Tag: "muscular" at biology news

'Obesity sleuths' find chronic diseases linked to behavior contrary our DNA

...t of this disorder. The benefits are flexibility, muscular conditioning, and cardiovascular and general health. Rheumatoid Arthritis: Exercise for patients with this disorder minimizes loss in muscle strength but not in bone loss. Conclusions This effort clearly points out that a sedentary lifestyle le...

Vogel's new book is meaty

...ls to pull them, and the malevolent mosquito is a muscular marvel, able to beat its wings 300 to 400 times per second, generating its telltale buzz. Vogel's book has so delighted its reviewers and readers that Science magazine was moved to comment in its review "Few among us can explain the often slightly ...

New gene therapy tool successfully treats mice with hemophilia A

...eases such as cystic fibrosis, sickle cell anemia, muscular dystrophy and some forms of cancer."...

Protein causes muscle wasting syndrome in mice

...al new treatments for muscle-wasting diseases like muscular dystrophy, the team from Johns Hopkins and pharmaceutical company Wyeth report in the May 24 issue of Science. "We now know that myostatin can affect muscle growth and maintenance in adult animals and that it acts throughout the body," says Se-Jin L...

Unique population of muscle stem cells found in mice

...genetic muscle-wasting disease similar to Duchenne muscular dystrophy, Johnny Huard, Ph.D., and his colleagues...e muscles of mdx mice, a rodent model for Duchenne muscular dystrophy. In humans, this disease causes muscle weakness and early death because of respiratory or ...

Can we enlist substitute genes to fight muscular dystrophy

...ne, dystrophin, which is responsible for Duchennes muscular dystrophy (DMD), a fatal neuromuscular disease. In...ng from DMD. Utrophin has been a major focus in muscular dystrophy. Dystrophin and utrophin perform similar tasks at the neuromuscular junction where nerve ...

Damaged DNA synthesis enzyme shown to cause progressive muscle weakening

... deficit, the first symptoms of which is often the muscular degeneration known as progressive external ophthalmoplegia. Recently, this disease was linked to a mutation (called Y955C) in one of the cell's genes that produces the enzyme (DNA polymerase gamma) that is responsible for replicating mitochondrial ...

Scientists identify DNA flanking region as trigger for genetic instability

...n nature and include myotonic dystrophy (a form of muscular dystrophy), Huntington disease, and Fragile X syndrome (the most common form of inherited mental retardation). In these disorders, a disease state is caused when too many of the triplet DNA sequences within the gene are repeated. This mutation affect...

Researchers discover new mechanism that targets and destroys abnormal RNA

... of human disorders, including cystic fibrosis and muscular dystrophy. In the second Science paper, lead author Ambro van Hoof, in Parkers laboratory, did experiments that revealed the specific cellular machinery that produces nonstop decay. According to Parker, those experiments showed that a multi-enzyme ...

Failure of critical protein connection at heart of cardiomyopathy

... known for its relationship to Duchenne and Becker muscular dystrophy, diseases in which the muscles weaken, the child requires a wheelchair and dilated cardiomyopathy occurs. A mutation in the dystrophin gene causes these diseases. However, in the case of dilated cardiomyopathy alone, the end portion of the...

Putting microRNAs in their place

...ons protein, which, when mutated results in spinal muscular atrophy, the second most common childhood neuromuscular disorder. This finding of shared components between the SMN complex and the miRNP suggests a possible link between the pathway of miRNA activity and the progression of this common disease....

Scientists meet to discuss latest in how sex matters

...ential. Mutations on the X chromosome may lead to muscular dystrophy and in rare cases, can cause the embryo to be miscarried. As early as the first trimester, the embryo is subjected to significant factors that can contribute to sex differences and create long lasting changes in the developing fetus. The em...

Researchers discover gene causing deadly infantile form of genetic kidney disease

...combined number of those who have cystic fibrosis, muscular dystrophy, Downs syndrome, hemophilia, sickle cell anemia and Huntingtons disease. The disease affects people equally irrespective of age, race, gender, ethnicity, geographic location or socioeconomic status. ARPKD, often referred to as infantile PK...

Tether for water channels found: May impact research on brain swelling

...ells to the external scaffolding that provides the muscular architecture. "The standard answer to why muscles deteriorate in these diseases is that the muscular architecture is weakened," says Neely. "We've shown that the same protein complex involved in muscul...

Cells on the verge of suicide

...ell death is associated with neurodegenerative and muscular diseases such as Alzheimer's, Parkinson's, Hunting...ng cells in the treatment of neurodegenerative and muscular diseases. In the article, Steller and colleagues outline the entire molecular pathway by which a pop...

Immunotherapy treatment shows dramatic results for rare neurological disorder

...se, touch, and emotional distress that can set off muscular spasms. People with SPS are often too disabled to ... Since GABA modulates the action of the excitatory muscular neurotransmitters, lower levels of circulating GABA allow the excitatory neurotransmitters to hijack...

Researchers identify potential for prenatal gene therapy

...ells in attempts to correct neurological, hepatic, muscular and possibly other types of congenital disorders pre-natally. Details of Tolar's presentation: Time: Monday, December 10, 2001, 8:15 a.m. EST Session name: Experimental Transplantation Title: The in utero transfer of murine multipotent adu...

U of Minnesota researchers identify gene for myotonic muscular dystrophy Type 2

.... Myotonic dystrophy (DM), the most common form of muscular dystrophy in adults, affects the eyes, heart, hormonal systems and blood, in addition to causing muscular dystrophy and involuntary muscle stiffness (myotonia). Although the genetic change underlying one f...

New 'mighty mice' research brings muscle growth closer to reality

...unities to treat many muscle-wasting diseases like muscular dystrophy or cachexia, the muscle loss that accompanies some cancers and AIDS. Blocking myostatin in animals could also create livestock with more meat and relatively less fat. "The agricultural applications are probably more straightforward, since ...

Sorting the girls from the boys

...d by life-threatening single gene diseases such as muscular dystrophy or haemophilia. Team member Dr Harvey Stern, giving the latest results from an ongoing clinical trial to the European Society of Human Reproduction and Embryology annual meeting in Lausanne today, (Wednesday 4 July) said that the technique,...

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