Research points to potential obesity treatment
...e 1986, have patented mice with a range of genetic modifications to the POMC gene (U.S. Patent # 6,603,058), and a method of reducing insulin resistance (U.S. Patent #6,689,938) that could lead to potential treatments for diabetes accompanying obesity....Innovative efforts target epigenetics, molecular imaging
...NA molecule, leading to a variety of effects. Such modifications can change the way in which genes in the neighborhood of the mark interact with the transcriptional machinery that turns genes on or off, thereby spurring or preventing the production of the proteins that those genes encode. Also, for certain genes, ...Basic RNA enzyme research promises single-molecule biosensors
...emical reactions. They were surprised to find that modifications they made anywhere on the molecule---even far from the site where the chemical reaction occurs---affected the rate of catalysis. That's much like what is known to happen in protein enzymes, but until now there was no evidence that ribozymes behaved s...USC researcher named General Motors Cancer Research Scholar
...witches of genes that are associated with chemical modifications to the DNA and proteins in the nucleus that will ultimately make a difference in the understanding and treatment of cancer. A native of Phoenix, Ariz., Rice earned his doctorate in pharmacology and toxicology from the University of Arizona, Tucson. ...In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds
...hey have returned to their original weight despite modifications in exercise and eating habits. Now a new animal study reveals that when loss occurs, metabolic adaptations occur that mandate a return of the undesired pounds. Background These findings address a key question of whether regaining loss weight due...New space-borne instrument to track greenhouse gases, ozone destroyers, and other pollutants
... climate is modifying the atmosphere and how those modifications could in turn feed back into our climate and weather near the ground. How much ozone is sinking from the stratosphere into the upper troposphere? The answer will help scientists separate natural ozone pollution from human-made sources and give new i...Warren Pharmaceuticals publishes results of preclinical evaluation
...ythropoietin (EPO) can be achieved by a variety of modifications to the molecule. The article, entitled "Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic" was published in today's issue of the journal Science. EPO is a naturally-occurring protein that increases red blood cell produ...Comparing primate genomes offers insight into human evolution
...mp, bonobo, and gorilla. This region has undergone modifications in each of the other descendent primate species, suggesting an evolutionary role. In humans, gene mutations in this region are also associated with the inherited disorder spinal muscular atrophy. This fact, along with the observation that there are h...FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
... high cholesterol despite diet and other lifestyle modifications may require powerful LDL cholesterol-lowering agents and to do this we frequently look to highly efficacious medicines to provide the reduction they need," said Christie Ballantyne, M.D., director of the Center for Cardiovascular Disease Prevention, ......ent direction?'" said McNitt-Gray. "How will these modifications of someone's technique improve the consistency of the athlete's performance under the stress of Olympic competition?" U.S. Diving Team The researchers' unique modeling has been instrumental in a number of sports training programs, most notably th...Method to visualize gene activity may provide insight into normal development & genome function
...ique in Drosophila embryos, it will likely require modifications to work in other organisms. A detailed guide to the labeling process accompanying the paper, and available through Science's website, should facilitate the necessary adaptations. ...Evidence for the impact of climate change on deep-sea biodiversity
...Climate changes are expected to induce significant modifications in biodiversity on the global scale, yet little is known on the impact of recent climate changes on the deep-sea biodiversity. In the forthcoming issue of Ecology Letters, Danovaro, Dell'Anno and Pusceddu demonstrate that an extensive climate anomal...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...lein gene, but their alpha-synuclein proteins bear modifications not seen in healthy people that may cause the protein to act as the mutant does," said Dr. Sulzer....Select research highlights from current AACR journals
...ingh et al. identified multiple post-translational modifications that modulate dystroglycan function in these aberrant cells. Novel defects in carcinoma cells arising in this important cell adhesion molecule are similar to defects recently identified in muscular dystrophies. The research was conducted at the Lawre...K-State's National Agricultural Biosecurity Center receives $1.3 Million from Department of Defense
... an agrosecurity lessons learned database based on modifications of existing software; Cell Exchange will create a "dashboard technology" based on its "Protect America" real time content aggregation system; the University of Alabama-Birmingham will create a series of rotating images to increase awareness of agricu...New dye directly reveals activated proteins in living cells
... methods, the new approach does not require making modifications to the protein in question. "Many proteins occur in small amounts, so if you put in exogenous material you change everything," Hahn said. Among the reasons Hahn and co-authors at Scripps Research Institute in La Jolla, Calif., decided to study the Rh...Students build submarine to track Octopuses
...omputer parts will be the latest in a long list of modifications and redesigns that began with Shadow I in 1998. Shadow has become an annual senior design project in UA's Mechanical Engineering Department, and is entirely designed and built by undergraduates, with the exception of some computer programming done b...Rice finds 'on-off switch' for buckyball toxicity
...toxicity up or down, because making those kinds of modifications is something that chemists do every day in university research labs and in industry," Colvin said. "Moreover, we believe the technique can prove useful in tuning the toxicity of other nanoparticles." The researchers postulate that cell death in the t...New molecular link key to cellular proteins involved in cancer progression, other diseases
... to another. Along with ubiquitination, epigenetic modifications also include histone methylation, acetylation and DNA methylation. "The PcG silencing system is one of the best-studied model of epigenetic regulation systems," said Zhang. PcG proteins function in protein complexes to repress transcription of genes...