Gene that drives cells to commit suicide also plays key role in development of skeletal muscle
...ests that future research might offer clues to how mutated forms of this molecule cause a form of muscle canc...le of FKHR in myoblasts could help explain how the mutated FKHR genes cause cancer, according to the St. Jude researchers. The study shows that FKHR not only h...Are we mice or men? Gene mutation linked to improving heart failure in mice proves lethal in humans
...t failure, the researchers reveal that humans with mutated forms of PLN develop lethal heart failure. Heart failure is a leading cause of human morbidity and mortality worldwideand costs close to $18 billion in health-carerelated costs in America eachyear. Characterized by suppressed calcium cycling in the h...Study pinpoints regulator of imprinted gene expression
... (a rare neurological disease) have found that the mutated gene exerts its effect by influencing epigenetic m...herited from the mother or the father. When Eed is mutated or its function impaired, loss of imprinting can occur - both the maternal and paternal copy become ...Mutants from a lowly weed may solve maladies
...rticular portion of the Arabidopsis, then grow the mutated plant to see how it reacts to various conditions compared to "normal" Arabidopsis plants. In Koiwa's case, the condition of choice is salt stress. High salt levels are found in one third of the world's cropland and that means reduced yields, accordin...New Jersey chemist wins national award for drug discoveries
...uch as Ganguly's work to block the activation of a mutated protein that can cause cancer. One such candidate developed by his research team at Schering-Plough, where Ganguly was senior vice president of chemical research, is currently in clinical trials as the drug Sarasar. And third, one can start with the ...Stanford research points to chance as cause of genetic diseases in Ashkenazi Jews
... sickle cell anemia, in which people who carry two mutated copies of the gene have a disease, but those who inherit one copy of the mutation are protected against malaria. Those people - called carriers - are more likely to be healthy, have more children and pass their mutation on to future generations. If ...Dartmouth Medical School geneticists discover new role for antisense RNA
..., the researchers determined. However, in strains mutated to abolish induction of antisense frequency RNA by light, the internal clock time was delayed, and resetting of the clock by light was altered. If similar environmental factors regulate both sense and antisense transcripts, the authors suggest, a rol...Fetal death, miscarriage linked to genetic mutation
...ease in the amount of essential fatty acids in the mutated mice compared with the normal ones. The fatty acid...functioning. In other words, could we create an Rb mutated mouse with a normal placenta? It turns out they could. Through two separate and very different exper...Study may help explain sunlight's role in melanoma development, have screening implications
...ecific molecular pathway within cells that becomes mutated by ultraviolet light exposure, thereby speeding up melanoma development. New findings published in the Feb. 4 issue of Proceedings of the National Academy of Sciences may have implications for screening people at high risk, including those "with ...Pavlov's flies: Researchers identify fruit fly memory mutants
...when genes identified by the DNA chip approach are mutated or switched off in flies, the resulting flies fail to form long-term memories. The study, by Cold Spring Harbor Laboratory neuroscientists Tim Tully and Josh Dubnau, reveals new roles for nearly 100 genes in memory, as well as a role in memory for a ...Modified zebrafish may point the way toward T cell leukemia genes, aid in drug development
...en thousands of zebrafish genes for those that, in mutated form, contribute to the disease. Although Myc is involved in the cancer process, it does not act alone. It works in concert with other genes - a so-called molecular "pathway" - to drive cancer development. The goal is to find those other abnormal ge...Computer scientist locates more than 1,000 novel genes in mouse and human
...re a new relative of the dystrophin gene, which is mutated in Duchenne muscular dystrophy, a number of genes involved in neural development, and several immune system genes. There are between 25,000 and 30,000 genes in both the human and mouse genomes, with no more than 500 genes separating the two mammals....Scripps scientists discover new approach for treating 'misfolding diseases'
...ed of mutant and normal subunits. The inclusion of mutated subunits makes the tetramer less stable and causes the four subunits to more easily dissociate. Once the subunits are free, they misfold and reassemble into the hair-like amyloid fibrils.These fibrils cause the disease FAP by building up around perip...Protein linked to movement disorders
...l Research Foundation, the scientists found that a mutated gene associated with early onset dystonia, a sever...er, normally helps manage protein folding. The mutated gene, TOR1A (or DYT1), was linked to the disorder in 1997, but the role of its protein, torsinA, had...Coat-color gene mutation mimics neurodegeneration of prion diseases
... "It was satisfying to find that the gene that was mutated in mahoganoid had a biochemical activity that could help explain the pathophysiology of the neurodegeneration that we were seeing," said Barsh. Further experiments revealed evidence that the Attractin protein -- which is a receptor-like protein -...New study shows tea extract protects skin
...r watchdog cells, essential in detecting germs and mutated proteins produced by cancerous cells; but, because of their location, the Langerhans cells are very sensitive to damage by sunlight. Scientists in the study found the white tea extract protected against the Langerhans cell obliteration that was obse...Newly discovered cellular process helps cells respond to DNA damage
...lay important roles in preventing cancer, and that mutated forms of Brca1 and p53 are responsible for inherited cancers, such as familial breast cancer. The new St. Jude findings thus provide new insights into the way cells signal to both Brca1 and p53 following DNA damage. The scientists are hopeful that th...UW researchers discover gene mutation associated with a form of Charcot-Marie-Tooth disease
... degrading other proteins. The disease role of the mutated gene in the 1C form of Charcot-Marie-Tooth is unkn...ritical to peripheral nerve function, and that the mutated gene may not be able to carry out this function efficiently. Further studies of the mutated LITAF ge...UCSF study of ancient fly gene offers insights into male fertility
...st in sperm development. Identification of such a mutated gene could lead to the development of drugs that would assist the immature sperm cells in finishing meiosis, thereby overcoming infertility. On another front, the human BOULE gene could prove a target for a male contraceptive, says Xu. While the adul...Researchers discover protein defect linked to gastrointestinal cancer
... gastrointestinal cancer. The defective protein, a mutated form of the enzyme platelet-derived growth factor ...h OHSU researcher Brian Druker, M.D. It targeted a mutated enzyme driving the uncontrolled growth of white blood cells. Because this enzyme is structurally sim...