Study provides new insights into emerging theory of gene regulation
...derstood the precise mechanism of how two specific modifications to the DNA packaging proteins interact synergistic... and others, suggests that complex, interdependent modifications to the histones are responsible for controlling gene activity. The new data from the Wistar research...Americans' knowledge of genetically modified foods remains low and opinions on safety still split
... Americans are far more comfortable with genetic modifications to plants than animals, and are particularly supportive of genetic modifications that improve health. The majority of people polled (58%) oppose scientific research into genetic mo...Social insects point to non-genetic origins of societies
... systems is often assumed to be driven by species modifications arrived at through natural selection. Social characteristics such as caste systems and complex behaviors have been thought to be traits programmed by genes, created through evolutionary processes. Though insect social systems are in many ways as com...Project to make smallpox inoculations safe by 'leashing' current vaccine virus
...idely tolerated antibiotic or anti-viral drug. The modifications will not change the virus's effectiveness in immunizing against smallpox, but will give doctors a sure and effective way to treat it in rare cases where it causes serious illness. "The current vaccine works, we know that, but some people come down wi...Mutant gene linked to obsessive compulsive disorder
...tics, the concept of two or maybe more within-gene modifications being important in each affected individual. This is also probably the first report of a modification in a transporter gene resulting in a gain rather than a decrease in function," said NIMH Director Thomas Insel, M.D. SERT allows neurons, platelets...Study suggests new view of gene activation as a dynamic process
...he gene-activation process through these molecular modifications to be more dynamic than had been appreciated previ...oval of ubiquitin is also necessary. A sequence of modifications is therefore involved including some that may be reversible, it is now clear. The picture of certai...Mouse embryonic germ cells and male gametes created in the lab
...c state." A better understanding of how these gene modifications are programmed may come from studying the parent-specific imprints, and may have implications for therapeutic cloning, Daley adds. In therapeutic cloning, scientists take a cell from an adult animal, such as a skin or blood cell, remove its nucleus,...New insight into control of parental gene expression in eggs
... cell. The function of that machinery, which makes modifications to the genome, remains among the major mysteries i...attachment of methyl groups to the DNA -- chemical modifications that the cell's epigenetic machinery uses to silence genes.Bartolomei and her colleagues focused on ...New device can help defend against novel biological agents
...s. One of the biggest problems they had with these modifications was due to the fact that one of the devices was designed to be controlled by a Windows computer and the other by a Macintosh. "In the beginning, there was a tremendous amount of cross talk between the two computers that we had to eliminate," Eklund s...OHSU-led research examines role of copper, iron in diseases
...ncludes a mass spectrometer to study metal-induced modifications of proteins; an atomic absorption spectrometer to measure metal concentrations in cell and tissue samples; and a confocal microscope to look at protein "trafficking" within the cell and at distribution of genes involved in metal metabolism in various...Scientists at Scripps Research describe new strategy for the synthesis of glycoproteins
...en atoms within the protein's amino acids. The modifications on glycoproteins are very much a part of the language of life, and some even call carbohydrates the third alphabet, behind DNA and proteins. Sugars on proteins are like the accents on spoken words-they change the meaning without changing the spelling...The American Society for Biochemistry and Molecular Biology meets in Boston
...pids; molecular recognition and catalysis; protein modifications and turnover; protein structure, catalysis, and dynamics; regulation of gene expression and chromosome transactions; signaling pathways in disease; and the future of education and professional development in the molecular life sciences. Exhibit...New study may explain how fats damage neurons in Alzheimer's patients
...ns," Mattson said. "Our work suggests that dietary modifications and drugs that inhibit the accumulation of ceramide and cholesterol may prove effective in suppressing the processes that lead to the disease."...JCI table of contents, 16 February 2004
...ylcysteine is methylated by the enzyme Icmt. These modifications allow the protein to bind to plasma membranes. A report in the February 16 issue of the Journal of Clinical Investigation by Martin Bergo and colleagues from the Gladstone Institute of Cardiovascular Disease in San Francisco, describes that in mice...Purdue scientists: Genetically modified fish could damage ecology
WEST LAFAYETTE, Ind. - The genetic modifications that improve animals for human consumption also could doom populations if released into the wild, according to a Purdue University research team. Biologist Rick Howard and his colleagues have discovered a paradox that crops up when new genes are deli...JCI table of contents, 15 March 2004
... antizyme, which controls ODC by posttranslational modifications and suppresses ODC activity. These mice were less susceptible to UVB-induced photocarcinogenesis and had fewer visible BCCs and reduced tumor volume. In addition, administration of a suicidal ODC inhibitor to Ptc1+/ mice diminished BCC-like lesions b......ad only modest results to date, we are making some modifications to our existing antibodies to improve the molecule's ability to block FAP's action. Much more research lies ahead."...Purdue scientists: To stop cancer, keep your Icmt away from your Ras
...omplex final form, it undergoes a lengthy chain of modifications that must play out correctly if the protein is ultimately to function properly. Ras has long been known to be associated with cancer, as it is the incorrectly modified, or mutated, Ras that is behind the uncontrolled cell growth within many cance...JCI table of contents, 2 April 2004
...onfers the necessary specificity and also includes modifications to enhance expression in hypoxic and cytokine-rich microenvironments, such as those found in tumor angiogenic vessels. The transgene produces a receptor that, upon activation by TNF-_, initiates the Fas-induced apoptotic pathway. Treatment of two tum...... some 720 yards. These changes are due to modifications of the river by the Army Corps of Engineers, say Robert Criss, Ph.D., professor of earth and planetary sciences in Arts & Sciences at Washington University in St. Louis, and Washington University undergraduate student Bethany Ehlmann, an earth and pl...