JCI table of contents, 17 May 2004
...alpha-secretase. In these studies, they find that moderate increased expression of ADAM10 in mice reduced AB peptide formation, prevented plaque formation, and, from a functional standpoint provided improvement in both long-term potentiation and cognitive impairment. On the other hand, mice lacking ADAM10 h...Data show investigational antibiotic safe, effective in preventing travelers diarrhea
... forms of diarrhea and prevented the occurrence of moderate and severe abdominal pain and cramps and excessive gas-related symptoms. The drug was safe, having in incidence of adverse events comparable to placebo (inactive sugar pill used to blind the drug). For a copy of the DDW abstract or for more informa...Moderate alcohol consumption increases plasma levels of a protective hormone
...estosterone and estradiol. Researchers found that moderate alcohol consumption can increase plasma DHEAS leve...iet-controlled intervention study which shows that moderate alcohol drinking can increase DHEAS," he added. "Estradiol, or estrogens in general," Hendriks conti...Nonalcoholic beverages may impart cardiovascular benefits without the negative effects of alcohol
...sease. Research on the cardiovascular benefits of moderate alcohol consumption has shown that alcohol's prote... also its nonalcoholic constituents. For example, moderate drinking may lower the risk for coronary heart disease (CHD) through alteration of an individual's...Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
...fficacy and safety of Tectin TM versus placebo in moderate to severe inadequately controlled cancer-related pain. The study is being led by two nationally respected leaders in cancer pain assessment and management, Dr. Neil Hagen, Head of the Division of Palliative Medicine, Department of Oncology at the Uni...Researchers string together players in pesticide resistance orchestra
...two species native to the United States that cause moderate to severe damage to fruits, vegetables, tree seedlings, cotton and alfalfa. The total annual losses and control costs attributed to this one insect are $2.1 billion to $3.5 billion, according to the U.S. Department of Agriculture's Agricultural Resea...New research outlines public health consequences
... of smoke exposure, and in 8 percent of those with moderate exposure. "We believe the high alkalinity of the dust was a major contributing factor to the high incidence of bronchial hyperreactivity," said Landrigan. Among ironworkers involved in clean-up and recovery, many of whom spent several months in an...Animal studies show promise treating severe chronic pain
...analgesics, the mainstay of current treatments for moderate to severe chronic pain, cannot provide universal relief, and other treatments are nonselective and/or can cause serious side effects. Iadarola said this month's paper stems from using the old drug resiniferatoxin, or RTX, in a new way. First isola...Longer-term, moderate exercise improves immune activity
Older men and women who performed moderate resistance exercise at home 30 minutes a day, thre...5), all retired. They then were trained in simple, moderate intensity resistance exercises, involving tubing and exercise balls, which they could do alone at ho...Is a single bout of exercise helpful or harmful in getting a good night's sleep?
...er the various exercise conditions (i.e., high and moderate volume resistance and aerobic exercise) when compared to the no exercise condition. Volunteers also reported waking up significantly more times at night after exercise (regardless of the type of exercise) compared to before the exercise condition. ...Exercise reduces blood estrogens, risk for breast cancer in post menopausal women
Three hours of moderate exercise per week significantly reduced circulating estrogens in postmenopausal women, according to a new study published in the current issue of Cancer Research. The finding may explain why women who exercise regularly lower their risk for breast ca...Specifying alcohol-related brain-damage among heavy social drinkers
...on't overdue it.'" He added that for most adults, moderate alcohol use up to two drinks per day for men, and one drink per day for women and older people causes few if any problems. ...Genetic basis of hereditary nerve disorder revealed
...ents with the disease include physical therapy and moderate activity to maintain muscle strength. Patients often rely on leg braces and, in some cases, become wheelchair-dependent. While defects in multiple genes are known to underlie various forms of CMT, the current finding uncovers a whole new mechanism of...Sickle cell sufferers living longer, dying less from their disease
...still have no way of knowing who will have severe, moderate or mild forms of the disease until complications occur, Dr. Quinn said. Discovering risk factors can help a physician develop the best treatment and match the risk of treatments to the risk of the disease. "The next step is trying to capture a...Alcohol consumption can damage hearing
...ive life-long alcohol consumption than do those of moderate and heavy drinkers. "The finding of this article d...rs' hearing is at more risk of damage than that of moderate and heavy drinkers," said Tilman Keck, assistant clinical professor in the department of Otorhinolar...Lakes with zebra mussels have higher levels of toxins, MSU research finds
...increase in toxic Microcystis in lakes with low to moderate levels of phosphorus, anywhere between 10 and 25 micrograms per liter. Such lakes are not normally expected to have very many blue-green algae, Sarnelle said. "Our data suggest that zebra mussels promote Microcystis at low to medium phosphorous level...New map predicts where wolves will attack
...c. The map revealed that southwest Wisconsin faced moderate to high risk, an area where breeding packs of wolves have not yet recolonized. The map also revealed that highest risk townships were clustered along the edge of the wolf population--areas with the lowest habitat suitability for wolves and where new...Mix of chemicals plus stress damages brain, liver in animals and likely in humans
...es for 28 days. "But when we put the animals under moderate stress by simply restricting their movement in a plastic holder for five minutes at a time every day, the animals experienced enough stress that it intensified the effects of the chemicals dramatically," said Abou Donia. Soldiers in the Gulf War were...Schering-Plough scientists identify protein essential for cholesterol absorption from intestine
...ts of increased exposure to ZETIA in patients with moderate or severe hepatic insufficiency, ZETIA is not recommended in these patients. In clinical trials, there was no increased incidence of myopathy or rhabdomyolysis associated with ZETIA; however myopathy and rhabdomyolysis are known adverse reactions to...Breakthroughs in acoustic tracking shine new light on the lives of fish
... fishery catches. As the population increases to moderate size, marine reserves can be used to increase egg production and maintain fishery catch. With robust populations a system of marine reserves can increase egg production and fishery yield by allowing higher fishing rates outside the reserve than would...