Tag: "mutant" at biology news

New Cancer Switch Discovered By Duke Medical Center Pharmacologists

...ncer patients. The scientists discovered that some mutant BCR-ABL genes eliminated both the cancer-causing a...capabilities of the cells. However, they found one mutant that did activate the oncogene ras and did block apoptosis, but did not cause the cells to become ca...

Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"

...isease, as well as discovering a new conceptof how mutant genes may produce disease. The scientists discove...me expanded CAGrepeat. "Traditional dogma is that mutant genes produce proteins that eitherdon't work at all or don't work well," said Burke, the first autho...

Photosystem I -- An Intermediate Step -- May Not Be Necessary For Plants

...he Oak Ridge researchers explained they found that mutant algal cells were able to grow and survive in near-normal conditions. "No pun intended, but this sheds new light on photosynthesis," Greenbaum said. "This is speculation, but this could be a crude prototype of primordial photosynthesis." Wanting to ...

Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases

...est how RTP works, the researchers had to create a mutant versionof the protein that would not interact with...ing proteins from a human system andthen finding a mutant protein will lead to understanding of the diseaseprocess involving helicase proteins," Bastia said. ...

Two Long-sought Diabetes Gene Found

...ubjects from these families had also inherited the mutant gene. They are expected to develop diabetes in the future. Finding MODY3 led to the rapid discovery of MODY1, a functionally related gene known as HNF-4-alpha, which had been mapped to the MODY1-region of chromosome 20 by Markus Stoffel, M.D., Rockef...

ORNL Finds Common Genetic Cause For Epilepsy, Migraine

... effects of the chromosome 8 Cacnl1a4 gene foundin mutant "tottering" mice, which have been studied extensively as modelsfor human epilepsy. The specific region of the mouse gene has a counterpartin humans (a chromosome 19 region) that had previously been identified ascausing episodic ataxia (spells of inco...

Plants Need Vitamin C, Too

...esearchers at the Boyce Thompson Institute created mutant plants that have no capacity to make vitamin C, and they then subjected the plants to strenuous environmental factors such as high levels of ozone and ultraviolet light. "We grew our Arabidopsis thaliana plants in elevated levels of ozone. For a n...

Purdue Researchers Prod Plants To Clean Up Pollution

...rough and his Australian collaborators described a mutant strain of Arabidopsis thaliana (a plant in the m...ons off a section and holds the toxins at bay. The mutant plants lacked the peptides that tie up and detoxify the heavy metal. In subsequent related research,...

Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules

.... Using genetic engineeringmethods, they created a mutant protein with a specialized chemical hookthat allows the reporter group to be attached precisely in the right place.They produced the protein and tested it with maltose, and it worked. "Itwas a very exciting moment to see that our computer models actu...

Duke researchers find existing drugs can stop fungus that attacks AIDS patients

... for calcineurin in the fungus. They foundthat the mutant fungus lacking calcineurin could no longer survive at bodytemperature, and as a consequence, could no longer infect animals. Theyalso found calcineurin is required for fungal growth at two other conditionsfound in animals and people: a high pH and hi...

Resistance To Leptin Contributes To Obesity

...ellow Agouti (Ay), is obese due tosingle copy of a mutant gene. In the leptin injection study, NZO and Ay mice did not respond tosubcutaneous leptin doses of 5 micrograms per hour, a 10 times greater dosethan required to achieve a maximum response in the lean mice. The DIO micelost weight when give...

Single Mechanism Seen To Underlie Group Of Neurodegenerative Diseases: Mutant Proteins Form Insoluble Masses In The Nuclei Of Neurons

...CAG -- is oftenrepeated 15 to 20 times, but in the mutant proteins the repeats increase innumber to 50 or ev...ear space.And once this aggregation has begun, the mutant proteins appear to recruitnormal versions of the protein into the growing mass, called an inclusion,...

Mutant Gene Not Sole Explanation For Hiv Non-Progression

...copies of the gene. People with two mutant copies of the CCR5 gene appear -- i...ave shown that individuals with one mutant copy of the CCR5 gene are disproportionately represented among long-te...

At-Risk Women Want Breast Cancer Gene Test--If 'Pros' Outweigh 'Cons'

... As scientists identify an increasing number of mutant genes associatedwith diseases, public debate has focused on fears that employers and insurersmight use the results of such tests to discriminate against those who carry themutant genes. Despite this, most women in the study perceived relatively fewd...

New Gene For Mental Illness

...y be carrying the gene. Individuals who have two mutant WS genes have the distinctive Wolfram syndrome,characterized by diabetes mellitus and optic nerve deterioration. Wolframsyndrome patients often exhibit depression, violent and assaultive behavior,chronic anxiety and/or panic attacks, and hallucinatio...

Fruit Flies May Shed Light On Cocaine Addiction

...hey are using is to selectfrom vast collections of mutant flies those that respond differently to cocaine. By comparing the genes of these flies with those of normal flies, they hope toreveal the genetic and biochemical pathways involved in cocaine-induced behaviorand addiction. These insights may lead to...

Transgenic Mice Created By Researchers May Shed Light On Human Heart Disease

...ntract, shesaid. But in heart muscle carrying the mutant form of the myosin gene, thenormal, parallel align...iny muscle fibrils located in the heart. Although mutant troponin T genescause little or no heart enlargement, the production of even small amountsof the pro...

A Mutation In The CCR5 Coreceptor Slows HIV Disease Progression In Children Born To Seropositive Mothers

...For further information : "CCR5 chemokine receptor mutant allele in HIV-1 mother-to-child transmission anddisease progression in children" M. Misrahi 1 , J.P. Teglas 2 , N. N'Go 3 , M. Burgard 3 , M.J. Mayaux 2 , C. Rouzioux 3 , J.F. Delfraissy 4 , S. Blanche 5 JAMA, vol 279, 4, pp 277-280, 28th January ...

Scientists Identify Protein Essential For Iron Absorption, Boost Understanding Of Iron-Deficiency Anemia

...endently found the sameprotein, but did not have a mutant animal that could help identify its role. "This protein doesn't answer all the questions in iron transport," hesaid. "What's remarkable is that it shows up in so many ways."...

Biologists Map First Gene For Age-Related Hearing Loss In Mice

...e only genes cloned so far are from the "shaker-1" mutant andSnell's "waltzer." These mice not only lose their hearing, theyhave a balance disorder which causes them to run in wild circles.Both the shaker and waltzer genes produce an abnormal form of theprotein myosin, which causes degeneration of the hair ...

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