Cell growth and death controlled by single pathway in lymphoma cancer model
...ll culture study shows that in a type of lymphoma, molecules involved in the NF-kappa B (NF-kB) signaling pathw... the NF-kB pathway, so they treated the cells with molecules they knew would block NF-kB. They then exposed the transfected cells -- those in which NF-kB was in...3-D micro-imaging technology licensed to Carl Zeiss Jena
...e photons will interact with individual biological molecules at the same time, combining their energies. The cumulative effect is the equivalent of delivering one photon with twice the energy (half the wavelength, in the case of two-photon excitation) or three times the energy (one-third the wavelength in thre...Brain disease research, particle physics meet in the middle (ware)
...batomic particles, biological interactions between molecules and protein sequences important to genome analysis. Beyond grid computing, NMI middleware also enables many types of collaborative computing in the research and education community. Shibboleth, an NMI-EDIT software suite that manages user access to...Antibiotics alter GI tract microbes and increase lung sensitivity to allergens
...s in Huffnagle's lab discovered that fungi secrete molecules called oxylipins, which can control the type and intensity of immune responses. Huffnagle says this suggests the intriguing possibility that fungal oxylipins in the GI tract prevent the development of regulatory T cells for swallowed allergens. In th...Molecular image of genotoxin reveals how bacteria damage human DNA
...s a drug-design team, which is currently designing molecules to thwart bioterrorism agents such as anthrax and ...toxin, Stebbins says. "We can screen three million molecules against a particular target in two weeks by computer," says Stebbins. "That's good for finding about...Study helps satellites measure Great Lakes' water quality
...humidity are fairly constant, but amounts of these molecules fluctuate dramatically over lakes depending on the weather and human activity. The National Oceanic and Atmospheric Administrations Cooperative Institute for Limnology and Ecosystems Research funded this study. Merry and Mupparthy have applied for fu...Are bacteria turning our own weapons against us?
...type genes are a strong line of defense they trap molecules that parasites use to attack our cells," notes Blandin. The malaria researchers wanted to learn more about the evolution of TEP, so they enlisted the help of the Gibson team, including PhD student Aidan Budd. Their findings were completely unexpecte...Study may improve survival of transplanted livers
...ansition (MPT), opens up the mitochondria to small molecules entering the organelle and interrupting generation...mulating the liver cells to produce cell-signaling molecules - cGMP, which activates protein kinase G - required for other protective agents in the body to funct...Developing tools for reliable 'gene chip' measurements
...are collected and processed; variations in how the molecules are counted, attached to substrates and labeled fo...a well-characterized set of ribonucleic acid (RNA) molecules whose identity and concentration are known. RNA is an important product of gene activity. Users will...Promising research: From employment issues to virology
...lysis" is based on the con-cept that small organic molecules could take over the task of enzymes. These organocatalysts are so attractive because, contrary to the metal catalysts previously used most often, they are not poisonous and are robust, inexpensive and relatively easy to manufacture. In this Priority ...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...f ATP-binding proteins that transport a variety of molecules across biological membranes. ATP (adenosine tripho...ain tissue and may be linked with the transport of molecules relevant to the etiology of Alzheimer's disease, including those involved in the formation of amyloi...Cells may shoot messenger to halt protein production
...ly discovered enzyme that destroys the ribbon-like molecules of messenger RNA (mRNA). Messenger RNA is a copy o...ants to learn how the enzyme identifies which mRNA molecules to join to, and to identify the signals that trigger PMR1 to destroy an mRNA....Gene expression profiling may predict head, neck cancer recurrence
... of genetic information, into messenger RNA (mRNA) molecules that are then translated into the proteins that perform most of the cells' critical functions. Scientists then study the kinds and amounts of mRNA produced by a cell to learn which genes are expressed, which in turn provides insights into how the cel...HIV takes cellular opportunities to aid infection
...emoves its coating," said Young. "We now know that molecules exist in cells that help the virus convert its RNA genome to DNA but we don't yet know what those molecules are. Once we identify them, which this system allows, we may be able to manipulate them to halt vira...Pancreatic cancer blood test & gene studies show promise
...And eventually, she says, a better picture of what molecules and pathways are important to the initiation and growth of pancreatic cancer may yield new opportunities for treatments tailored to particular types of pancreatic tumors. Meanwhile, research led by U-M gastroenterologist Michelle Anderson, presented...Stem cells more vulnerable to toxic chemotherapy when protective molecule is disabled
...ich is capable of binding to these oxygen-carrying molecules and transporting them out through the cell membran...eat leukemia. Researchers elsewhere are developing molecules to block BCRP in leukemic cells in order to make them more vulnerable to chemotherapy. However, drug...BioCDS could hit No. 1 on doctors' charts
...heap and fast method of detecting these biological molecules would be a welcome addition to any doctor's office...sence or absence," he said. "Because many detector molecules can theoretically be deposited on the surface of each pit, the CDs should measure concentrations wit...Protein may reduce susceptibility to autoimmune disease
... type 1 diabetes can yield new insights even about molecules that have already been the subject of extensive study, such as CTLA-4," explains Dr. Wicker. According to Dr. Kuchroo, "This taught us that in many cases the disease may not be due to big changes in the affected genes but instead due to subtle diffe...New insights on sirtuins, involved in gene expression and aging
...cules, Marmorstein's research team is identifying molecules with structures that might bind to this pocket and serve as Sir2 activators. With senior author Marmorstein, the equally contributing lead authors were Kehao Zhao, Ph.D., and Robyn Harshaw, and the other co-author was Xiaomei Chai. Funding for the ...NPS Pharma and VIMAC Ventures locate at MaRS, a major new research and enterprise center in Toronto
...overs, develops and intends to commercialize small molecules and recombinant proteins as drugs, primarily for the treatment of metabolic, bone and mineral, and central nervous system disorders. The company has drug candidates in various stages of clinical development backed by a strong discovery research effor...