Gene Therapy Animal Study Offers Hope For Some Neurodegenerative Diseases
...hat disruptprotein production, can be used to slow neurodegeneration in an animal model,signalling a possible approach for overcoming one of the monumental hurdles ofgene therapy. In the study, reported in the August issue of Nature Medicine, researchersdemonstrated that ribozymes could be used to reduce the productio......interfacebetween nutrition and neuroscience," says neurodegeneration expert Joseph Coyle,MD, of Harvard Medical School. "Very little is published on this area." In the study, the researchers found that eating the daily equivalent ofa pint of strawberries or a large spinach salad reduces specific effects ofbra...Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
...ts for these diseases, and theunderlying causes of neurodegeneration remain obscure," said Dr. Cox, a ResearchScientist in Dr. Frankel's group. "Mouse models of human disease like nmdprovide unique tools for both gene discovery and analysis of underlying diseasemechanisms. Our findings provide an additional tool for u...University of Colorado salmon study spawns new insight into human brain aging
... specific brain regions of spawning salmon exhibit neurodegeneration and amyloid plaques remarkably similar to those in humans. But other brain areas used for migration and spawning tasks continued to function, despite the presence of beta-amyloid plaques, Maldonado said. Olfactory regions of the brain, for example...Science: Prion proteins may signal trouble -- literally
...m (PrPS c ) wrecks cellular processes, causing the neurodegeneration of scrapie. The non-pathogenic prion protein is not known to play a role in a specific cell function, researchers said. But, normal prions may fine-tune neuronal functions at the cellular level, since they are sited at nerve-cell surfaces, particul...UK researchers find critical link for estrogens neuroprotective effects
...ainst brain injury (including injury from stroke), neurodegeneration and cognitive decline. The UK College of Medicine research team examined whether estrogen receptors are critical for estrogens neuroprotective effects. The team focused on two estrogen receptor types, ERa and ERb. Using animal models in which on...USF Alzheimer's vaccine research boosted by $1.1-million NIH grant
...s will inject the mice bred to develop age-related neurodegeneration with the anti-Alzheimer's vaccine, which contains as its antigen a synthetic version of beta amyloid, the protein that builds up in the brains of Alzheimer's patients. Then, they will analyze the responses of immune cells to the vaccine. They will lo...Leprosy bug provides clues to early nerve degeneration
...is may unravel clues for early molecular events of neurodegeneration processes in other diseases, such as multiple sclerosis, which we currently know littleabout." "By using this bacteria we will be able to obtain novel insight not only into the mechanism of the early demyelination process, but also how the complex mo...New robotic microscope helps scientists track cells over time
...know how it causes individual neurons to die. Does neurodegeneration result when the mutant huntingtin molecules clump together to form aggregates? Or does the mutation cause harm by changing the activity of huntingtin molecules that are not tangled up in the aggregates? To answer those and other questions, Finkbeiner...Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration
... in the journal Nature, provide a genetic model of neurodegeneration mediated by oxidative stress. They also demonstrate a direct connection between cell cycle re-entry and oxidative stress in an aging central nervous system. To date, ALS is the one neurodegenerative disorder known to be caused by oxidative damage to ...Researchers find mechanism responsible for neuronal death in prion diseases
...ured cells and transgenic mice. Mice suffered from neurodegeneration and loss of muscle control, similar to patients with CJD and other prion diseases. PrP normally sits on the cell surface. But if it misfolds before it gets to the surface, the cell's quality control mechanism sends it to the cytosol for destruction...Coat-color gene mutation mimics neurodegeneration of prion diseases
...tions affected not only hair color but also caused neurodegeneration with a phenotype very similar to that caused by th...that could help explain the pathophysiology of the neurodegeneration that we were seeing," said Barsh. Further experiments revealed evidence that the Attractin protein...Mouse genetic model for spongiform brain diseases
...levated, Gunn explains. Furthermore, this form of neurodegeneration is not known to be contagious, Gunn says, noting: "A cat that eats a mahoganoid mutant mouse -- should one escape from the laboratory -- would not get spongiform encephalopathy." The researchers were looking for effects that might be linked to muta...Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration
...e, could significantly impact our understanding of neurodegeneration in general," commented Dr. Gabriele Stumm, study co-author and Director of the Neurobiology Program at Ingenium. "The key discovery is that an inherited moderate impairment of nerve cell transport functions indeed can result in age dependent distinc...Stem cell death gives clue to brain cell survival
... number of endogenous stem cells. "Also during the neurodegeneration that occurs in diseases such as Alzheimer's and Parkinson's, we have a lot of cell death going on and we would like to know what signals are involved that make those brain cells die. They may be very similar or even exactly the same as the ones we in...JCI Table of Contents, September 15, 2003
...ored impaired brain function and protected against neurodegeneration and motor skill abnormalities. D-beta-HB, already ...neurotoxin MPTP to mice, which caused dopaminergic neurodegeneration and deficits in the mitochondrial electron transport chain reminiscent of Parkinson disease. Using t...Easily paralyzed flies provide clues to neurodegeneration
...heir collection undergo progressive, age-dependent neurodegeneration resulting in the widespread death of brain cells. ... valuable new insights into the molecular basis of neurodegeneration in both flies and humans." Ganetzky believes his collection of fly models, which has been licens...JCI Table of Contents, January 15 2004
...d during the course of the disease are involved in neurodegeneration by causing apoptosis of the neuron. The data also provide a target for the development of novel therapies. TITLE: Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses AUTHOR CONTACT: Shoji Yamanaka Yokohama City University Sc......ing the normal prion protein triggered the type of neurodegeneration that characterize BSE and variant Creutzfeldt-Jakob. This suggests a possible mechanism for prion pathogenesis-- that scrapie prions cross-link normal cellular prions, killing neurons in the process. Rather than being innocent bystanders un......: Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia AUTHOR CONTACT: K. George Chandy University of California, Irvine, Irvine, California, USA. Phone: 949-824-6370 Fax: 949-824-3143 E-mail: gchandy@uci.edu View the PDF of this article at: https://www.the-jci.org/press/202...