Tag: "mutants" at biology news
New rat resource and research center to help investigators understand human disease
...kedly increase the use of specific rat strains and mutants
for research and thus facilitate the use of these animals to understand problems of human health and physiology." In addition to the activities described above, the RRRC will provide "value-added" services when a given rat strain is imported into the...
UCSD biologists discover that machinery for cell division plays dual role in partitioning developing embryo
...instaking experiments that Rappleye conducted with mutants
of the roundworm C. elegans. Over a two-year period, Rappleye found mutants
with impaired APC function and demonstrated that the protein complex helps the sperm push a protein ...
New mouse model enables studies of heart, brain and spinal cord
... PAX-3 is really important, then the hearts of the mutants
will be abnormal." If the embryos survive, he should be able to determine what role, if any, PAX-3 plays in generating heart muscle cells....
'Wishful thinking' gene regulates neural development
...e set out to identify genes for receptors, isolate mutants
and just go where the resulting phenotypes took us...oratory mounted a large-scale effort to create fly mutants
that exhibited abnormalities in various parts of the synaptic machinery, which they detected using m...
Dartmouth researchers expose weakness of common parasite
...rotected from a lethal challenge infection. "These mutants
may offer great potential as a strategy for vaccine development," Fox said. Touting the benefits of applying genetics to human pathogens, Bzik said, "the parasite carbamoyl phosphate synthetase II enzyme is an attractive target for the design of drug...
Pinpointing the protein problem in Lou Gehrigs Disease
...al ALS or FALS. He is attempting to understand why mutants
of the enzyme superoxide dismutase (SOD1) fail and...long as 18 years, says Coln. The existence of SOD1 mutants
associated with this milder form of FALS makes it an intriguing biophysical and biochemical marker. ...
From nanotechnology to raspberries, Virginia Tech inventions and creations can improve our lives
...de for capsule synthesis to produce non-capsulated mutants
of the desired organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae was genetically modified with a large deletion in a chromosomal region of the DNA which encodes for capsule synthesis. The attenuated strain is a sa...
How the body copes with fear
...f the journal Nature 1st August 2002 that in mouse mutants
lacking the cannabinoid receptor CB1, erasure of fear behavior evoked by an aversive acoustic sound was considerably lessened compared to normal control mice. The researchers hope that these findings will lead to new approaches for the treatments of ...
New AIDS drug discoveries to battle drug-resistant HIV strains
...more active against common HIV strains and all the mutants
tested, according to the researchers. The team developing the drugs includes scientists from Rutgers, The State University of New Jersey, and the National Institutes of Health (NIH) in the United States; and from Janssen Pharmaceutica in the United ...
Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors
...d in the mutant mice. A first assay tested if male mutants
emit 70 kilohertz ultrasounds when first exposed t... sexual advances toward males, suggesting that the mutants
are better at distinguishing between sexes without prior experience, or that their sexual drive over...
Shadow proteins in thymus - Clues to how immune system works?
...oteins found in the thymus of normal mice. And the mutants
exhibited widespread autoimmunity. In fact, their condition was reminiscent of a condition found in humans carrying a defective AIRE gene, autoimmune polyglandular syndrome. It is not yet clear how the shadow proteins educate developing T cells insi...
Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
...ications of Gaucher disease, if they are caused by mutants
that respond to chaperone therapy. The article, "Chemical chaperones increase the cellular activity of N370S beta-glucosidase: A therapeutic strategy for Gaucher disease" was authored by Anu R. Sawkar, Wei-Chieh Cheng, Ernest Beutler, Chi-Huey Wong,...
EMBO supports researchers from emerging economies
...NA tagging approach in plants to induce beneficial mutants
resistant to different stresses'. Yamilla Carpio (...h will focus on 'the characterization of zebrafish mutants
with defects in eye development at the cellular, molecular and genetic level'. She will start this w...
Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize
...govern the end of mitosis. After isolating several mutants
within a group of genes called the mitotic exit network (MEN), Shou concluded that MEN controls the end of cell division by transmitting a signal to dismantle a protein complex dubbed RENT, which keeps the cell from ending mitosis prematurely. Shou, ...
Ulcer-causing pathogen uses hydrogen for energy
...lori without hydrogenase, only 24 percent of these mutants
colonized in mice, as opposed to 100 percent of th...that was able to utilize hydrogen, Olson says. The mutants
that did colonize in mice also had lower levels of bacteria, he says. Hydrogenase is a complicated e...
Organic & Biomolecular Chemistry
...tions of cyclic nonaketides by Aspergillus terreus mutants
blocked for lovastatin biosynthesis at the lovA and lovC genes John Vederas, Alberta, Canada...
Got milk? Scientists discover key lactation gene
...copies of the XOR gene. As expected for homozygous mutants
of a housekeeping gene, homozygous XOR-mutant mice died by 6 weeks of age. In contrast, though, the heterozygous XOR-mutant mice appeared normal, healthy and fertile, but first author Claudia Vorbach and colleagues soon noticed that pups from the XOR...
JCI Table of Contents, January 2, 2003
...e lackingAMPKa2. As they report (pages 91-98), the mutants
are normal with respect tobody composition and foo...ges 107-117, they foundthat heterozygous motheaten mutants
-- which lack one copy of SHP-1 --exhibited elevated levels of Th2 differentiation and Th2-specific ...
Prion disease may be caused by buildup of cellular trash, say Stanford researchers
...m degeneration and body tremor. Because mahoganoid mutants
share their darkened coat color with Attractin mut...ne responsible for the mayhem, they found that the mutants
were unable to express a ubiquitin ligase they named Mahogunin. Mahogunin was also identified late l...
The making of a brain
... of mouse Six3 messenger RNA in headless zebrafish mutants
effectively down-regulated Wnt1 expression and rescued the headless phenotype. "It is clear that small differences in the expression of Wnt proteins along the future brain region are critical for the determining the final identity of the different b...
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