Treatment in mice proves effective against Duchenne muscular dystrophy
...most prevalent of the muscular dystrophy family of neuromuscular diseases. Patients with Becker, limb girdle and other muscular dystrophies also might benefit from the approach used in the study, Kaufman said. "The potential exists to enhance the expression of the endogenous normal alpha 7 integrin gene, or exten...Influence of gender on upper airway structure and function during obstructive sleep apnea
... in the necks of men compared with women. Second, neuromuscular factors are the dominant factors when the upper airway is challenged and these factors are not different between men and women. The similarity in Pcrit and the similarity in genioglossus response to inspiratory loading support this postulate. The aut...Early detection device for exposure to chemical warfare agents being developed
...ody and brain involved in learning, memory and the neuromuscular system, Dr. Buccafusco said. In fact, muscle contr...ate and breakdown rate for acetylcholine is in the neuromuscular system. As soon as the monkeys show the cold-like signs of increased salivation and eye secretion, t...A 2,000 year-old technique may hold the key to acupuncture's therapeutic effect
...te. Exclusion criteria were a history of diabetes, neuromuscular disease, bleeding disorder, collagen vascular disease, acute or chronic corticosteroid therapy, and extensive scarring or dermatological abnormalities in the areas tested. Volunteers taking anti-inflammatory or antihistamine medications were asked to...'Wishful thinking' gene regulates neural development
... wishful thinking ( wit ), by studying the larval neuromuscular junction (NMJ) in the fruit fly Drosophila . The ...here is some kind of signaling that happens at the neuromuscular junction that coordinates the muscle growth with synapse growth," said O'Connor, who is at the Unive...Putting microRNAs in their place
...muscular atrophy, the second most common childhood neuromuscular disorder. This finding of shared components between the SMN complex and the miRNP suggests a possible link between the pathway of miRNA activity and the progression of this common disease....For the longest distance runner, that tired feeling may not be due to central fatigue
...cise, few studies have examined the alterations of neuromuscular function after a grueling physical endeavor. Now,...ntists set out to examine such changes in runners' neuromuscular function after a 65 kilometer (40 mile) race, which is approximately equal to the distance between t...Can we enlist substitute genes to fight muscular dystrophy
...le for Duchennes muscular dystrophy (DMD), a fatal neuromuscular disease. In the May 15th issue of the Journal of N...strophin and utrophin perform similar tasks at the neuromuscular junction where nerve cells meet muscle tissue and studies have shown that utrophin over-production...Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
... muscle. Researchers also observed the presence of neuromuscular junctions, indicating that the muscle was supplied with nerves giving the muscle the ability to become functional tissue. These findings indicate that the use of MDCs may prove to be a very promising new therapy in the treatment of urinary incontinen...Scientists identify a new kind of genetic problem in muscular dystrophy
...ewly identified genetic problem underlies a common neuromuscular disorder called facioscapulohumeral muscular dystr...e disease. FSHD is the third most common inherited neuromuscular disorder, affecting one in every 20,000 people (only Duchenne muscular dystrophy and myotonic dystro...NY panel to discuss bioterrorism and medical issues
...ngineering advances in solving musculoskeletal and neuromuscular diseases. -30-...Drug combination increases life span of mice with ALS
...rk in patients." A steadily progressive and fatal neuromuscular disease, ALS erodes a person's nervous system, eve...lth Research (CIHR), has funded over $9 million of neuromuscular research since 2000. "This is very exciting news for the ALS community," says Helene Vassos, interim...New cause identified for incurable muscle condition
...ent in this study exhibited normal function at the neuromuscular junction, but once the signal traveled to the muscle, it failed to excite, or spread over, the length of the muscle. Genetic analysis revealed a new mutation in the muscle's sodium channel. Dr. Cannon's team identified a defect in the gates that open...Grant strengthens research arm of Penn State Hershey Medical Center's ALS Clinic
...ll identify patients with ALS and those with other neuromuscular diseases and look for the prevalence of the mutated form of the Hfe gene in the two groups. A mutation in the Hfe gene has been linked with a condition called hemachromatosis, which causes too much iron to accumulate in the tissues. People can be car...Gene therapy prolongs survival, slows disease progression in ALS mice
...also known as Lou Gehrig's disease. ALS is a fatal neuromuscular disease characterized by the degeneration of spinal and brainstem motor neurons, leading to atrophy of limb, head-and-neck, and respiratory muscles. Plans for the first ALS patient trial utilizing this approach are underway. Fred H. Gage, Brian Kaspa......led successfully in the treatment of neurological, neuromuscular and atherosclerotic disease. "We know that creatine plays a pivotal role in maintaining energy levels in the brain," says Dr. Rae. "So it was a reasonable hypothesis that supplementing a diet with creatine could assist brain function." The experiment...USC awarded multi-million dollar engineering research center by National Science Foundation
...g who heads a research program that has produced a neuromuscular implant called the BION(tm), will be the center's ...ing clinical trials of the BION(tm), an injectable neuromuscular stimulator. The BION - short for bionic neuron - is the length of two grains of rice. During t...NSF awards $68 million for new engineering centers
...ntly incurable diseases such as blindness, loss of neuromuscular control, paralysis, and the loss of cognitive function. The researchers will focus on mixed signal systems on a chip, power and data management, intelligent analog circuits, interface technology at the nano- and micro-scales to integrate microelectr...Small-molecule inhibitors of botulinum neurotoxin identified
...d cleaves, or cuts, specific proteins that control neuromuscular function. Cleavage of these proteins effectively blocks the release of neurotransmitters that cause the muscle contractions necessary for respiration. The result is a flaccid paralysis that ultimately leads to suffocation and death. Because botu......cho of silence: Silent mutations, RNA splicing and neuromuscular diseases" makes the science of this paper understandable. Levodopa addiction in nonparkinsonian patients Patients with Parkinson's disease (PD) often crave their next dose of levodopa. This craving has been attributed to the severity of PD symptoms...