Easily paralyzed flies provide clues to neurodegeneration
...pilepsy, muscular dystrophies and a range of other neuromuscular disorders. What's more, the flies promise a window to identifying genes - many of which have human counterparts - involved in neural function and disease. "Because the molecular mechanisms of neural function are highly conserved, whateve...JCI Table of Contents, January 15 2004
...cx3 in skeletal muscle physiology. TITLE: Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3 AUTHOR CONTACT: Sophie Sokolow Universit Libre de Bruxelles, Gosselies, Belgium. Phone: 32-2-650-98-24 Fax: 32-2-650-98-20 E-mail: ssokolow@ulb.ac.be View the PDF of...Gene predisposes infants to neurologic injury after heart surgery
...variants in the Mental Development Index (MDI), in neuromuscular examinations or in head circumference. However, added Dr. Gaynor, further evaluation of a larger sample of eligible patients confirmed the lower scores on the PDI, and also found a significant effect of APOE ε2 in predicting worse outcomes i...Secondary complications and restoration of function in SCI
... clinical use of electrical stimulation. Portable neuromuscular stimulator aids exercise and mobility for individu...ulation. The design and development of a portable, neuromuscular stimulator for use by individuals with paraplegia is described in this article. Potential uses of th...Gene mutation found for a form of juvenile-onset motor neuron disease
...as mistakenly thought to carry a different kind of neuromuscular disorder. "This study shows the power of large families to contribute to research critical for understanding the genetics of disease," Chance added. Scientists from several countries worked together to locate and study families with this form of ALS...Sodium channel gene mutation identified in case of familial epilepsy
...new genes in other neurological disorders, such as neuromuscular diseases, ataxia, sleep disorders and dystonia. "By identifying genes and mutations in these specific neurological disorders, we should be able to give more precise care to our patients, as well as give them better answers about their disorders," s...Study of ProCord for neurologically complete spinal cord injury
..., brain injury, stroke, amputation and orthopedic, neuromuscular and musculoskeletal disorders. In fact, Kessler is one of only 16 centers in the country to be designated as a model system for the treatment and research of spinal cord injury. With four hospital centers located in West Orange, East Orange, Saddle ...Scientists discover key step in the development of nerve cells controlling autonomic functions
... and treatment of epilepsy, multiple sclerosis and neuromuscular disorders....It's a no-brainer: Prepare for West Nile virus
...ngly, encephalitis was an apparent risk factor for neuromuscular complications; it's very rare for this brain infec... encephalitis and, of those, 82 per cent developed neuromuscular dysfunction within days. The Toronto experience was similar to earlier experiences of WNV infection...Newly discovered protein may be key to muscular dystrophy
...mammals could lead to useful therapeutics to treat neuromuscular diseases as well as disorders of the central nervo... maintains the neurotransmitter transporter at the neuromuscular synapse. In this location, the transporter is available to clear excess acetylcholine. Further...Heartless worms hold clues to cardiac arrhythmias, sudden death
...on of HERG. The mutation, unc-103, causes profound neuromuscular defects, including a pharyngeal pumping defect that Petersen noticed as she learned to work with the worms. "I remember the first time I saw it (the pumping defect)," she said. "It looked just like a cardiac arrhythmia." Whereas the normal worm phar...Common cold virus can cause polio in mice when injected into muscles
...e muscle where axons physically attach is called a neuromuscular junction. These junctions likely served as the cold virus' portal of entry into the nervous system. "We gave the coxsackievirus a distinct advantage by injecting it directly into muscle, where it had direct access to the kinds of nerve cells polio no...Venn diagram tactics to vet complex disease
A whole range of human muscular and neuromuscular diseases are caused by mutations in the mitochondrial respiratory chain/oxidative phosphorylation system. The problem is that there are about 120 genes involved in this system, some that are found in the mitochondria, and thus inherited through the ...JCI table of contents September 15, 2004
...mplex Disease A whole range of human muscular and neuromuscular diseases, are caused by mutations in the mitochondrial respiratory chain/oxidative phosphorylation system. The problem is that there are about 120 genes involved in this system, some that are found in the mitochondria, and thus inherited through the......write that code while measuring motion, forces and neuromuscular signals. They will work closely with two mathematicians - Philip Holmes, professor of mechanical and aerospace engineering at Princeton University, and John Guckenheimer, professor of mathematics and theoretical and applied mechanics at Cornell Unive...