Tag: "mutation" at biology news

Genetic mutations linked to the practice of burning coal in homes in China

...e for p53 mutations, one tested positive for K-ras mutation and one tested positive for both p53 and K-ras mutations. According to Dr. Keohavong, also a faculty member at the University of Pittsburgh Cancer Institute, these findings are similar to other studies in which he and colleagues found that the frequ...

Researchers determine genetic cause of Timothy syndrome

..., 2004, issue of the journal Cell, that a pinpoint mutation in the CaV1.2 calcium channel was the sole cause o...evealed that it was not inherited, but caused by a mutation that occurred spontaneously. Eventually their analyses of a multitude of genes revealed that in all ...

Rare childhood genetic syndrome identified

...rises from a single, spontaneous, very subtle gene mutation in the mother's egg or father's sperm substitutio...e reason so many body systems are affected is that mutation impairs a very fundamental molecule a type of calcium channel that is found in many tissues and or...

Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases

... which encodes a protein called Internalin B. This mutation was made at Cerus using Portnoy's methods in order to prevent direct invasion of liver cells, thus dramatically lowering liver damage by the vaccine strain. Cerus plans to use this doubly attenuated listeria strain as a platform for various types of ...

New research shows plants can shuffle and paste gene pieces to generate genetic diversity

...s the duplication of an existing genes followed by mutation of one of the pair until it evolves into another function, though this is not the usual fate because the duplicate copy usually mutate into oblivion." The discovery of thousands of Pack-MULEs in the rice genome indicates that this may be an imp...

$2.7 million grant to support creation of virtual zebrafish atlas

...el to study the relationship between high rates of mutation and the development of cancer. "Zebrafish are becoming an ideal research model to determine the functions of individual genes in vertebrates and the timing of gene expression during development in the context of a whole, living organism," Cheng said....

Experimental drug shown to block mutant protein causing blood disease

...d kinase, FGFR1, which is inhibited by PKC412. The mutation occurs when two broken pieces of the chromosome that carries the FGFR1 gene join together abnormally. The findings suggest, the authors write, that PKC412 may be effective in treating MPD, as well as other diseases and cancers where mutant FGFR1 is t...

'Fossil genes' reveal how life sheds form and function

...blocks of all genes - have been edited out through mutation to terminate the physiological message they were responsible for transmitting along the pathway. "Genes become fossilized if there is no use for them," says Rokas. "If you relax the pressure on the genes to zero, mutations will begin to accumulate. T...

Research suggests new avenue for stopping, preventing colon cancer

...t study tested the effect of PGE2 in mice with the mutation that made them susceptible to polyps. Administrati... drug was given to a strain of mice with a genetic mutation that makes them susceptible to developing pre-cancerous intestinal polyps, both the number and size ...

Genes expose secrets of sex on the side

...f the Y chromosome by suggesting that a beneficial mutation on the Y had swept through the whole world. Howeve...ntradicts those ideas. If a beneficial mutation had swept through the males, men's common paternal ancestor would be the same age no matter where th...

JCI table of contents September 15, 2004

...e, if the fused cells are no longer defective, the mutation is in the patient's nuclear DNA. If the fusions remain defective, the causal mutation is likely to be in the mitochondrial DNA. This technique is a very rapid and powerful means to cate...

Human chromosome 5 final sequence analysis released to public

...Schmutz, the informatics group leader at SHGC. Any mutation that appeared in those conserved regions was likel... or made it less able to reproduce, preventing the mutation from making it to the next generation. So far, nobody has shown what role the conserved regions play...

Venn diagram tactics to vet complex disease

...e, if the fused cells are no longer defective, the mutation is in the patient's nuclear DNA. If the fusions remain defective, the causal mutation is likely to be in the mitochondrial DNA. This technique is a very rapid and powerful means to cate...

Can an old gene learn new tricks?

...es in new parts of the embryo, rather than through mutation of gene protein-coding sequence alone. Old genes can be given a new purpose through 'reassignment' to organs undergoing evolutionary advancement. The reassignment likely comes through a shuffling of existing regulatory elements to generate new combi...

Spontaneous mutation produces new MAO A/B knockout mouse

...the matter, Dr. Shih determined that a spontaneous mutation in a single nucleic acid base pair in the MAO A ge...to a protein. The scientists hypothesize that the mutation was due to elevated levels of the MAO B substrate phenylethylamine in the MAO B knockout mice. Pheny...

Researchers discover why mutant gene causes colon cancer

.... The lifetime risk for people with this inherited mutation is 100 percent. Scientists have since determined that an acquired mutation of the APC gene is also found in 85 percent of sporadic colon cancer. Colon cancer is the number two...

Breaking new ground in germ cell guidance

.... Hanyu-Nakamura et al. pinpointed the site of the mutation to the locus for the guidance gene, wunen2 . The products of this gene and its relative, wunen , have been known for some time to play important roles in the guidance of Drosophila pole cell migration by somatic cells. The genes encode lipid phosphat...

New evidence of radiation risk in childhood leukaemia

...ognised that ionising radiation not only increases mutation rates in the exposed somatic cells but also results in an elevated mutation rate many cell divisions after the initial irradiation damage. Yuri Dubrova, Professor of Genetics ...

Heart gene yields insights into evolution, disease risk

...s' detailed molecular understanding of the genetic mutation underlying a disease and the evolutionary biologis...ural selection acted on the gene to propagate that mutation in the population. Said Rockman, "Our research, and that of other evolutionary biologists, is direct...

Recent evolution at a single gene may have brought down heart disease risk in some human groups

.... The researchers' new work also showed that the mutation that created the variant occurred at a site unusually prone to genetic change. By comparing human DNA with that of a diverse range of other primates, they showed that the variation in heart disease susceptibility is partly attributable to a so-called...

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