New dye directly reveals activated proteins in living cells
... a member of the Rho family of proteins, regulates multiple and sometimes opposite functions within the cell: movement, proliferation, cell death and shape. Injected into connective tissue cells, the dye "I-SO" displayed a bright green-colored fluorescence as Cdc42 activation and interaction with other protei...Two Virginia Tech energy-related inventions win R&D 100 awards
...g the potential for remote monitoring of data from multiple well sites throughout the world from a central location. "This could pave the way for smart oil fields, with sensor highways connected seamlessly for password- or encryption-protected monitoring from any Internet access site," says Pickrell. "This ca...Reducing allergens in the home helps inner-city children with asthma
...e, primarily because of exposure to high levels of multiple indoor allergens and tobacco smoke. "These study results are exciting because they show that changes made in the home environment can produce a reduction in symptoms comparable to that achieved with asthma inhalers," said Dr. Kenneth Olden, dir...New research suggests link between maternal diet and childhood leukemia risk
... in utero. Leukemia is a very complex disease with multiple risk factors. What these findings show is that the nutritional environment in utero could be one of those factors." ...New genetic hypothesis for the cause of autism
...s related to autism, and many experts believe that multiple genes are involved. Researchers, led by Yong-hui Jiang of Baylor College of Medicine in Houston, propose that most cases of autism can be explained by a complex model for genetic malfunction that may or may not include an altered DNA sequence. Where...Screen siblings, parents of infants with severe heart abnormalities
...elmont. "What this tells us, is that multiple other relatives including parents and siblings are at risk for progressive heart disease and that they should be screened by a cardiologist," said Towbin, also chief of cardiology at Texas Children's Hospital. At present, specialists do not recommen...Long-term effects of carbon monoxide poisoning are an autoimmune reaction
...hese changes in MBP have also been demonstrated in multiple sclerosis, which is why we paralleled the study along those lines," says Thom. To link acute CO poisoning to long-term brain injury, the team conducted tests on normal versus CO-poisoned rats, comparing their abilities to navigate and memorize a maz...Genuine stem cells found in skin might treat hair loss, wounds
...ed in the laboratory and retain a capacity to make multiple cell types when grafted." The team's analysis of the versatile skin cells also offers new insights into the underlying genetic signature common to all stem cells, said the researchers. Stem cells are undifferentiated cells whose daughters give rise t...Rare deficit maps thinking circuitry
...re thought to involve complex interactions between multiple genes and environmental triggers, the genetic basis of Williams Syndrome is remarkably well understood. People with the disorder lack about 21 genes in a particular part of chromosome 7. "Williams Syndrome yields a unique opportunity to study how ge...Select research highlights from current AACR journals
...hanges in carcinoma cells. Singh et al. identified multiple post-translational modifications that modulate dystroglycan function in these aberrant cells. Novel defects in carcinoma cells arising in this important cell adhesion molecule are similar to defects recently identified in muscular dystrophies. The re...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
...he way in which the Dr Adhesins help bugs to cause multiple diseases because they use a very common receptor on the host cell membrane as an anchor point to attack. They target a receptor responsible for regulating one of the important human immune responses, known as Decay Acceleration Factor, or DAF. "Cell ...APS awards more than $140,000 to minority students of physiology
...ses give these enzymes the flexibility to regulate multiple cellular processes. This research will help in understanding one mechanism by which cells formulate responses to external signals such as hormones or therapeutic agents. Stefanie Raymond-Whish Northern Arizona University Ms. Raymond-Whish inves...Researchers improve detection of diverse anthrax strains
...s not possible without whole genome sequences from multiple strains," said the paper's senior author Dr. Paul ...ping system has been developed from an analysis of multiple sequenced genomes of the same species," said Dr. Jacques Ravel, who led the sequencing effort at TIG...Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
... west and Cameroon to the north. Scientists say multiple courses of action should be taken immediately: Field researchers already in the region, from groups including Ecofac, Wildlife Conservation Society and the University of Rennes, need greater human and financial resources to enhance monitoring in t...University of Pittsburgh receives $10 million grant for head and neck cancer
...ssor of pharmacology, and Dr. Grandis will examine multiple signaling pathways implicated in the proliferation...y is to develop therapeutic approaches that target multiple signaling pathways." Drs. Siegfried and Grandis are examining the interaction of two types of protei...OHSU-VAMC study sheds light on estrogen's benefit for MS
...ars, doctors have suggested the best treatment for multiple sclerosis is pregnancy. Now, an Oregon study is delivering solid evidence to support the theory. Researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center have uncovered the mechanism by which estrogen, produc...Computer database being developed at Temple will allow for better inventory of chemicals
... be converted to a Web-based application to enable multiple users and at the same time, provide a high level of security....Trojan Horses, xenon imaging and remote controlled genes
...atly extend the capabilities of MRI for monitoring multiple cancer markers simultaneously using the noble gas xenon as an imaging agent. By encapsulating a single atom of xenon within a cage made of cryptophane, it can become a sensitive reporter of changes outside the cage. When the cage is "rattled" by a...OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
...ne pathogen, such as rotavirus, although there are multiple causative pathogens. Efforts are also underway to prevent exposure to the pathogens responsible for diarrhea in developing countries. However, these require massive improvements in sanitation, hygiene, and nutritional status in developing countries,...... of 16 types of protein molecules, most present in multiple copies. Before infection, these proteins fit together to form a hexagonal shape. Together with the 12 legs that extend from the T4's tail to grasp the victim E. coli, the virus resembles an Apollo moon lander. When the T4 approaches "touchdown" on an...