Survey reports fall in stem cell transplants for breast cancer
...lignancies, such as relapsed lymphoma and multiple myeloma where survival can be prolonged, data supporting a beneficial role for autologous transplants in most solid tumours are lacking." The survey identified different trends over time for autologous transplants in different cancers a continuing steady in...Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
...py in clinically relevant mouse models of multiple myeloma and other hematological malignancies. The researchers also identify two small molecules that are selective inhibitors of IGF-1R and are active anticancer agents against tumors that contain IGF-1R. These small molecules represent highly attractive p...Origin of multiple myeloma found in rare stem cell
...l types. In their studies to learn why multiple myeloma so often recurs following drug treatment, the inve...every 10,000 cells or less than one percent of all myeloma cells. Working with immune system B-cells, the Johns Hopkins team found that this stem cell ...White House awards National Medal of Science to Rockefeller University's James Darnell
...logy of specific human cancers, including multiple myeloma and head and neck tumors. "This discovery has promoted a flurry of research into the ways cells receive signals to become and remain specialized, to respond to growth factors and to deal with infection," adds Nurse. Darnell is the third Rockefeller ...U of MN researchers find genetic variations may predict treatment responses for myeloma
...termine the outcome and toxicity of treatments for myeloma cancer patients. The findings support thinking tha...though chemotherapy drugs can be effective against myeloma in many patients, they can be less effective or even lethal in others. By determining a patient's to...Genetic differences revealed by SNPS play a role in risk, prevention and outcome for cancer
...etermine the outcome and toxicity of treatments of myeloma patients. Another study, conducted by scientists with Children's Cancer Institute for Medical Research in Sydney, Australia, revealed that children with a particular gene variant may contribute to an improved response to chemotherapy, and hence decre...Research shows bortezomib benefits a third of multiple myeloma patients
...shows promise for treating patients whose multiple myeloma no longer responds to conventional chemotherapy, a...compound, researchers found, including seven whose myeloma protein became undetectable and 12 whose telltale protein could be found only with a special test ca...Clinical study reports findings of combination therapy with DOXIL
...methasone, known as DVd, in patients with multiple myeloma were published in the November 15, 2002 issue of t...ete response, defined as complete disappearance of myeloma protein from the serum and urine by immune fixation, a bone marrow biopsy demonstrating less than 3%...Technique brings immune-based therapies closer to reality
...r vaccines" in patients with melanoma and multiple myeloma and as virus fighters after bone marrow transplant. However, the technological advance reported by the Johns Hopkins team overcomes a major weakness of current methods for making these targeted immune cells, known as antigen-specific cytotoxic T c...Sequence matters when using novel agent
...d 70 percent of 78 patients with advanced multiple myeloma improved - an unheard of benefit in that disease. The agent is now being used in a Phase II clinical trial in advanced prostate cancer, and several Phase I clinical trials are underway, or have been completed, testing PS-341 in pancreatic, lung and c...MNI-McGill researcher first to discover that normal nerve cells can mimic viruses
... been correlated with two human diseases- multiple myeloma and Charcot-Marie-Tooth disease. This is the first time that scientists have demonstrated that normal nerve cells can use an IRES to produce large quantities of protein under physiological conditions. Dr. Sossin and colleagues made their discovery...UT Southwestern researchers developing new procedures to make bone-marrow transplants safer
...al types of cancers, including leukemia, lymphoma, myeloma or aplastic anemia. Occasionally, those with certain genetic diseases of the blood (such as thalassemia, sickle-cell disease and severe combined immunodeficiency) receive transplants. "If you can eliminate graft-versus-host disease but retain or even...Prize to Weizmann Institute professor for landmark work in stem cell transplantation
...people with leukemia, malignant lymphoma, multiple myeloma and congenital blood disorders, such as halassemia or severe immune deficiencies. Reisner's research, conducted in collaboration with a team led by Prof. Massimo Martelli of Italy's Perugia University has revolutionized transplantation therapy, ena...FDG PET reassures and reveals high risk multiple myeloma
...ecome active disease for 66 patients with multiple myeloma and related conditions studied by researchers from...in by abnormal plasma cells, evolves into multiple myeloma about 20% of the time. All had negative PET scans at their first evaluation. Only one of the patien...New test identifies B-cell tumor markers
Orlando, FL In the United States, multiple myeloma accounts for about one percent of all cancers, and...., July 28-August 1, 2002. Background Multiple myeloma is a plasma cell cancer in which a clone of abnormal plasma cells multiplies, forms tumors in the bo......d the same type of gene modification in a multiple myeloma cell line. That leads researchers to question whether this type of gene modification goes beyond the specific AIDS-related lymphomas found in this research. This could be a general phenomena found in more than one form of cancer, Teitell said. It may...Cell Genesys reports antitumor activity in Phase I/II GVAX lung cancer vaccine trial
...itionally, a Phase I/II trial for GVAX vaccine for myeloma was recently initiated, and a Phase II trial of GV...rostate cancer, pancreatic cancer, lung cancer and myeloma and expects to initiate new studies in acute leukemia during 2001. Preclinical stage programs incl...LDP-341 Press release and fact sheet on multiple myeloma : -Clinical and preclinical data presented ...ompound, showed in vitro activity against multiple myeloma cells, resulting in the inhibition of cancer cell growth and reproduction, and the inducement of cel...Long-term data on Dendreons Mylovenge vaccine presented at American Society of Hematology
...sco. The trials, involving patients with multiple myeloma and with amyloidosis, indicate that Mylovenge caus...incipal investigator of studies involving multiple myeloma and amyloidosis patients by and Dr. Malcolm MacKenzie, director of the Sacramento Medical Foundation...