Sponge substance works well with yew derivative to thwart cancer cell proliferation
...t to stabilize the assembly/disassembly process of microtubules in cells. Microtubules--lengthy polymers made up o... drug binding sites normally associated with them, microtubules are unique receptors for drugs within cells. Paclitaxel is currently an approved therapeutic for co...Genetic model for devastating form of paraplegia suggests new treatments
...y a number of associated proteins. In nerve cells, microtubules carry cellular components to distant regions of th...rchers found that too much D-Spastin caused stable microtubules to disappear altogether. At the synapse, elevated levels of spastin also caused a large drop in syna...A genetic model for hereditary spastic paraplegia (HSP) disease
.... Through their interactions with other proteins, microtubules essentially represent the dynamic scaffolding of the nerve cell. In neurons, microtubules' responsibilities include carrying cellular components to distant regions of the cell, regulating the growth of neuronal branches, and providing a substrate fo...New designed paclitaxel analog kills more cancer cells than natural product
...hen paclitaxel binds to tubulin, it stabilizes the microtubules and messes up the equilibrium between tubulin and microtubule," said Kingston. "A cell with stable microtubules proceeds to programmed cell death without dividing." How does paclitaxel bind to tubulin? There is ...Cellular problems found behind complex obesity syndrome
... internal highway system -- a network of so-called microtubules along which tiny motors push and pull proteins, ce...stem disorders. "It's becoming very clear that microtubules are so fundamental to cells that if you hit the system with a genetic mutation you will get a diseas...New paclitaxel analog kills more cancer cells than natural product
...hen paclitaxel binds to tubulin, it stabilizes the microtubules and messes up the equilibrium between tubulin and microtubule," says Kingston. "A cell with stable microtubules proceeds to programmed cell death without dividing," How does paclitaxel bind to tubulin? There is a...UVa researchers describe method of protecting chromosomes during cell division
...it forms a spindle made up of thin polymers called microtubules extending from opposing sides of the cell. ...mes look alike. So, nature has devised a solution microtubules from one side of the cell must bind one chromatid, while microtubules from the other side bind the o...Scientists solve puzzle of how kinesin motor molecules walk or limp across cells
...d to treat breast cancer, works by stabilizing the microtubules that kinesins walk along and preventing them from de-polymerizing, Block noted. Recent studies also have shown that certain viruses, including smallpox and herpes, infect cells by hitching a ride on kinesin, added Adrian N. Fehr, a graduate student ...The beginning of the end of flagella
...e organism, and are made of nine double strands of microtubules and a central pair. According to Sloboda, similar IFT phenomena also take place in rod and cone cells of the human retina, in human kidney cells, and in nerve cells. To determine where EB1 occurs in Chlamydomonas cells, the researchers cloned and se...Anthony Hyman receives EMBO Gold Medal 2003
...PI-CBG seeks to understand the mechanisms by which microtubules perform these functions. The scientists use a wide...ook at understanding the interrelationship between microtubules and cell polarity during division of living cells. One key future issue will be to understand and in...New theory of cell death proposed in UCSB Alzheimers research
... ways to our own bones. However, unlike our bones, microtubules are dynamic structures, constantly growing and sho... control of the growing and shortening dynamics of microtubules is essential for cells to perform their many tasks and remain alive. In neuronal cells, a protein kn...Counting the molecules that pull cells apart
...uing lead. A cable-like network of proteins called microtubules tows freshly-copied DNA off to opposing sides of the cell. The identical sets of genetic material are then sealed off in their own cells. Normally the anchors that the tow-lines are attached to, called centrosomes, remain near the center of the cell....Counting the molecules that pull cells apart
...uing lead. A cable-like network of proteins called microtubules tows freshly-copied DNA off to opposing sides of the cell. The identical sets of genetic material are then sealed off in their own cells. Normally the anchors that the tow-lines are attached to, called centrosomes, remain near the center of the cell....Real-time imaging reveals the dynamic architecture of plant cells
...rs and hangs onto their ends. In plant cells, most microtubules are arranged quite differently. Instead of having...gie and Stanford University, determined where many microtubules originate and how some of them move around to become organized in epidermal cells. The results are ...Scientists observe nanosize microtubules 'treadmilling' across plant cells
...interest in cell growth, form and development, and microtubules play a prominent role in all three," said Stanford... Plant Biology located on the Stanford campus. The microtubules form specific patterns that determine the eventual shape of the cell and ultimately the shape of the...The mechanics of anti-tumor activity outlined
...rate that an agent, 2ME2, inhibits the assembly of microtubules in the tumors of treated animals," says Dr. Gianna...ncer, investigators showed that 2ME2 depolymerizes microtubules and blocks HIF-1a nuclear accumulation and HIF-transcriptional activity, or the transfer of genetic ...Promising new tool shows how dividing cells finish what they start
...identified a few of the molecular details that the microtubules use to signal the time and location of cleavage be...licated chromosomes apart. The signals between the microtubules and the cell membrane diverge into two pathways, one that signals myosin and a second unknown pathwa...