Tag: "mutants" at biology news
Scientists unlock molecular mechanism that controls cell growth
...onship between Hsp70 and Bag1, Morimotos team used mutants
of the two proteins. Their results showed that Bag1 mutants
defective in binding to Hsp70 stimulated Raf-1 and the signalling pathway, despite the fact that the...
Simultaneous reports by scientists at the Scripps Research Institute show how they made bacteria do what nature doesn't
...ne mistake in 100,000 tries. But the proofreading mutants
are so good at making mistakes that in their paper, Schimmel and his colleagues report that 24 percent of all the valines are randomly replaced with aminobutyrates. These strange new proteins can then be purified and studied in isolation, or left in ...
Potential new anthrax therapy discovered
...bbed "protective antigen." When protective-antigen mutants
were injected together with a normally lethal mix ...e results are remarkable." The protective-antigen mutants
are good candidates for an anthrax therapy because the normal form of protective antigen in and of i...
UCSD biologists discover new class of genes responsible for embryonic development
... dividing cells. First discovered in 1988, six PAR mutants
have been identified in C. elegans and related genes have been found in frog, fruit fly and mammalian cells. Mutations in all of these genes, like mutations in the pod genes, result in symmetrical, two-celled embryos incapable of developing normally....
UNC, Penn State scientists find gene that controls water retention in plants
...sin that maintains a library of uncatalogued plant mutants
that researchers can sort through....
UCSD researchers decipher molecular "code" capable of controlling plant water loss during droughts
...long-term closures of stomata. One effect of the mutants
insensitivity to the drought-stress hormone is tha...their colleagues were able to demonstrate that the mutants
stomata could also be closed for long periods. "Scientists have speculated for years that there may...
New mutant mouse repositories established for biomedical researcher community
...racterize the genetic and phenotypic makeup of the mutants
so that models are validated and may optimally serve as models of human disease. Efficient facility systems provide genetic quality control and disease safeguards. The MMRRCs offer expertise in the biology of laboratory micecovering areas of cryobiol...
Plant response to light and stress
...tein that degrades IP3. Dr. Zhus transgenic fiery mutants
accumulate abnormally high levels of IP3 in response to ABA or stress, and thus display an enhanced expression of stress-adaption genes (along with a really bright luminescent signal see attached figure). This work represents the first direct geneti...
How brain cells remember their birth order
...te neurons, said Doe. We can also create and study mutants
in genes that affect this birth order. In their experiments, the scientists sought to understand in what order the fly neuroblasts expressed four transcription factors that were good candidates for regulating the birth order of daughter cells. Thes...
Virginia Bioinformatics Institute and Phenomenome Discoveries developing software to allow visualization of genes and proteins
...very fine level, the differences between different mutants
to find out the function of the mutated genes. The bioinformatics software developed under this collaboration will organize and display the expression level of large numbers of the small organic molecules in ways that assist scientists with its inte...
How bacteria harden their "armor"
...erase enzyme that would render polymyxin resistant mutants
sensitive again." In their experiments, the Duke biochemists studied the mechanism behind resistance to the antibiotic polymyxin, which is normally used as a topical ointment against skin infections. Thus, for example, said Raetz, adding a transfera...
Novel means for stopping transcription found, Hopkins scientists report
...mal function, the Hopkins scientists created yeast mutants
with a temperature-sensitive Nrd1 gene. In these mutants, above a certain temperature the gene produces an altered form of Nrd1 that can't bind the CTD and hence can't affect its target genes. Because the scientists believed Nrd1 limited transc...
New small gene class found by Dartmouth geneticists may exert far reaching influence on cell behavior
...gs built on work over the past decade in roundworm mutants
with striking developmental defects. In 1991, Lee and Ambros found lin-4, a surprisingly small gene that produced a particular hook-shaped RNA. This little gene seemed to be a temporal switch in development, but unlike most timing controls, instead ...
Complex carbohydrate found to regulate plant growth
...t sugar in its place. He also discovered that when mutants
received fertilizer containing L-fucose, plant gro...the boron quite as well, Darvill said. Fertilizing mutants
with high levels of boron also reversed dwarfing because the high amount of available boron effectiv...
Mutant proteins may be key to defeat chemical warfare
... techniques allowing him to make a large number of mutants
simultaneously. By further testing each mutant at ...unds, he can quickly compare the activities of the mutants
and select the fastest mutant. "Whereas it would have taken at least a week to make and characteriz...
Drowsy fruit flies illuminate first molecular pathway, in any species, known to regulate rest and wakefulness
...after such a prolonged period of wakefulness; CREB mutants
slumber even longer than normal flies in the aftermath of deprivation. CREB, which is evolutionarily conserved in species from slugs to mice to humans and already known to function in cyclic AMP signaling, is also known to play an important role in l...
Illuminating how plants adapt to light
...se patterns with those of known laboratory-induced mutants
in the plant photoreceptor molecules, called phyto...rying strains to those of known laboratory-induced mutants
in the receptor genes. The idea was that if any of these natural variants looked like a laboratory m...
Gene triggers stem cell differentiation in the intestine
...a role in absorbing nutrients. When we studied the mutants
with no Math1 , we found that all three secretory cell types were missing, said Zoghbi. This told us that Math1 was important for basic stem cell differentiation, and that Math1 -negative progenitor cells gave rise to the enterocytes, whereas M...
Method quickly surveys yeast genome by gene function, not sequence
... each lacking a different gene, and put the pooled mutants
in an environment that tested their ability to rep... Testing all 4,600-plus existing mutants
at the same time depends on a "barcode" system developed by Dan Shoemaker of Rosetta Inpharmatics, I...
UCSD biologists visualize protein gradient responsible for dividing embryo into nervous system, epidermis
...is by examining the pattern of Sog accumulation in mutants
lacking function of the Tolloid gene. We observed that in the absence of Tolloid, Sog levels are greatly elevated in epidermal cells and accumulate steadily until the entire embryo contains nearly uniform amounts of Sog. We also found another cellula...
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