Tag: "mitotic" at biology news

Scientists Identify A Novel Mitotic Regulatory Mechanism

...lts of the research teams suggest regulation of mitotic progression via a novel mechanism involving bin...l-prolyl cis/trans isomerase) to phosphorylated mitotic proteins and catalyzing a conformational change of these binding partners thereby allowing the...

Harvard Medical School Researchers Identify Four Human Genes Essential To Cell Division; Discovery Yields New Target For Cancer Therapies

...- the second cycle. The APC is one of the mitotic ringleaders. "It is absolutely requiredfor cell proliferation," says Yu. The protein complex drives a dividing cellfrom the metaphase stage of mitosis into anaphase--from the point in which thechromosomes find their partner and gather in pairs in the...

Harvard Medical School researchers discover first in a new class of mitosis inhibitors

...n tubes that are the mainstructural element of the mitotic spindle. The paper demonstrates that it is...ng monastrol to study the moleculardynamics of the mitotic spindle, a finely tuned structure that separates the twosets of chromosomes during cell division. At...

Pitt team first to illustrate mechanisms of chromosome missegregation in cancer cells

...otein within each spindle pole, called the nuclear mitotic apparatus protein (NuMA), split apart in renegade ...or years, scientists have recognized these bizarre mitotic spindle structures in pathology specimens, and we've known for some time that NuMA is involved in ...

New gene monitors cell division, cancer clinical applications seen

...he frequency of mutations in previously identified mitotic checkpoint genes is too low to explain the inciden...ts and died. Prior to the current study, the known mitotic checkpoints monitored the proper completion of metaphase before allowing the process to proceed to a...

A molecular motor's key role in cell birth

...quences for new cell formation. The new model for mitotic mechanics, as reported in the latest issue of the ... four authors of the report ("Myosin V orients the mitotic spindle in yeast"). "We found the protein Myo2p works as a molecular motor by walking along oriente...

Scientists find that heart muscle cells regenerate after a heart attack

...vision. The scientists also obtained images of mitotic division and found other evidence of myoctye repli...dence of myocardial repair was demonstrated by the mitotic index, a measurement of the degree of myocyte division. In comparison with normal hearts, the numb...

A closer look at the genomes black holes

...apidly evolving DNA. Normally, the elements of the mitotic segregation machinery would be expected to be highly conserved, as are other essential cellular machines, such as ribosomes. But the central question with centromeric DNA is why it hasn't found some optimal sequence and just stayed there. A key to st...

UCSD biologists discover that machinery for cell division plays dual role in partitioning developing embryo

...of the PAR-3 and PAR-2 proteins (in red), with the mitotic spindle (in green) displaced toward the PAR-2 end....the cell splits into two equal sized cells and the mitotic spindle remains at the center. Besides providing developmental biologists with a better understandi...

What inspires yeast cells to divide?

...llator controlled chromosome separation as well as mitotic exit via elimination of Clb5, while the Cdh1 oscil...t the elimination of Clb5 can act as a trigger for mitotic exit under experimental conditions. But we now know that the essential trigger is the direct destruc...

Chromatin, not proteins, support chromosomes during cell division

...are tightly condensed into durable packages called mitotic chromosomes. These chromosomes must survive the tr...ovides this support. "What we've shown is that the mitotic form of chromosomes, when they're folded up for transmission during cell division -- the long, chrom...

Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize

...several mutants within a group of genes called the mitotic exit network (MEN), Shou concluded that MEN controls the end of cell division by transmitting a signal to dismantle a protein complex dubbed RENT, which keeps the cell from ending mitosis prematurely. Shou, now at Rockefeller University, submitted tw...

Children's Hospital Boston researchers regenerate zebrafish heart muscle

...afish with a genetic mutation affecting the enzyme mitotic checkpoint kinase (Mps1) no longer had rapid heart-cell formation and lost their ability to regenerate heart muscle. Instead, they had muscle scarring, as humans do. However, Keating emphasized this mutation is not necessarily the mechanism that inhi...

Zebrafish may point the way to mending a broken heart

...h with a mutation in Mps1 , a gene that encodes a mitotic checkpoint kinase protein critical in cells that regenerate zebrafish fins. At temperatures above 33 degrees Celsius the mutant form of Mps1 can no longer function properly and the cells stop proliferating. When the temperature is raised to that leve...

Mathematical prediction of on-off switches in cell division proven

...ures that Cdc2 is irreversibly turned ON or OFF at mitotic entry and exit, respectively? Does the switch function like a buzzer or a toggle? "A buzzer is ON when one pushes hard enough on its button and stops buzzing when one lets go. A toggle likewise switches on when one pushes hard enough on the lever i...

Physics tip sheet #34 - April 1, 2003

...y and efficiency of individual treatments. However mitotic strategies cause a distinct change in the patterns of tumor growth. The types of changes seen are similar to when bacterial colonies exposed to non-lethal concentrations of antibiotics exhibit drastic changes in their growth patterns. Seeing as this ...

Failures in primate cloning may signal impossibility of human reproductive cloning

...he key structures involved in cell division is the mitotic spindle, which functions to precisely align and separate chromosomes. However, in cells originating as a result of nuclear-transfer, examination of spindle configuration revealed chaotic structures and unequal chromosome counts. Even the most basic p...

Anthony Hyman receives EMBO Gold Medal 2003

...s of microtubule polymers and the formation of the mitotic spindle, the structure that segregates the chromosomes at mitosis. They also look at understanding the interrelationship between microtubules and cell polarity during division of living cells. One key future issue will be to understand and investigat...

Grant renews funding of research toward cloning primates

...he key structures involved in cell division is the mitotic spindle, which functions to precisely align and separate chromosomes. However, in cells originating as a result of nuclear-transfer, examination of spindle configuration revealed chaotic structures and unequal chromosome counts. Even the most basic p...

Circadian clock genes may provide targets for new cancer drugs

...] circadian cycle," the team reported. The tumor mitotic index, a measure of the proportion of cancer cells actively dividing, was also most prominent during the activity phase of the circadian cycle. The scientists then analyzed the expression of circadian clock genes in tumor cells and in normal (liv...

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