Fewer calories linked to healthier brains in old age
...the development of interventions -- drugs, dietary modifications -- to retard aging in the brain." Prolla says the study also indicates that diet alterations may lower the risk of developing some of the most common and debilitating age-associated neurological disorders. The Wisconsin study depended on a powerful n...First gene therapy to calm pigs' out-of-sync hearts
...thods no open chest, no contrivances, just simple modifications of existing technology," says Eduardo Marban, M.D., Ph.D., one of the scientists. "This is the first proof-of-concept work," says Marban, "and the first clear step toward a clinically useful approach." A report of the research appears in the Decembe...NHLBI study shows reduced fat intake to lower cholesterol is safe and beneficial for children
...ower levels for several more years. These dietary modifications did not alter the children's growth, nutritional s...development, we can measure the effects of dietary modifications in the context of physiological changes during puberty."DISC was conducted at six medical centers an...Zebrafish could become genetics 'lab rat' of choice
... a technique that allows zebrafish to pass genetic modifications to its offspring. The discovery will lead to researchers being able to study genes and proteins in a less expensive way. The two-inch, black-striped zebrafish known primarily as the last fish living in your kid's aquarium is quickly becoming famous...Older fathers more likely to have children with schizophrenia
... Second, researchers can focus on identifying gene modifications in cases of advanced paternal age, she continued. Columbia researchers are beginning this work, starting with mice. "We're going to look for changes in gene expression (activation) in mice with older parents." ...Sleep in early life may play crucial role in brain development
...t sleep amounts are very high and undergo dramatic modifications during developmental periods of heightened synaptogenesis and synaptic plasticity. But while these findings together provide strong, suggestive evidence that synaptic circuits are modified during sleep the current study provides the first direct evid...Beyond global warming: Where on Earth are we going?!
...tive actions, including the changes, which lead to modifications of the earth's physical and biological systems and affect human quality of life and sustainable development in different parts of the world. IHDP'S goal is to produce new knowledge and priorities for improved policy and action at all levels of decisi......abolic engineering is moving away from single gene modifications and towards alteration of several targets within a particular pathway."My own suspicion is that it won't always be this simple," says Apt.On the heels of their success with P. tricornutum , however, the research team is already developing other comm...Scientists find genetic basis of insect's resistance to engineered crops
...monitoring erodes the opportunity to make informed modifications to the high-dose/refuge strategy, that could sustain use of Bt-transgenics and prolong the environmental benefits they bring by reducing the use of conventional insecticides."...Wistar study offers new support for a 'histone code' theory of gene regulation
...ion. The theory holds that coordinated patterns of modifications to DNA-packaging proteins called histones may be a...findings represent one of the first times that two modifications of a histone, one dependent on the other, have been shown to be necessary for a gene's activation. A...Does chromosome 4 hold the secret to human longevity?
...on of chromosome 4 is a gene or genes whose subtle modifications can give a person a better chance of living well beyond the average life expectancy. The researchers believe that additional genetic analyses of nonagenarians and centenarians will lead to the identification of a few genes that confer longevity in hu...Highly specific biological agents attack mechanisms of treatment resistance
...ular level, it should be possible to make rational modifications to design and produce even more potent and specific drugs for treatment of leukemia and other types of cancer, said Dr. Clarkson, head of the Hematopoietic Cell Kinetics Laboratory at MSKCC and senior author of the study. Although CML has only a sin...Discovery of dynamic sub-cellular processes could lead to medical applications
...olgi apparatus, with enzymes in each layer causing modifications as the proteins proceed through the layers, finally to be shuttled into vesicles that take them to the cell's surface. Vesicles are bubble-like containers that bud from the Golgi apparatus and transport proteins to the cell's surface membrane. The ve......the illusive mechanism whereby the addition of DNA modifications is regulated during development. Control over the addition of methyl groups is an actively pursued research topic because aberrations in DNA methylation been implicated in the process of aging and the development of various diseases, including cancer...New public-domain database could advance human computer interaction through sound
...cause people have individual sizes and shapes, the modifications must be individually tailored, much as eyeglasses must be individually fit. Lacking data, engineers previously have had to base their designs on an "average" set of values, with results for the listeners similar to using poorly fit eyeglasses. The ...Fish may show how nature diversifies
...egion may help explain how the fish achieve useful modifications of these functionally related skeletal structures. The overall results point to many different chromosome regions that affect specific aspects of skeletal anatomy in sticklebacks and reveal a flexible genetic system for independent modification o...Required activation 'cascade' identified for p53 tumor-suppressor protein
...ified a carefully orchestrated series of molecular modifications to p53 that must occur for it to perform its normal function, which is to initiate the transcription of genes involved in growth control. The findings give a clearer picture of the system in which p53 is a central player and may suggest new ways to c...Protein discovery tied to DNA master switch
...) on the tail of the histone H3. As it turns out, modifications of amino acids by methylation mainly occur on lysine. "We've known for three decades that histone can be methylated, but nobody knew the identity of the enzymes responsible for this modification until a year ago when the first lysine 9-specific histo...... protein by making a series of small, but specific modifications to the gene. One of these mutations (mut 9) produced a protein that produced an allergic response at least tenfold reduced in all patients compared to the wildtype protein. Other forms produced varied results. Some caused a 100 fold reduction in al......rtemia, or brine shrimp, the scientists showed how modifications in the Hox gene Ubx-which suppresses 100 percent of the limb development in the thoracic region of fruit flies, but only 15 percent in Artemia-would have allowed the crustacean-like ancestors of Artemia, with limbs on every segment, to lose their hin...