22-amino acid bacterium created by Scripps scientists
...y engineered this modified form of E. coli to make myoglobin proteins with 22 amino acids -- incorporating the unnatural amino acids O-methyl-L-tyrosine and L-homoglutamine in addition to the naturally occurring 20. Scientists have for years created proteins with such unnatural amino acids in the laboratory,...Scientists at Scripps Research describe new strategy for the synthesis of glycoproteins
... E. coli to make homogeneous pools of glycosylated myoglobin protein with sugars attached at one desired positi...xtra sugars. The use of E. coli to make the myoglobin is a significant advance because it is a general and versatile method and it opens up the gates for ...Researchers view protein's structural changes in real time
...d. For the study, the researchers used a mutant of myoglobin developed in the lab of John Olson at Rice, becaus...lished the first nanosecond time-resolved study of myoglobin in 1996. The time resolution of the current work is 50 times better, and the improved spatial resol...Scientists discover chemical switch that determines muscle fiber type
...ocess turned on by PGC-1 produces proteins such as myoglobin that slow-twitch muscles require. Spiegelman, Jiandie Lin, PhD, the paper's first author, and their colleagues created transgenic mice that carried the PGC-1 gene in all their skeletal muscles. An added bit of DNA, called a promoter, caused the PGC-1...Evolutionary implications: myoglobin-like proteins found in ancient microorganisms
...ke proteins in ancient microorganisms. In animals, myoglobin (found in muscle) and its close relative hemoglobin (the main protein in the red blood cell) play an essential role in oxygen transport and storage. The newly identified proteins may be the evolutionary ancestors of proteins involved in oxygen sensin...Oxygen-Carrying Myoglobin Not Necessary For Survival
...ontinuefunctioning. "We still believe that myoglobin is important, but something else isalso important; there are some cellular adaptations that we have not yetdefined," Garry said. "By understanding and identifying these adaptations, wewill increase our knowledge of what happens when people get chest ...Lights, Camera ... Reaction: Charting The Biological Effects Of Light InBillionths Of A Second
...ed the firstnanosecond movie of the muscle protein myoglobin as it opened up to releasecarbon monoxide. Today's report emphasizes the wider applicability of this newtype of measurement. Keith Moffat, Ph.D., professor of biochemistry and molecular biology anddirector of the Consortium for Advanced Radiation Sou...