Reexamining irons role in heart disease
...enerate a form that accumulates in cultured cells, mimicking the genesis of foam cells in the early atherosclerotic lesion. The potential importance of iron in atherogenesis has been suggested frequently, and some epidemiological evidence suggests that high serum iron levels can promote heart disease. Arguin...Novel, even unlikely drugs may curb childhood leukemia
...enic can trigger cancer cells to commit suicide by mimicking the normal developmental process of "apoptosis," or programmed cell death. -- A new type of leukemia drug, the bioengineered compound Glivec, can block the genetic signals that direct cancer cells to grow, while leaving normal cells largely unharme...Scientists track down the root of cloning problems
...very of extinct species, creation of animal models mimicking human diseases, and generation of herds of superior agricultural animals. The cloning procedure involves removing the nucleus, or the genetic command center, of an egg and replacing it with the nucleus of an adult cell. The egg resets the developme...UCSD researchers create a home for liver cells on a silicon chip
...ing. The porous silicon bioreactor design aids in mimicking the conditions found in liver. Individual cells are contained within well-like structures no wider than a human hair whose surface can be chemically modified to mimic the extracellular matrix distribution found in the liver. The porous nature of th...Controlling greenhouse gas carbon dioxide through carbon sequestration two-day symposium, April 2-3
...en into natural gas. This could be accomplished by mimicking natural geological and biological processes, according to David Beecy, director of the U.S. Department of Energy's Office of Environmental Systems. Such an approach is in its early days, but "the potential payoff is undeniably large," says Beecy. "Lo...New prime-boost HIV vaccine strategy shows promise in monkeys
...ter then kicks the immune system into high gear by mimicking a viral infection. The researchers hoped a combination regimen of the two vaccines would strengthen the immune system's ability to remember how SHIV looks and launch a rapid defense if infection occurred. The investigators vaccinated four groups of......the basis of a new discipline called biomimetics - mimicking nature. If you could give it marching orders, well... it just might make the perfect ground soldier. "And the fact that it could look like a scorpion," says Office of Naval Research Program Manager, Dr. Joel Davis, "would give it what every soldier i......ests. This created a condition of pre-Parkinsonism mimicking the early neurodegenerative state in the progression of Parkinson's disease. Treated and untreated rats were then given low doses of manganese. The manganese had no effect on dopamine levels in the substantia nigra, but caused significant impairment ...Antibiotics, yogurt seen as potential treatment for common liver disorder
... liver disease make too much of their own alcohol, mimicking what we see in fatty liver disease produced in humans who drink alcohol to excess," says Diehl. "Whenever the bowel fails to move normally, the partially digested food material becomes a food source for the intestinal bacteria. These bacteria overg......ffer the first demonstration that a small molecule mimicking a specific part of the NGF protein can activate the same key mechanisms in neurons that are activated by NGF, and in doing so prevent death of these neurons. Prior to this work, it was widely believed that the entire NGF protein was required to achi...Study on chromosome ends may aid cancer research
...e with telomerase. Zakian's research suggests that mimicking or enhancing the action of Pif1p may be a good way to do so. Telomerase builds structures called telomeres at the ends of chromosomes, like plastic caps at the ends of shoelaces. In normal conditions, telomeres shorten each time a cell divides, event...Cincinnati Children's researchers uncover critical food allergy pathway
...lergy and challenged the mice with oral allergens, mimicking food. This resulted in eosinophil accumulation in the blood and small intestine. In those mice genetically engineered without eotaxin, however, eosinophil recruitment into the small intestine was eliminated, while accumulation in the blood was enha...New theory on the mystery of the origin of life proposed by Weizmann Institute scientists
...red in the sequence of chemical units. Experiments mimicking the conditions on Earth billions of years ago have shown how such chemical units, e.g. some of the building blocks of proteins and RNA, could appear spontaneously. Yet, the emergence of proteins or self-replicating RNA molecules remained enigmatic. ...Blister beetles use sex and subterfuge to infiltrate bee's nests
...s flower, and female bolas spiders attract prey by mimicking the female sex pheromone of the armyworm. Dr. Ronald McGinley of the Smithsonian Institution's Department of Entomology says the findings raise "exciting questions" for future research. "How do newborn beetle larvae coordinate a collective pilgrimag...Oxidants play major role in healing of damaged blood vessels
...urface of the cultured cells, mimicking a wound to the endothelium similar to one caused by the accumulation of cholesterol. Then they measured the concentrations of endothelial cell oxidants both at the edge of the "wound" and...Researchers find key to growing, differentiating human cells
...eadily through the bioreactor, mimicking blood flow. In this latest work, the researchers found that enlarging or shrinking the gaps between the fibers in the bioreactor changes how the cells grow and develop. ...Nature's path leads scientists to new antibiotic strategy
MADISON - By mimicking one of nature's own potent antimicrobial defenses, scientists may have found a new way to wage war on pathogenic bacteria. Writing this week (April 6) in the British scientific journal Nature, a team of scientists from the University of Wisconsi...Guilt by association: Scientists nab suspects in prostate cancer
...derstood, Walker and colleagues reasonedthat genes mimicking the activity of PSA and other prostate cancer genes would themselves be likelyculprits in the disease. Following the trail, the researchers used a statistical method calledguilt-by-association to comb gene "libraries" for suspects activating in conj......attacks), and had decreased survival, thus closely mimicking human atherosclerosis and coronary heartdisease. "This research strongly suggests that elevated CETP may contribute to the development ofatherosclerosis in humans. It also substantiates a mechanism for the known epidemiological linkbetween increased...