Tag: "neurological" at biology news

UPMC Reports On New Liver Assist Device

... monitor the clinical stability of patients, their neurological status, anddevelopment of infection. Researchers also hope to gain insight about thedevice's impact on treating liver failure, although a second trial would need tobe conducted to thoroughly study its treatment efficacy. "We are very encoura...

New Clue To apoE Function

...d the onset of Parkinson's disease and bodes apoor neurological outcome after cardiac bypass or cerebral hemorrhage. "Our thinking is that apoE3 is much more effective at promoting regrowthof nerve cell extensions after injury," says David M. Holtzman, M.D., assistantprofessor of neurology and molecular b...

Researchers Identify Function Of Brain Receptor Subunit Linked To Memory, Stroke, Dementia

...herapy to protect nerve cells from injurycaused by neurological diseases." For Nakanishi, the knockout mouse holds promise as the first animalmodel for synaptic plasticity. Activation of the NMDA receptor determineswhether neuronal activity is worthy of memory. He plans to further study therole of NMDA re...

Mouse Model Of Down Syndrome Offers Glimpse Into Role Of Specific Genes In TheDisorder

...mosome 16 that has strong parallels to some of the neurological disorders ofthe disease in humans. And this, said Huang, should make it easier to zero inon the role of individual genes. Another previous standard model, Ts65Dn, includes a slightly larger thirdsegment of chromosome 16 and causes more widespread le...

Gene Discovery Provides Insights Into Epilepsy

...seconds, they experience each hour. Epilepsy is a neurological disorder that occurs in about 20 forms and affectsapproximately one percent of the U.S. population. Absence, or petit mal,epilepsy occurs primarily in children and its seizures are characterized bybrief lapses in consciousness during which a person a...

Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy

...luding epilepsy, in humans." Epilepsy is a neurological disorder that affects approximately onepercent of the U.S. population and has two major forms: absence (petit mal) andconvulsive (grand mal). Absence seizures primarily occur in children and arecharacterized by brief lapses in consciousness during wh...

DNA Vaccine 100 Percent Effective Against Rabies In Monkeys

...tries, derived in animal brains, often causesevere neurological side effects such as allergic encephalitis, which can leadto paralytic reactions as well as death. "About three years ago," says Dr. Lodmell, "I became very interested in DNAvaccination, and thought it was a logical step for the rabies problem." DNA...

Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway

...treating avariety of acute and chronic age-related neurological diseases, includingAlzheimer's disease, Parkinson'... this pathway may be a viable strategyfor treating neurological diseases that involve apoptosis." "This is the first report in the scientific literature describing ...

Vertex Researchers Report Three-Dimensional Atomic Structure Of JNK3 Enzyme; Report In Structure

...K3 stemsfrom animal studies that implicate JNK3 in neurological diseases such asepilepsy. Genomic research has shown that mice bred to be deficient in JNK3show reduced susceptibility to seizure and neuronal cell death. Vertex's has an established track record of applying structural information togenomic discov...

Persistent Organic Pollutants, The Danger Is Not Over

...small doses of toxic pollutants can cause lifelong neurological disturbances in laboratory animals. Ten day-old mice exposed to a few micrograms of DDT will suffer permanent damage to the central nervous system. There are no external changes, but for the rest of their life they will endure red...

Commercial Fish: Eat Up, Despite Low Levels Of Mercury

...mingnearly three dozen sensitive developmental and neurological testsdesigned to detect subtle effects of mercury exposure. Theanalysis included noting when the children learned to walk andtalk, measurements of reflexes, word recognition, and socialbehavior, and the best neuropsychological tests yet developed toe...

Genetically Engineered Mice Show Characteristic Signs Of Alzheimer's, Could Be Ideal Tool For Testing New Therapies

...t inhibit apoE4 orsimulate apoE3 to counteract the neurological effects of Alzheimer's. "The realtest of this model will come when we can test treatment strategies and see ifthey will work in humans," he said. In addition to Mucke and Raber, the researchers on the study, all of theGladstone Institutes, in...

Evidence Mounts Against Maintstream Dogma In Embryology, Could Shed New Light On Neurological Defects

... zebrafish mutants, may also shed light on certain neurological defects that affect humans as well as fish namely,holoprosencephaly. This syndrome, which can result in severe deformity and death, prevents the forebrain hemispheres from separating normally,in turn preventing the initial eye field from separating i...

Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia

...m tumors and may lead to newunderstanding of other neurological and immune disorders. The new research shows that the protein, called ATM for A-T, mutated, isa type of enzyme called a protein kinase that reacts to DNA damage by chemicallymodifying and triggering accumulation of a molecular "brake," or tum...

Scientists Find Gene For Severe Form Of Epilepsy

...eople worldwide, epilepsy is one of themost common neurological disorders," explains Scherer, a scientist in theGe...ce and ischaracterized by seizures and progressive neurological degeneration. Deathusually occurs within a decade of the first symptoms." While Lafora disease is ra...

Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness

...rking to apply "ribozyme rescue" to heart disease, neurological disorders and viral diseases. "UF's work is a great example of how fundamental research, whose goal is to understand basic cellular processes, can lead to important advances that have a direct impact on human health," said John Burke, a professor of...

Relapses Prevented In Mouse Model Of Multiple Sclerosis: Research Aimed At Treating Relapses In Human MS

... issue of the Journal of Immunology. MS, a neurological disorder, affects 300,000 or more young adults in theUnited States. Many with the disease suffer from relapses after the initialonset of such symptoms as numbness and paralysis. Trying to remedy theserelapses is the research focus of Rostami and his ...

Rare Brain Mapping Procedure Provides Unique Picture Of Two Areas Concerned With Language Processing and Production

...udedGeorge Ojemann and Carl Dodrill, professors of neurological surgery; JamesBrinkley, research associate professor of biological structure; Susan McBurney,doctoral student in linguistics, and Kevin Hinshaw, doctoral student in computerscience and engineering....

Fetal Surgery For Spina Bifida Still Under Investigation At VUMC

...earchers came up with the 'two hit' hypothesis for neurological deficits withspina bifida," Bruner said. The first damage, or hit, to the spinal cord comes from the fact that the fetushas spina bifida and the spinal cord is developing in an abnormal fashion. Thesecond hit results from the prolonged exposure of t...

Duke Study Finds More Genes May Be Affected By Toxic Cadmium

...n linked to kidneydamage, respiratory diseases and neurological disorders. It is also known tocause various cancers in rodents, and population studies suggest it causes humantumors, too. Previous studies, some of them led by Freedman, had identified less than15 genes that respond to cadmium exposure by tr...

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