Tag: "neutralize" at biology news

Molecular 'stop signs' may hold secret of nerve regeneration

...in or spinal cord has been damaged, the goal is to neutralize those inhibitors so that the long tentacles of nerve cells, the axons, might reestablish their broken connections, says Schnaar. The research team reports identifying brain chemicals that are involved in the ability of one of the inhibitors to preven...

First drug developed for widespread use against botulism

...tibodies to determine whether the antibodies could neutralize toxin in mice....

Promising multi-strain HIV vaccine candidate emerges

...n a consistent ability to generate antibodies that neutralize a wide range of HIV-1 isolates," says Dr. Devico, assistant professor, IHV. "The preliminary findings indicate the gp120-CD4 complex might serve as a useful model for HIV vaccine development," he adds. Long the hope of AIDS researchers, it now appea...

Understanding acetaminophen poisoning

...ses another chemical called glutathione to quickly neutralize NAPQI. "The problem occurs when you run out of glutathione," said Moore. An overdose of acetaminophen can cause depletion of glutathione and land a person in the hospital. "Acetaminophen toxicity is the number one cause of hospital admission fo...

Code-breaking insects steal plants' defensive signals, enabling counterattack

... proteins similar to those in the human liver that neutralize toxins. "Jasmonic acid to the plant is like a Paul Revere running around shouting, "The British are coming, the British are coming," getting everybody in Boston to grab guns and call for reinforcements," Berenbaum said. "With this early warning sign...

Tips from the Journals of the American Society for Microbiology

...have developed human antibodies that recognize and neutralize the Shiga toxin. These antibodies not only neutralized over 85% of the Shiga toxin in cell cultures, but also significantly increased survival when administered to experimentally infected mice. "Presently, no effective treatment or prophylaxis for H...

INEEL researchers discover that concrete degrades nerve agent and can predict rate of decay

...basic pH (10 or higher), and this pH enables it to neutralize the VX nerve agent. At a comfortable 24 degrees Celsius (75.2 degrees Fahrenheit), VX will degrade to 1 percent of its original concentration within 15 hours, and dwindle to a mere 10-millionth of original concentration within 50 hours. Other factors...

Critical therapeutics is awarded U.S. patents for methods to diagnose and treat inflammatory disease

... treat the inflammatory illness. These antibodies neutralize the pro-inflammatory effect of HMGB1. U.S. patent number 6,303,321 B1, "Methods of Diagnosing Sepsis," provides for a method to diagnose the disease and to predict its severity by measuring the concentration of HMGB1 in the serum. The Societ...

Bodys own antibodies may drive new strains of HIV

...to rapidly mutate and escape the body's efforts to neutralize or destroy it. In fact, up to dozens of strains can develop within the same person. Also, HIV infects and disables the very immune cells, helper T cells, which are supposed to mobilize the immune system against the virus. Richman's study is the first...

UW researchers find second anthrax toxin receptor

...one part toxin, we found that we could effectively neutralize the toxin. Much more of the ATR decoy was required to be effective." Young said his team now is trying to understand why the new decoy works better. "We are trying to further improve its function. Our hope is that an improved form of the decoy coul...

Water quality in Adirondack lakes responding to acid rain regulations

... Capacity (ANC) the ability of a body of water to neutralize acid. ANC is an important measurement, according to Driscoll. "If it's a positive value ... that's a good thing. But if you have a negative value, you've got more acids than bases." A body of water with a negative ANC may be "fishless." In fact, any...

Binding studies suggest drug development strategy for lupus

...nd to get into the body where it could bind to and neutralize Tall-1." The Tall-1 molecule is an important regulator of the immune system. It spurs B cells to mature and produce antibodies, one of the body's major defense mechanisms. Mice engineered to make too much Tall-1 develop lupus-like symptoms. People wi...

Structure of HIV-neutralizing antibody solved

...olved the structure of an antibody that is able to neutralize HIV, the virus that causes AIDS. Their work is described in the June 27 issue of Science. The antibody, called 2G12, was isolated about a decade ago from one of the rare HIV-positive individuals whose body is able to successfully combat the virus. Sc...

Towards an AIDS vaccine: unusual antibody that targets HIV described by scientists at TSRI

... against HIV, but they are almost always unable to neutralize the virus. Much of the viral surface is coated wit... some people have produced antibodies that broadly neutralize HIV. One such antibody, called 2G12, was isolated from an HIV-positive individual about a decade ago...

Researchers identify clotting protein which causes hepatitis B

...of Toronto. "Antibodies are now being generated to neutralize fgl2 activity which we hope will be useful in treating patients with viral hepatitis, and may be of value to patients with SARS. We are now examining patients with SARS for fgl2 activity and the possible use of neutralizing antibodies for their treat...

Toxic protein could explain Alzheimer's and lead to breakthroughs

...pathology. If we can develop drugs that target and neutralize these neurotoxins, it might be possible to not onl...e antibodies appear to restore memory because they neutralize ADDLs, which Klein's group has found in mouse models with Alzheimer's as well as in human brains wit...

Researchers identify botox receptor

...ber 29, Dong has developed decoys that effectively neutralize one type of the neurotoxin. Specifically, he created fragments of the syt II protein that contain the toxin's binding site. In collaboration with Goodnough and Johnson, these fragments, along with gangliosides, were injected into the bloodstream of ...

Taking aim at bioterrorism: UH professor gets HHS funding to battle anthrax

... fundamental research about anthrax and methods to neutralize its impact. "By understanding the mechanisms of early infection, we hope to generate novel strategies for the development of therapeutics and vaccines to treat and prevent cases of inhalation anthrax," Blanke said. The Blanke Lab will work closely...

Hebrew University, German and British researchers develop means to help stress sufferers

...ed in developing an "antisense" agent that acts to neutralize the process whereby the modified protein is produced, thereby preventing the "extreme" reaction associated with traumatic memory-inducing stimuli. The researchers from the Hebrew University involved in the project are Prof. Hermona Soreq, who heads...

Story tips from the Department of Energys Oak Ridge National Laboratory, January 2004

.... Researchers also believe the lamp can be used to neutralize chemical warfare agents on, for example, buildings, tanks or barracks. The process would involve spraying the area with a low-volume proprietary mixture of harmless chemicals and then zapping the area with the lamp. The light activates the mixture, w...

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