Muscle-repair defect underlies two muscular dystrophies
...e that would increase the activity of dysferlin in mild cases of various forms of muscular dystrophy. More broadly, said Campbell, the discovery opens a pathway to understanding of other muscular dystrophies, and in fact other muscle diseases. While the study of a disease led us to this identification of ...First peer-reviewed SARS genome sequence appears in Science
...t on the virus' origins. Known coronaviruses cause mild upper-respiratory illness in humans, in some cases, and a variety of diseases in other animals. While the SARS genome has the same overall structure as those of the three known classes of coronavirus, the researchers found key differences when they l...Gene discovery may shed light on carpel tunnel syndrome and Lou Gehrig's disease
...hromosomes. In most cases, CMT disease begins with mild symptoms, typically foot and ankle weakness and fatigue. As atrophy progresses, the patient develops a distinct walk, a consequence of muscle weakness in the front of the leg: the feet slap with each step and the body may sway from side to side. Ev...Premature birth linked to lack of nutrition before pregnancy: study
...after conception. Fifteen per cent is considered a mild to moderate nutrient restriction for sheep, says Bloomfield; after that time, nourishment levels were increased and ewes were allowed to eat as much as they desired. The normal gestational period for sheep is about 145 to 150 days. However, the resea...Science highlights of AAN Annual Meeting in Honolulu March 29 April 5
...inic in Rochester, Minn., showed that the risk for mild cognitive impairment (MCI) or Alzheimers disease could be predicted years in advance by a combination of factors, including age, presence of particular forms of the ApoE gene and performance on a battery of neuropsychological tests. Meanwhile, collea...DNA-based vaccine triples survival for dogs with melanoma
...y showed no side effects or toxicities with only a mild inflammatory reaction observed at the injection site. Two showed no evidence of disease when they were checked after completion of the vaccine regimen. Four dogs survived for over 400 days with the longest survivor still alive after more than 615 day...Study provides new insights into the functional neuroanatomy of motor imagery
...terest analyses from fMRI experiments often reveal mild activity increases in M1 during motor imagery, while group averaged analyses from fMRI and PET do not. Unfortunately, many of the fMRI studies showing M1 activity do not employ electrophysiological monitoring to exclude muscle contractions during a...Antibody therapy can increase the effectiveness of cancer vaccine, early studys
... itself, some of the melanoma patients developed a mild immune reaction against normal skin cells called melanocytes, but it was not a dangerous side effect. Previous clinical trials have shown that vaccines can be at least temporarily effective in treating metastatic melanoma and ovarian cancer, but mos...West Nile Virus cases analyzed for prevalence and symptoms
...e of an infected mosquito, is usually a relatively mild infection. It is estimated that about 20 percent of those infected will develop West Nile Fever, characterized by mild, flu-like symptoms, a skin rash on the trunk of the body and swollen lymph nodes. West Nile fever typically lasts only a few days a...Results from open-label Raptiva study suggest continued benefit with long-term treatment
...verall Lesion Severity scale) of clear, minimal or mild at week 12 were eligible to enter the continuous treatment period. Of the original 339 patients, 290 patients who met the entry criteria for the maintenance period entered the continuous treatment phase of the study. For each successive three-month...Why does caffeine delay exercise-induced fatigue?
...f the acclimation period. Gentle hand prodding and mild electric shock were combined to encourage the animals to run throughout the study. After the first two weeks of acclimation, rats assigned to the intracerebroventricular group were anesthetized with pentobarbital sodium, and tubes were implanted bil...Tips from the Journals of the American Society for Microbiology
...ntarum called pediocin. The authors did express a mild concern over an observation that in some cases listeria may become resistant. "The addition of a L. planatarum culture is a potent measure for combating listeria in a contaminated production line, but because of the potential development of resista...Horse owners should vaccinate horses, experts say
...In humans, West Nile infections usually cause only mild illnesses. Elderly and immunocompromised people are at increased risk of severe infection. There is no vaccine yet for humans. UC Davis mosquito-control experts also recommend controlling mosquitoes around horses (and homes) by removing unnecessary s...BIDMC researchers identify source of preeclampsia
...y develops after the 20th week of pregnancy and in mild cases, is characterized by high blood pressure, edema, and protein in the urine. In severe cases, the condition can rapidly develop into eclampsia, in which the mother suffers serious and potentially fatal seizures. "Currently, there is no treatmen...How postnatal experience influences brain development and brain function
...y in corticocosteroid regulation after exposure to mild stress in children with Fragile X syndrome. Greenough's latest findings on schizophrenia were announced at last year's annual meeting of the Society for Neuroscience. Greenough's doctoral student Ian M. Kodish announced that autopsies on deceased sc...Exercise and imaging tests predict heart events in high-risk families
...t 50 percent narrowed by plaque (the definition of mild heart disease). Of 30 siblings that had abnormal exercise tests and scintigrams, 70 percent had a blood vessel at least 50 percent narrowed by plaque, and 53 percent had a blood vessel at least 70 percent narrowed by plaque (the definition of sig...Newly developed tool aids study of Fragile X syndrome
...y in corticocosteroid regulation after exposure to mild stress in children with Fragile X syndrome. A reduced level of the glucocorticoid receptor, in the absence of the FMRP protein, Weiler said, would plausibly affect corticorsteroid feedback mechanisms, leading to prolonged levels of anxiety in Fragil...Using RNA interference to tune gene activity in stem cells
... knockdowns" can be used to create a full range of mild to severe phenotypes (something that geneticists dream about), as well as the potential of RNAi in developing stem cell-based and other therapeutic strategies. Along with a recent study by Hannon and his colleagues that demonstrated germline transmi...More people are getting sick from eating fresh fruits
...ne diseases can produce symptoms that run from the mild to life-threatening. The young and old are particularly vulnerable and while consumption of beef and poultry have been the most common sources of such infections, fresh fruits and vegetables are being increasingly implicated in such outbreaks. So muc...Female hormones found to protect against harmful effects of fructose
...s to develop in the female rats and was relatively mild compared with that seen in males. Whereas this is merely a qualitative comparison, it does suggest that there may be quantitative and duration-dependent differences between sexes in this response. Discussion The researchers suggest two possible exp...