1st evidence that nuclear transplantation ('therapeutic cloning') can eliminate tissue rejection
...cted in cattle despite the presence of the foreign mitochondrial DNA. The immune system in cattle is relatively complex; therefore, these "preclinical" studies suggest human applications may be possible. In addition to creating skeletal muscle and heart 'patches,' nuclear transplantation was used to generate immu...Drug wrecks the power plants of cancer cells
...F16, they become swollen, and eventually the outer mitochondrial membrane ruptures," she said. "And when we looked at markers of apoptosis like cytochrome c release, we could see clear evidence of such release in F16-affected cells." According to Leder, F16 and perhaps other related compounds have properties that ...Nerve cells' death different from other cells'
...chondria. "This study links PARP activation with mitochondrial function for the first time," says Dawson. "We thought AIF was a good candidate for that link, and we've shown that it's required for cell death after PARP activation, and conversely that PARP activation is required for its release from the mitochond...Scientists discover genetic defect responsible for microcephaly
...believe that without this carrying ability, called mitochondrial deoxynucleotide transport, the cell's mitochondria...lop abnormally. The NHGRI data also indicate that mitochondrial deoxynucleotide transport may play a crucial role in normal prenatal brain growth. "It's a signific...Study suggests coenzyme Q10 slows functional decline in Parkinsons disease
...mitochondria from PD patients are reduced and that mitochondrial function in these patients is impaired. Animal studies have shown that coenzyme Q10 can protect the area of the brain that is damaged in PD. Dr. Shults and colleagues also conducted a pilot study with PD patients which showed that consumption of up...Scientists discover ancient protein and DNA sequences in the same fossil
...ingle fossil bone. In addition to the recovery of mitochondrial DNA, the complete sequencing of a bone protein, os...ting. The Siberian fossil ultimately revealed both mitochondrial DNA and a complete sequence of osteocalcin, a protein found in all bones that is involved in bone fo...Once big bad wolf, now man's best friend: Science studies trace dogs' origins
...studied genetic sequences that came from the dogs' mitochondrial DNA, which, unlike the DNA in the cell nucleus, is inherited directly from the mother. The scientists looked specifically at the "control region," a stretch of DNA known to accumulate mutations relatively quickly, making it a good place to look for d...UC Berkeley, Joint Genome Institute target chloroplasts for clues to green plant evolution
...lement of genes distinct from the comparably sized mitochondrial genome in the energy center of the cell or the muc...e nuclear genome, and easier to analyze than plant mitochondrial DNA," said Brent Mishler, professor of integrative biology at the University of California, Berkeley...West Nile Virus capsid protein causes encephalitic inflammation by triggering cell suicide
...ptosis in cell cultures through what is called the mitochondrial pathway. The protein begins the process of cell suicide by somehow disrupting the membrane potential of the cell's mitochondria, which then leads to the activation of proteins such as caspase-9 and caspase-3 that start a cascade of reactions to subse...European scholars support development of germ line modification
... context of IGM. A form of IGM already occurs when mitochondrial genetic defects are treated within the context of in vitro fertilization with cell nuclear transfer or exchanges of cytoplasm. The possibility cannot be ruled out that inadvertent inheritable genetic modification may already occur at a low level in s...UT Southwestern researchers develop new model for understanding obesity, diabetes
...logy." Two of these genes encode components of the mitochondrial respiratory chain (biochemical processes in the mi...lation was markedly reduced. Gene mutations in the mitochondrial respiratory chain already have been linked to abnormalities in fat accumulation in humans, including...International team uses genomic tools to discover gene for childhood genetic disorder
.... Armed with a clue that the culprit is related to mitochondrial function, the scientists searched for leads in thr...ian postdoctoral fellow of Lander and an expert on mitochondrial biology, asked to tackle the problem by applying the new tools of genomics. Using a three-pronged a...JCI table of contents, January 15 2003
...re targeted to the mitochondria. Theyconclude that mitochondrial targeting of glycosphingolipids is likely to bethe key event that sets off the apoptotic cascade. CONTACT: Jose Fernndez-Checa Hospital Clinic i Provincial Instituto Investigaciones Biomdicas IDIBAPS Consejo Superior Investigaciones Cientificas Villa...Fox Chase Cancer Center researchers make significant discovery about function of p53
... of how this protein kills cells. By bringing the mitochondrial pathway of cell death to the forefront of research, the investigators suggest that drugs could be designed to put p53 directly into the mitochondria or enable the cell to put it there. In the paper, they begin to test this hypothesis. They showed tha...Study shows how eye cells die when exposed to lead
...death of the eye's rod cells and maintained normal mitochondrial function in the rods throughout adulthood. "All cells produce anti-death proteins like Bcl-xL, and normally when they combine with Bax, it prevents Bax from triggering cell death. Too much Bax results in cell death," Fox says. "But these transgenic ...JCI table of contents, March 3, 2003
...illations,which in turn increased the amplitude of mitochondrial Ca2+ oscillations andthe production of reactive ox...ould beinhibited by antioxidants and inhibitors of mitochondrial metabolism,demonstrating that mitochondria are the organelles that couple themechanical effects of h......his studies in the intensively-researched field of mitochondrial biogenesis, Roland Lill has discovered a completely new facet of the mitochondrial function. With the help of his study group he has discovered that mitochondria are essential for the...Genetic risk factor for Parkinson disease discovered
...g Parkinson's disease. The scientists examined the mitochondrial DNA of 609 Parkinson's disease patients and 340 normal controls who had no signs of the disease. In particular, they looked at nine well-known and well-studied gene variations that vary among ethnic groups. When they looked at the correlation between...Study says: 'whey' to greater muscle strength is through training and protein supplements
... (P<0.05) increased levels of muscle force and mitochondrial energy production in rats as well producing significantly better (P<0.05) improvements in strength and body composition in bodybuilders during resistance training. Now, these scientists lead by Prof. Mick Carey and Dr Alan Hayes at the Centre fo...Alzheimer's protein jams mitochondria of affected cells; resulting 'energy crisis' kills neurons
...while traversing protein transport channels in the mitochondrial membrane. This hampers, and eventually completely...ve diseases, the scientists said. As pores in the mitochondrial membrane clog with proteins -- inaccessible to enzymes that might normally degrade them -- cellular ...