Gene therapy holds promise for treating inherited Lou Gehrig's Disease
...ase and to choose theappropriate target tissue and mode of gene delivery," Bohn said. The mice used in this study express a mutant gene that is carried byhumans with a hereditary form of ALS. These mice were developed by Mark Gurneyand Teepu Siddique, professor of neurology at Northwestern Univers...Researcher finds plant toxin that causes fungal suicide
...mbranes and made them leak. This part of osmotin's mode of action wasn't too surprising, because many otherdisease-fighting compounds act similarly in plants. But osmotin did more thanchew holes in membranes. It also altered the protein-generating machinery of the fungal cells, causingthe fungus to build ......ons canbe made. A concept for a new type of single mode optical fiber with the potential for crosssectional areas of the same size as multi-mode fibers has recently been reported. The useof this type of fiber would permit the focusing down of the laser light into much smallervolumes which implies that las...DFG to set up 21 new collaborative research centres in 2000
...signals over this barrier and so provide a natural mode of cell regulation. The collaborative research centre "Regulatory Membrane Proteins. From the Mechanism of Identification to the Pharmacological Target Structure" at Wrzburg University is to investigate these switching points. As potential pharmacolo...Team led by MSU biologist finds bacteria deep in Antarctic ice
...said. "If alive, I think they are in a maintenance mode of metabolism,rather than one of active growth." Priscu and his teams have found microbes growing in other Antarctic frozen lakes, butnone nearly as deep as Lake Vostok. Microbes are known to hang out in other extreme environments,such as hot vent...Sexual fantasies increase pain tolerance
...physicians used the power of suggestion as a major mode of treatment. Now we're sopressed for time that we don't always have a chance to really converse with patients, to listen totheir fears and anxieties. Whether patients think positive thoughts themselves or whether you saypositive things to them, it...X-rays may show way to better Alzheimer's drugs
... neuronal function," says Greenblatt. "This dual mode of action, coupled with the evidence that galantha... common denominator. Although they differ in their mode of association, they inhibit AChE by blocking its active site located at the bottom of the aroma......ction in living systems. It will help to study the mode of action of individual peptides in contact with the cell membrane as well as the mechanical response of cells to external mechanical disturbances. Dr. Karsten Weihe (32), University of Constance, Mathematics and Computer Science Department Karsten W...Revised model of protein-drug interactions could make job of drug designers a little easier
...g. "We usually thought there was only one binding mode at an active site of a protein," said Mesecar. "This shows you can have at least two. Selection is dependent on the active site environment of the protein." This new way of looking at protein interactions would significantly affect drug designers, w...Low blood levels of HIV reduce risk of heterosexual transmission
...ions of HIV-1 worldwide, and it is the predominant mode of transmission in sub-Saharan Africa. It is also increasing throughout Asia and in many industrialized countries. In an effort to better identify risk factors for heterosexual HIV transmission, the scientists followed 415 couples in which only on...Blister beetles use sex and subterfuge to infiltrate bee's nests
...o shame. In what researchers say is a "remarkable mode of host-finding," newborn blister beetle larvae of the species Meloe franciscanus mimic female bees as part of a three-step strategy to infiltrate and parasitize the bee's nest. Blister beetles pull off their charade much the same way human performer...June 'Geology' and 'GSA Today' highlights
...th Dakota Peter M. Sheehan et al., p. 523 The mode of dinosaur extinction has long been contentious. One camp argues that dinosaurs went extinct suddenly (as would have occurred if an asteroid killed them), while the other argues that the dinosaurs went extinct gradually (as would have occurred if a...Researchers decipher fundamental signal for maleness
...t face of DNA, called the minor groove. This novel mode of binding permits coordinate control of genetic elements in the fly's DNA to combine sex-specific signals with other signals indicating where in the body the target gene is to be turned on or off, and at what stage of development. "Being able to i...Canine leishmaniasis cases are confirmed in 21 states
...smission by insects like sand flies or ticks. That mode of transmission, Breitschwerdt says, could create a public health concern. Leishmaniasis is a parasitic infection and most often occurs in rural areas of the tropics and subtropics, where the most common species of the parasite is transmitted by...MS clinical trials confirm approach, demonstrate need to carefully refine targeted peptide therapy
...hers to this therapy and what dose, frequency, and mode of administration provide the best results. More carefully controlled clinical trials of this or similar therapies should eventually reveal the answers to these questions....Ancient running reptile was bipedal, say Science researchers
...ains a wealth of clues about the reptile's unusual mode of locomotion. Its skeletal features suggest that the reptile could move swiftly on two legs, probably up on its toes, using an upright posture with the limbs moving pendulum-like and parallel to the long axis of the body. This is similar to the post...Colorado U. study indicates Denver area drivers unmoved by state air quality advisories
... single-occupant commuters said they changed their mode of transportation under red advisories only if it was convenient. Many responders reported they had no alternate means of transportation or that methods such as public transit were too inconvenient. The CU-Boulder study was recently accepted for p...Common mode of action likely in gene-activation molecules linked to cancers
...es, suggesting the molecules likely share a common mode of action, whatever their chemical dissimilarities. The new findings are reported in the November issue of Molecular Cell, to be published November 17. The ability to turn genes on and off appropriately is key to normal function in all cells, and ...Finding could lead to new approach for treating severe heart disease
... the adeno-associated viral vector may be an ideal mode for delivering the VEGF gene into the heart muscle," says the lead author of the study, Hua Su, MD, assistant research physician in the UCSF Cardiovascular Research Institute and a member of the UCSF laboratory of senior author Yuet Wai Kan, MD, DSc,......cal features of the diseaseincluding age of onset, mode of inheritance, frequency, severity, extent of tissue involvement and association with malformations. The analysis yielded a number of striking general insights, said Valle. For example, the scientists found that genes that encoded transcription fac...