National Jewish faculty to present research at American Thoracic Society
...most all of the RGM-infected patients had only one mutated gene, which is not otherwise associated with disease. Iseman and his colleagues suspect that anomalies of the alpha-1 antitrypsin system predispose patients to NTM disease. Abstract: http://www.abstracts2view.com/ats/view.php?nu=ATS3L_5309 Cystic...Virus researchers close in on the secret life of DNA
...modified protein were still lethal. Next, the team mutated the modified protein and found that mutations that affected the active site and the protein's ability to bind to Z-DNA in the test tube diminished the virus's lethality, much as mutations to E3L's active site had earlier been proved to disable the vi...Hopkins scientists uncover role of Fanconi's Anemia genes in pancreatic cancer
... that about 1 in every 300 people have inherited a mutated copy of at least one FA gene. "Our findings also tell us that cancers that appear to occur randomly in the population may not always really be so random," Kern says. "It is likely that the origin of many cancers could be traced back to similar in...Secrets of drug resistance in bacteria
...rap and pump out toxic bile salt. Unfortunately, a mutated form of Escherichia coli causes food poisoning. And, making matters worse, AcrB shields the bacteria from many more compounds in addition to bile salt, which explains why a broad regimen of antibiotics is needed to fight the infection. "The protein ...Systematic analysis of gene family uncovers new therapeutic targets for colon cancer
...on. Although a few TK genes have been shown to be mutated in specific cancers, until now, no study has revea...or-class compounds that block the proteins made by mutated TK genes have been shown in both human clinical trials and animal studies to halt the cancer process...UI researchers discover new cause of muscular dystrophies
... critical role. The protein, called dysferlin, is mutated in two distinct muscular dystrophies known as Miyoshi Myopathy and limb-girdle muscular dystrophy type 2b. The UI study suggests that in these diseases, the characteristic, progressive muscle degeneration is due to a faulty muscle-repair mechanism ra...Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration
...ilar technology, both research groups identified a mutated gene which provides an answer to this question." T... groups performed positional cloning to locate the mutated gene responsible. The collaborative research began with the further biological analysis of the two ...St. Jude researchers reverse blood disease using genetically modified stem cells
...ical protein called beta-globin or that contains a mutated form of the protein. Hemoglobin is the oxygen-carrying protein in red blood cells. Replacing red blood cells that carry defective hemoglobin with red cells that have normal hemoglobin is a potential strategy for curing these disorders. Beta thalasse...Borrowing from Ebola virus could aid cystic fibrosis gene therapy
...ere the genes needed for healthy lung function are mutated or absent. "Most people understandably do not think of the Ebola virus in a favorable light, but our approach takes a small part from this bad virus and puts it in a hybrid system to get some good out it," said Paul McCray, M.D., UI professor of pedi......d human genomes, respectively. As the myc gene is mutated in approximately one-third of all human cancers, the identification of the full range of genes that interact with Myc under normal conditions will be important to understanding how abnormal myc expression can lead to cancer. The myc gene encodes a tr...Gene discovery may shed light on carpel tunnel syndrome and Lou Gehrig's disease
... is so fundamental to biological processes--can be mutated in a fashion that results in a highly discrete neu...our disease-related mutations and speculate that a mutated copy of GARS leads to a reduction in the activity of the gene's enzyme product. More research into ...Missing protein is double-edged sword in cancer development
...increase the potential that a mutated cell would divide, and the resulting mutated cells could spread throughout the body. "The loss of E2F3...Process triggered by some anti-cancer drugs causes tumors in mice, study finds
...tissue sarcomas earlier when compared to similarly mutated mice with normal methylation levels. In these mice, Eden could show that hypomethylation-induced chromosomal instability caused an increase in tumor formation. The instability could be an asset to a cancer cell looking to multiply and cause trouble,...Patent issued to U-Iowa for mutant chicken pox virus
... a second, isolated case of the chicken pox having mutated on its own. "The fact that the mutation was found a second time in the same site in the same gene but in a different person made us think that it is scientifically unlikely that in a virus containing 70 genes that the exact same mutation just happene....... Zhu and colleagues cloned the gene that had been mutated in this plant, and named it ICE1 (inducer of CBF expression). Further research by the group revealed that ICE1 is also a transcription factor: During periods of cold stress, ICE1 binds to and turns on the CBF3 gene, which, in turn, induces the expres...Widespread cannibalism may have caused prehistoric prion disease epidemics, Science study suggests
...etermined that people with one normal copy and one mutated copy of the prion protein were somehow protected against Creutzfeld Jacob disease. The mutation consisted of a single amino acid substitution at a certain spot in the gene, and is known as "M129V." Among the Japanese and other populations in the Indi...OHSU scientists define adult stem cell healing abilities
...od for introducing new genetic material to correct mutated or malfunctioning genes that cause disease....Screening technique streamlines search for anticancer drugs
...hat become active only in the presence of commonly mutated genes," says Stockwell. "We've identified several compounds, including one previously unknown compound, that had exactly the effect we were looking for." Mass screening like this--what scientists call high-throughput testing--represents a new and eme...Researchers develop strategy to predict mutations involved in cancer drug resistance
...ariations that might be found in CML patients. The mutated genes were then transferred into millions of mouse blood cells and exposed to Gleevec. While most cells succumbed to the drug, some of the cells with specific variations thrived. "We looked for those cells that continued to grow, extracted them and ...Researchers discover strategy that shields HIV from destruction
...in the shield. But by then, the virus has randomly mutated its glycan shield, as well as other regions of the envelope, to uncover different working areas, conferring a strong survival advantage to viral particles that cannot now be "seen" by antibodies, which also change their structure in pursuit of the vi...