Tag: "modification" at biology news
Statins' beneficial effects on HDL
...ns. In particular, they are required for the lipid modification
(geranylgeranylation) of the Rho family of protein kinases. Martin et al. define the outlines of a pathway whereby geranylgeranylated RhoA suppresses PPARa activity. By blocking mevalonate synthesis, statins apparently derepress PPARa and thereby act...
Reexamining irons role in heart disease
...osclerotic plaques, but the nature of the chemical modification
that converts native LDL to an atherogenic species in vivo is a matter of much debate. LDL can be oxidized in vitro by treatment with iron or other metal ions to generate a form that accumulates in cultured cells, mimicking the genesis of foam cells ...
July media highlights: GEOLOGY and GSA TODAY
... strong environmental mechanisms for rapid habitat modification
and coral extinction. They suggest what might be expected in reef environments, as sea level and temperature fluctuate on short timescales, such as may be occurring as a result of human activity. Archeological implications of the geology and chronol...
Dietary approaches to stop hypertension diet reduces cholesterol and long-term cardiovascular risk
... by Blackburn cautions that the extent of behavior modification
that would be required to adopt a diet with twice the volume of healthful food in the typical American diet could be prohibitive, whereas "those who make small, incremental changes in their diet over time have the highest probability of success."...
UCSD biologists identify genetic mechanism conferring resistance to 'Bt toxins'
...old that is predicted to bind precisely the sugar modification
made by the galactosyltransferase, raising the possibility that this mechanism of resistance could be widespread. The discovery that the loss of a general modifier like a galactosyltransferase can allow an organism to develop resistance to Bt toxi...
New model of staph drug resistance implicates unlikely protein
... The development of new antibiotics along with the modification
of old ones is of utmost importance....
Discovery of a unique gene modification may provide clues to the cause of certain types of lymphoma, UCLA researchers say
...onsson Cancer Center have discovered a unique gene modification
in adult human cancer cells that could provide ins...s of development may be using this new type of DNA modification
to accomplish this reversion, Teitell said. The cancer cells stop utilizing the genes for differenti...
Science steps up on International Space Station with new experiments, fresh crew to operate them
...halls Flight Projects Directorate. This innovative modification
of existing hardware will make it possible to fly additional, low-cost science payloads in the Shuttle, or deliver replacement parts quickly to the Space Station. During Expedition Four, the suite of research instruments will grow from 18 to 26 U.S....
Women more susceptible to orthostatic hypotension
...rent sensitivity or in the central integration and modification
of reflex input signals. Sensory signals contributing to the HUT sympathetic response arise from cardiac chambers, aortic and carotid structures, and from vestibular receptors. Otolithic vestibular afferents appear to contribute to the orthostatic sy...
MPO generates nitrotyrosine in the subendothelial space
...eresting example of a pathological form of protein modification
occurring outside the cell. Vascular ECM component...al. note, the mechanism of this post-translational modification
and the basis of its localization have been uncertain. Striking images in their present report show ...
Fish may show how nature diversifies
...d reveal a flexible genetic system for independent modification
of the size and number of different feeding and armor structures, the authors report. But perhaps more important, said Kingsley, is the creation of a resource that will help bring together a large body of ecological work with the tools of modern geno...
Protein discovery tied to DNA master switch
...y focused their attention on a particular covalent modification
-- methylation, addition of a methyl group to lysi...w the identity of the enzymes responsible for this modification
until a year ago when the first lysine 9-specific histone methyltransferase was identified," Zhang s...
US researchers successfully clone first knockout miniature swine
...hed Professor of Reproductive Biotechnology. This modification
eliminates the gene that triggers this response, o...begin. Todays report represents the first targeted modification
of the pig genome and only the second in any large animal. It also is the first nuclear transfer-der...
Genes in women who smoke linked to prematurity, low birthweight in their babies
...two genes that normally control the bodys chemical modification
of components of cigarette smoke were missing or inactive. The authors also note that 65 percent of all infant deaths in the United States occur among low birthweight infants (5.5 pounds or less). This is the first study to demonstrate a link betwee...
UT Southwestern space researchers pinpoint mechanism involved in loss of consciousness after space flight
...bility and expand the blood volume and behavioral modification
to facilitate return of blood back to the heart has helped more than approximately 75 percent of patients who present to our autonomic function clinic with symptoms of orthostatic intolerance, said Levine, who is medical director of the Institute for...
Study shows plants inherit traits from more than gene sequence alone
...in DNA methylation. DNA methylation is a chemical modification
of cytosine, one of the four chemical subunits of ... in mice. But methylation is just one type of DNA modification
studied in epigenetics. There are several others. The next level of gene regulation studied in epig...
New light on molecular switch that turns genes off
...t regulate gene expression. Among the biochemical modification
mechanisms that can dynamically change chromatin's...ening or tightening - is histone methylation. This modification
mainly occurs on lysine residues, one of the amino acids that comprise the tail region of histone mo...
Wheat may be vital in battle against cancer and other diseases
...eat with high levels of orthophenols. A successful modification
could lead to wheat's ability to combat cancer by simply including it in a daily diet. K-State scientists are optimistic of wheat's cancer-fighting ability because their preliminary testing shows some available wheat strains already contain a great n...
Purdue to help NASA create life-supporting ecosystem in space
...e photosynthetic pigments in the plants. This is a modification
of the commercial 'pathlights' you see in movie theaters and in airline exit rows." Researchers are studying about 15 crops for possible use in the advanced life support system. The work will address a range of issues. "How are we going to store food...
Scientists find protein at the intersection of genetics, development, and environment
...raits that might provide an alternative to genetic modification
of crops, researchers report in the journal Nature. They have linked this phenomenon to the actions of a particular molecule, the heat stress protein Hsp90. These findings place Hsp90 at the interface of environment and genetics and potentially pro...
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