Tag: "missing" at biology news
Brain Building May Depend On DNA Cutting And Pasting
...just after the critical period in normalbrains are missing
in those of mice without XRCC4 or ligase IV. "The next stepwould be to see if these genes in normal mice are associated with DNA breaks,"he says. He points out that the DNA breaks occurring during recombination in theimmune system do not occ...
UF Researchers: Gene Therapy Replaces Critical Protein In Animal Model Of Often-Fatal Lung-Liver Disease
...mploys a virus modified to incorporate the protein missing
inpeople with alpha-1-antitrypsin deficiency, which causes early emphysemaand severe liver disease. UF scientists injected the virus, known as theadeno-associated virus, into muscle tissue in mice, checking to see whetherthe protein would be secreted...
Large Gene Study Questions Cambrian Explosion
...icroscopic in size," Hedges says. "We seem to be missing
the fossils of a lotof species." Hedges says his research might be useful for finding life on other planets. "Ifwe can learn when different stages of life evolved on Earth, we can comparethose dates to events in the chemical evolution of Earth's a...
Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
...s the human cells couldsupply therapeutic proteins missing
in so-called single-gene-or evenmulti-gene-inherited brain diseases. Finally, the scientists found that the stemcells restored a brain area in mutant mice whose cerebellar granule neurons donot develop properly. In all those experiments, the...
Encouraging Results In Preclinical Studies Of Parkinson's Disease Gene Therapy
...nverted to dopamine, the neurotransmitter chemical missing
in these mice and in patients with Parkinson's disease. This work was published in the journal, Neuron, by a team of scientists led by Mark Szczypka, Ph.D. and Richard Palmiter, Ph.D. at the University of Washington and Ronald J. Mandel, Ph.D. and R...
Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
...m of the NAT1 gene, known as NAT1-10, and who were missing
the GSTM1 and GSTT1 genes, tended to develop colorectaltumors at a younger age. When the researchers looked at tumor location, they found that nearly half of patients with the NAT1-10 gene had distal tumors, which is significantly higher than the ty...
An Expedition Of Genetic Proportions Leads Duke Researcher To A New Culprit In Lung Cancer Metastasis
...ercent of thelung cancer tumors he has studied are missing
one copy of a certain region ofchromosome 11. Stud...indicate severity of the disease: Patients who are missing
one copy of the genecould be treated more aggressively since they would be more likely to develop,or...
Researchers Isolate Gene For Heart And Facial Defects
... variety of anomalies found inchildren known to be missing
a piece of chromosome 22 (22q11). Children w... is located on chromosome 22 in the region that is missing
in the22q11 deletion. Using molecular techniques, the researchers looked in mice to see where ...
Scientists Devise Method To Address Conflict Between Molecular Clock, Fossil Record Of Mammalian Evolution
...maintain that there are 65 million years offossils missing
from the history of modern placental mammals. This...e preservation in order to make this hypothesis of missing
time plausible."And it is not just the number of species that matters, but also their durationon Ear...
Study Finds Choline Deficiency Harms Memory Center In Mammals' Brains
...e take a folate supplement, for if this nutrientis missing
during early development the brain and spinal cord don't formcorrectly. The choline story now expands our recognition of how importantmother's diet really is."...
Research Reveals Environmental Injustice In N.C. Communities With Large Hog Farms
...ues had tocomplete geographic information that was missing
or incorrect for 257 hogoperations and excluded 67 that had closed, had insufficient data, didn't use aliquid waste management system or were owned by universities. They analyzed the remaining 2,514 hog farms in conjunction with data on4,177 ...
Scientists Discover Function For Type III TGF-Beta Receptor
...ptorsare found on the cells that transform but are missing
on the cells that do not." Transforming growth factor-beta (TGF-beta) has been suspected to play a role intransformation of the AV cushion cells, so Barnett and Christopher B. Brown,Ph.D. focused on the different types of TGF-beta receptors. In the c...
Story Tips: Engineering Students Pursue Cutting-Edge Research
...ates, leavingbehind DNA that may produce a protein missing
in the body. This could helprestore normal function to diseased cells. Using laboratory mice, Janes has been trying to trace where this corrective DNAsettles in thebody. If it is the liver, for example, that indicates this technique might beuseful fo...
The Chemical Leupeptin Protects Against Noise-Induced Hearing Loss In Animal Model, UB Hearing Researchers Show
...d with leupeptin, while only a few hair cells were missing
in thetreated ear. A similar study, designed to determine if leupeptin would protectagainst hair-cell loss caused by carboplatin, showed leupeptin offered noprotection, Salvi said. Additional researchers on the study were Jain Wan...
Jefferson Scientists Find Further Proof Of Damage To The FHIT Gene In Breast Cancers
...T in cancer cells could indicate that those with a missing
BRCA2 can'trepair DNA damage that occurs in FHIT. "One should look at other fragile sitesin BRCA2 and BRCA1 cases and probably in MLH1- and MSH2-associated tumors, whichare deficient in DNA repair mechanisms. Scientists would like to know what genesa...
UCSF Lab Makes Observation That Could Explain Ability Of Modified Cold Virus To Kill Cancer Cells
...But that when tumorcells with p53 genes intact are missing
p14ARF, p53 induction does not actuallyoccur." "We...mal p53 genes." "We're trying to prove this is the missing
link in the lab, by putting p14ARFback into these tumor cells and seeing if it really does stop the ...
Study Suggests New Approach To Asthma
...thelial immune-responsegenes helps explain several missing
pieces of the asthma story." In this regard, Holtzman says, the findings offer the first example linkingabnormal behavior of JAK/STAT pathways for cytokine signaling to the developmentof an inflammatory disease. Activation of the JAK/STAT pathway ap...
Important Genetic Marker For Alzheimer's Disease Questioned
...Disease. The nextstep will be to try and find that missing
gene," said Professor Peter St.George-Hyslop, director of the Centre for Research in Neurodegenerative Diseasesat U of T. "We think it's pretty clear that the search for the chromosome 12 Alzheimer'sgene must continue. There are several other genes i...
Studies Of A Gene For A Rare Form Of Rickets Shed Light On Vitamin D Deficiencies
...ment amounts of the active hormone." Replacing the missing
vitamin D hormone is a solution for most children, Portalesaid: "The rickets begin to heal, the bone deformities improve, the bloodchemical values return to normal. And the child begins to grow more normally." Of the 19 people that Miller and Portale...
Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
...hat DAF-16activity was needed in order for animals missing
their germ lines to have longlifespans. In other ...ed twice as long as the already long-lived animals missing
DAF-2,which is four times as long as normal. The researchers reasoned that if thegerm cells worked ...
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