Tag: "mutant" at biology news

MIT's Mini Respirator Breathes Life Into Mutant Mice

..." used to treathuman polio patients, was built for mutant mice suffering from respiratorydistress. These ani... Preliminary tests of the machine with one kind of mutant mice arepromising. The ventilated mice survived over 50 percent longer than the absolutelife expecta...

Peptides Implicated In Body's Response To Pain

...nd neurokinin A. They observed that the colony of mutant animalsmaintained the same response to mild pain as their non-mutant mousecounterparts. The mutant mice, however, exhibited a reduced response whensubjected to stimuli producing moderate-to-intense p...

Eviction From Scum Home Makes Disease-Causing Microbe Vulnerable

...o a detergent that itnormally weathers easily, the mutant bacteria began falling offwithin 30 seconds, and t...Pearson is the one whoactually made the vulnerable mutant form, using molecular biologytechniques like restriction enzymes or "molecular scissors" tosnip the ...

Human Bone Disorder Reproduced In Mice

...ne-Albright syndrome (MAS) starting from abnormal, mutant stromal cells. Thedisorder is characterized by sca...Robey has uncovered anotherpeculiarity of MAS-that mutant and normal cells must both be present in order toform defective bone. This finding concurs with the...

Researchers Discover How Ulcer Bug Becomes Antibiotic-Resistant

...isrupting its DNA sequence. The H. pylori with the mutant rdxA gene became fully metronidazole-resistant. Th...trains become etronidazole-resistant by picking up mutant genes from already resistant strains -- many bacteria donate pieces of DNA that carry resistance gen...

Electron Accelerator Provides Unique Proof Of Gene Repair Process In Living Cells

...ated with three of the four proteins, and produced mutant yeast and mice to study the way an inability to repair genes may lead to cancer. For the experiment reported in Science, Petrini enlisted the help of UW-Madison physicists and engineers who work at the university's Synchrotron Radiation Center, wher...

Cystic Fibrosis Gene Protects Against Typhoid Fever

...stic fibrosis develops in children who inherit two mutant copies - one fromeach parent - of the gene that en...gnificantly more S. typhi than did cellsexpressing mutant CFTR. The researchers then added to the cells antibodies andsynthetic molecules designed to bind to...

Mice Lacking The Pax8 Gene Suffer From Hypothyroidism And Fail To FormThyroxin-Producing Cells Of The Thyroid Gland

...ingen, Germany report on the generation of a mouse mutant lacking the Pax8 gene. These mice suf... with no functional Pax8 protein. The mutant mice develop to term and die within the first three weeks after birth. The thyroid glan...

University Of Cincinnati Biologists Find Evidence For Unusual DNA Repair InArchaea

...ombination experiments. A common type of microbial mutant is called anauxotroph or nutritional mutant. The mutant requires a supplement in its growth medium toreplace a particular nutrient a normal cell could produ...

Raymond Receives $113,000 NIH Grant To Support Cell Cycle Regulation Research

...ymond studies single cellular organisms to isolate mutant cells which are defective in normal cell-cycle reg...ctive medium for performing these experiments with mutant cells. Her NIH grant will support work that specifically addresses, through genetic and molecular ...

Gene-Altered Mice Boost Studies of Cardiomyopathy: Enables Research Into Causes And Treatment Of Heart Failure

...te animal model of the disease. They introduced a mutant form, active only in the heart, of a gene called CREB , which controls the activity of several other genes that regulate the growth and development of cardiac muscle. The altered gene -- which blocks the normal affects of CREB -- is turned on onl...

Ionotropic Glutamate Receptors Share Tetrameric Structure With The Voltage GatedPotassium Channel

...ptors that did not desensitize. These mutant receptors were than used to understand how neurotransmitter binding leads to the opening of the channel pore. Using a pharmacological trick, the minute currents flowing through single channels could be observed...

Duke Researchers Call Gene Therapy A Promising Strategy For Sickle Cell Anemia

...y carries oxygeneffectively, but also inhibits the mutant globin protein from sickling. In their experiments, the Duke Medical Center scientists collected bloodfrom sickle cell patients and from umbilical cord blood, the afterbirth ofnormal infants. From this blood they isolated precursor red blood ...

Researchers Identify New Component Of Circadian Clock

...increase in transcriptionalactivity. BMAL1 and the mutant version of CLOCK also bound to the same sites,but no transcriptional activity resulted. "These findings tie together Clock, which has been genetically proven tobe a component of the circadian system, with the mammalian version of per, whichis...

Master Molecule Forms Brains In Frogs And Elbows In Mice

...nts. Instead of having an elbow, for instance, the mutant mice had one long, unsegmented arm. The mice's fingers and toes also had no joints and, in addition, exhibited occasional spurs in the cartilage that makes up such tissues. In addition to the likely clinical implications of the work, of particular in...

Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol

...cation. Totest their hypothesis, they treated the mutant amnesiac flies with agents thatincreased cAMP levels and were able to reverse the alcohol sensitivity.The finding made a giant leap from an isolated gene in fruit flies to an entiremolecular pathway previously observed in animal and human cell cultur...

Gene Linked To Glaucoma, Hydrocephalus, And Other Birth Defects

...3, he was the first to describe aspontaneous mouse mutant known as congenital hydrocephalus (ch). These muta...sonLaboratory in Bar Harbor, Maine, studied the ch mutant mice and described amalformation in the meninges, the spongy tissue around the brain. This defectpre...

Scientists Identify New Gene That Controls Sleep/Wake Cycle

... down the fly's clock, to about 28 hours. Thethird mutant blocks the circadian cycle altogether. The last mutant, which lacksthe protein product of the double-time gene, provided the clues to decipheringthe mechanism behind the circadian oscillations. The researchers found that, in the mutants lacking do...

UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease

... Florida neuroscientist has discoveredand cloned a mutant gene in chickens, helping researchers better understanda rare human eye disease that causes blindness at birth. Sue Semple-Rowland, an associate professor of neuroscience in UF'sCollege of Medicine and the UF Brain Institute, has established a s...

Purdue Study: RNA 'Motor' Transports DNA In Virus

...As. However, mixing of two, three and six inactive mutant pRNAs restores DNApackaging activity as long as an interlocking hexameric ring can be predicted toform by base pairing of the mutated loops in separate RNA molecules. Thestoichiometry of pRNA for the packaging of one viral DNA genome is six.Homogeneo...

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