Tag: "myocytes" at biology news
JCI table of contents September 15, 2004
...id also occur in a small fraction of donor-derived myocytes
at the graft-host border. EGFP-marked donor myobla...e, where histology demonstrated a small portion of myocytes
expressed both donor- and host-derived transgenes, indicating fusion of these cells. These double-ex...
Researchers-again-pinpoint why stress kills
...sed to CMS. Aconitine is arrhythmogenic in cardiac myocytes
due to enhanced sodium influx into myocardial cells on both depolarization and repolarization and as a result of an increase in active Na+ current during depolarization. The utility of aconitine for the study of electrocardiographic activity is well ...
Evidence shows the heart has stem cells able to regenerate muscle tissue lost to disease, wear
... Nadal-Ginard. Scientists reasoned that if no new myocytes
could be generated in adult hearts, then all thera...l or pathological stress. Furthermore, if no new myocytes
were being generated, that by definition meant all the body's heart muscles had to be the same age. ...
Stem cells put to the test in UNC studies
...re not made "in vivo," in a living animal, the new myocytes
were rhythmically beating and "were functionally integrated with the adjacent heart cells," Cascio said. "They demonstrated intact cell-to-cell communication with cell-to-cell transmission of calcium signals." Cascio added that the study confirmed ...
Bioengineered, rhythmically beating heart muscle could aid cardiac research
...Cascio very astutely thought we could grow cardiac myocytes
and make a cardiac muscle tissue-like material to ...ratory assistant Joseph Brackhan, isolated cardiac myocytes
from one-day-old rats. These were mixed in a solution of collagen and serum and allowed to gel unde...
The MAP kinase pathway in coxsackievirus infections
...can infect lymphocytes and macrophages, as well as myocytes
and other cell types in many organs. In some humans and in particular strains of mice, infection of the heart provokes dilated cardiomyopathy and can lead to heart failure. Earlier work showed that the MAP kinase signaling is induced by infection and...
A pilot study may offer promise of a marker for ovarian cancer
... the fluids and tissues. ANP is secreted by atrial myocytes
as a 126 aminoacid molecule and divided into different fragments, namely proANP(1-30) (NtANP), proANP(31-67) (mdANP), proANP(79-98) and the active ANP(99-126). Similar properties have been reported in previous research studies for ANP and proANP-(1-...
Fas signaling and cardiac hypertrophy
... apoptosis. Evidence for Fas activation in cardiac myocytes
subjected to pressure overload is therefore not su...rexpression of the Fas ligand (FasL) does not kill myocytes
but rather leads to a metabolic and morphological transition reminiscent of the adaptive hypertrophy...
Cholesterol-independent benefits of statins in cardiac hypertrophy
... hypertrophy. The hypertrophic response in cardiac myocytes
entails not just an increase in cell size, but also a reversion to a pattern of gene expression normally seen only in early heart development. Statins, which block mevalonate biosynthesis, prevent cells from producing a variety of this lipid?s metabo...
Scientists find that heart muscle cells regenerate after a heart attack
...scular Research Institute, and colleagues, studied myocytes
(heart muscle cells) from the hearts of 13 patient...became functioning heart muscle by developing into myocytes
and coronary vessels. Moreover, the newly formed tissue partially restored the hearts ability to pu...
How fat kills heart cells
...ored lipids accumulate in the cytoplasm of cardiac myocytes
in a variety of cardiomyopathies, ranging from suc...f enzyme overexpression. In these animals, cardiac myocytes
die through apoptosis and necrosis, and those cells with with large lipid inclusions are lost prefer...
Heart cells closely control their own oxygen supply
...ck. But the current studyis the first to show that myocytes
also will not tolerate high levels of oxygenassoci...optimal oxygen concentration in the blood reaching myocytes
is about 6percent, the study reveals, and the permissible window is quite narrow - onlyabout 1 perce...
UCSF/Gladstone Finding May Explain HIV'S Ability To Infect Cells Lacking The Key Target Of HIV: The CD4 Receptor
...s in the brain; epithelial cells in the colon; and myocytes
in heart tissue. While CD4-negative cells are not the principle target of HIV infection, studiesindicate that these cells, when infected, may be the underlying cause of somelethal HIV-associated diseases, including HIV-associated dementia andHIV-asso...
A Protein Switch May Turn On Heart Cells To Combat Heart Disease
...t attack, or in response to stresses on the heart, myocytes
willget bigger. However, these bigger heart cells don't work as well," says W. RobbMacLellan, M.D., assistant professor in the Cardiovascular ResearchLaboratories at the University of California at Los Angeles School of Medicine. "We're trying to ...
Circulatory Device -- A Bridge To Recovery For Heart Failure?
...s. "These results clearly demonstrate that failing myocytes
can regain some degreeof their previously normal f...py and,most important, whether the improvements in myocytes
are lasting or transient.If improvement persist, LVADs may not just be a "bridge to transplantation"...
Possible Trigger For Heart Failure Identified In Lab Animal Studies
...fpediatrics. "Production of TNF by cardiac myocytes
is sufficient to causemyocarditis, myocardial dysfunction, cardiac failure and premature death, andtherefore supports a causal role for TNF in the development of diverse cardiacdiseases," she says. Previous research on congestive heart failur...