Brain Protein "Rescues" Neurons From Atrophy
...phering the intercellular chemical "language" that neurotrophins use in fostering brain cell growth. Graduate stude...ious studies at Duke and elsewhere have shown that neurotrophins generally increase the survival and growth of brain cells, or neurons. However, it was not known whe......ighbouring microglial cells. The data suggest that neurotrophins acting via their p75 receptor are involved in this process, demonstrating an immunological function for these signalling molecules. MHC class II antigens are dimeric glycoproteins, which are loaded with pathoge...Learning is growing: scientists investigate the links between memory and brain development
...mory continue a string of exciting indicationsthat neurotrophins are also important for strengthening synapses in t...Poo(University of California, San Diego) show that neurotrophins have more effecton weak synapses than strong ones. Measuring signal strength between pairs ofnerve ...Errant nerve cells risk a clockwork death
... for limited life-giving chemical signals known as neurotrophins whenthey reach their final target." Competition fo...model of axon guidance, axons receive support from neurotrophins asthey pass through the region of the intermediate target, rather than when theystop at the target, ...Health of normal synapses seen to depend on neurotrophin signaling
... family of compounds calledneurotrophins. Although neurotrophins are known to be critical during development, the c...d in development and in adulthood, andsuggest that neurotrophins may protect synapses from atrophy in aging and patients with certain neuromuscular diseases orinjuri...Sleep in early life may play crucial role in brain development
...g non-REM sleep. "Right now we don't know if these neurotrophins are released during sleep. We do know that other g...released during sleep and we also known that these neurotrophins play a role in learning and making the synapses of the brain stronger and weaker," says co-author Na...Controlled nerve growth factor aids brain cell transplant
...uitization. But we can't just flood the body with neurotrophins because of the adverse side effects. These are potent molecules that influence other cell functions, besides survival and axonal growth, and they can promote inappropriate growth among other tissue. We needed to create a local delivery system to en......al. Particularly important was their finding that neurotrophins had this effect by activating a molecule called cyclic AMP (cAMP). The members of the team then showed that if the levels of cAMP in neurons was increased, this was sufficient to overcome the inhibitors in myelin and to encourage nerve regeneration i...Delayed treatment of spinal cord injury may improve recovery
...imals have shown that fetal tissue transplants and neurotrophins can improve regrowth of injured neurons in the adu... delayed transplant plus treatment with one of the neurotrophins could partially support their weight on their rear legs and had more coordination between the front ...Brain-derived neurotrophic factor (BDNF): From maternal deprivation to manic depressive illness
...chromosome 11 and belongs to a family of so-called neurotrophins - nerve chemicals that promote the growth and survival of neurons....