Tag: "mutant" at biology news

A worm is more like a human than previously thought

...hman explained that his lab identifies and studies mutant worms that are defective in early development. They then identify the genes causing those birth defects. "Our goal is to learn about how those genes work and what can go wrong when they are broken. In this way we can hope to learn how to fix them,"...

Mice nibbling at the secrets of NF1

... lacks the NF1 gene have been unsuccessful because mutant mice die as embryos. However, using an advanced genetic engineering technique, Dr. Parada and his team were able to produce a strain of mice in which the NF1 ablation is restricted to mature neuronal cells only. This conditional NF1 knock-out thereb...

Rockefeller researchers identify defense system in plants

...ina. Because previous studies demonstrated that mutant Arabidopsis plants lacking the ABI5 protein grew w...BI5. Next, Lopez-Molina and Mongrand showed that mutant strains lacking the ABI5 protein, when grown in the presence of ABA, had lower survival rates than t...

Scientists find just how discriminating a worm can be: Unique system of overlapping odor sensors discovered

...n and Wes used standard techniques to search among mutant worms for those that were unable to detect the dif...he paired AWC cells with a laser beam. Either the mutant worms or the operated worms could sense both odors perfectly well, but with a change in one of the A...

Researchers find evidence of aging system that may promote long life

... The mechanism begins in the brain with a mutant gene that suppresses the release of hormones that ... The researchers bred fruit flies with mutant InR. They believed the mutation suppressed the release of juvenile hormone, arresting th...

Virus studies reunite two families of major insect-borne viruses

... Along the way, they realized they could use the mutant viruses to map the glycosylation sites, providing a rare opportunity to analyze the structures of the two major proteins involved, called E1 and E2. The researchers developed the map by creating a virus with a mutation in only one of the glycosyla...

Hopkins' Young Investigators' Day winners shine in the spotlight

...udies clarifying what goes awry after inheriting a mutant gene for inherited polycystic kidney disease. She's developed a model, using the gene's resulting mutant protein, that captures key features of the disease. She's also mapped many of the biochemical steps...

Merlin tells when to grow and when to stop

...ork delineates the pathway by which cells that are mutant in merlin become tumorigenic. Cell density is one of several growth-limiting parameters. Normal cells proliferate until they occupy the space allotted to them, and stop proliferating once they contact other cells or a dense extracellular environment....

A dose of prions might slow the progress of prion diseases.

...inion, not delay onset." However, there might be a mutant form of hamster PrP that could bind to the abnormal mouse form but not turn into the abnormal form itself, he says. Others aren't convinced. "It seems very unlikely that injecting normal cellular prion protein will prevent the development of dise...

Potential new anthrax therapy discovered

...ccine, the use that gave the subunit its name. The mutant protective-antigen molecules can elicit an immune ...duced by normal protective antigen. In the future, mutant protective antigen may fill the bill as both an anthrax vaccine and treatment, negating the need for...

UCSD biologists discover new class of genes responsible for embryonic development

...ly dies." In addition, the cells containing these mutant genes are vulnerable to bursting and shriveling. This is due to the inability of the defective embryo's cell membranes to maintain the cell's osmotic pressure, which can produce an undesirable flood of fluids into or out of the cells. The UCSD scient...

Lipoprotein lipase: Location, location, location.

...n LpL that is mutated at this short sequence. The mutant protein binds poorly to heparin and loses activity...mice. Native LpL is active as a homodimer, but the mutant form readily dissociates into inactive monomers, suggesting that HSPGs help maintain the quaternary ...

Scientists switch memory recall on and off in fruit flies

...e memories." The key to the study was expressing a mutant form of a gene called Shibire ("sha-beer-ee") in t...involved in neurotransmitter release. However, the mutant form of the gene encodes a protein that works at low temperature (20C) but which blocks neurotransmi...

E. coli bacteria may be more useful than you think

...rmally, phage lambda kills bacteria, but a certain mutant lambda phage, when it infects a particular mutant strain of E. coli, injects its DNA only to have the DNA degraded. Meanwhile, the empty phage particl...

Scientists find solution to a mystery surrounding Alzheimers, Huntington's and other neurological diseases

...ed proteins. But when Bence and Kopito inserted a mutant huntingin gene, the cells turned bright green in a...tried the same experiment using genes that produce mutant forms of CFTR a protein that has been linked to the disease cystic fibrosis. The results were the s...

Food safety: French discovery explains how Listeria penetrates the body, and may suggest new drug delivery strategies

...n protein, proved fatal in most cases, whereas the mutant strain caused no deaths and failed to cross the intestine and invade organ tissues. Thus, the French investigation identifies a "virulence factor" or molecular mechanism by which Listeria causes disease, thereby addressing a key recommendation of a...

Writing in Nature, scientists identify genes key to differentiating top from bottom in plant leaves

...f gases and water with the environment." In plants mutant in KANADI, Poethig and his colleagues found that the bottoms and tops of leaves were more or less identical. While the groups research suggests that KANADI may work in conjunction with other genes, including the one described by Kathy Barton and her...

Somatostatin in sexually dimorphic gene expression

...ales. Surprisingly, the males and females in this mutant strain maintain their sexually dimorphic sizes and growth rates, suggesting that not all genes that are regulated by pulsatile GH release are equally sensitive to the continued presence of the hormone during the interpulse portion of the cycle....

UNC, Penn State scientists find gene that controls water retention in plants

...xperiments showed they were right. But because the mutant plants wilted, they thought the gene probably also controlled water retention. Since Assmann specialized in that area of biology, Jones sent seeds to her and Wang, who analyzed the resulting plants. The Pennsylvania researchers found that plants wit...

Gene that directs fate of many embryonic stem cells identified

...bed the master gene they isolated casanova because mutant animals lacking the gene have a split heart. Casan...ing them with the cas gene. They first showed that mutant zebrafish lacking the casanova gene failed to develop endoderm at all. In a second round of experime...

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