Study demonstrates altered angiogenic proteins in preeclampsia patients
...d be through administration of drug therapies that neutralize the effects of sFlt1, explains coinvestigator Vikas P. Sukhatme, MD, PhD, Chief of the Renal Division at BIDMC and Victor Aresty Professor of Medicine at HMS. "One such approach might be to administer VEGF or PGF," he adds. In a related study appear...Exposure to low-level magnetic fields causes DNA damage in rat brain cells, researchers find
...esearchers gave some of the rats drugs that either neutralize free radicals or decrease free iron before exposing the animals to the magnetic field. The treatments supported the hypothesis, effectively blocking the effects of the fields and protecting the rats' brain cell DNA from damage. One significa...Insights gained from molecular modeling may lead to better insecticides
...ack swallowtail butterflies (Papilio polyxenes) to neutralize insecticides and plant defense allelochemicals that target insect herbivores, researchers focused on the insects primary detoxifying cytochrome P450 enzymes. The study was published online Monday (Feb. 23) in advance of regular publicatio...Drugs limit deadly side effects of graft-versus-host disease
.... Since then, they have been searching for ways to neutralize cytokines or block their production. Their current work with HDAC inhibitors is an extension of this earlier research. "No one has looked at this class of drugs in a post-bone-marrow-transplant setting before, but two other groups have found similar ...VaxGen reports Phase I clinical trial results of anthrax vaccine candidate
...urified protein designed to induce antibodies that neutralize anthrax toxins.) A second Phase II trial, scheduled for later this year, is designed to determine the optimal dosing schedule of rPA102 for use before and after exposure to anthrax. "We look forward to advancing the development of rPA102 and to the ...Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
...create a vaccine that generates antibodies able to neutralize HIV," says Hildegund C.J. Ertl, M.D., professor and immunology program leader at Wistar and senior author on the report published in the July issue of the Journal of Virology. "The next best thing may be to develop a vaccine that stimulates the produ...Impact of Earth's rising atmospheric carbon dioxide found in world oceans
...ing calcium carbonate shells also partially act to neutralize CO 2 , thus allowing the ocean to take up more carbon dioxide from the atmosphere. However, the effects of decreased calcification in microscopic algae and animals could alter marine food webs and, combined with other changes in salinity, temperatur...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
... by the gp120 glycoprotein of HIV-1 and is able to neutralize a broad-range of HIV-1 isolates. It is, therefore, important to examine whether naturally occurring SARS-CoV expresses the auto-immunogenic reactivities that are found in the monkey produced viruses. During a potential SARS epidemic spread, the vir...Researchers find clues about how antibodies specialize
... antibodies proteins that recognize, bind to, and neutralize viruses and other harmful pathogens. Since there is a huge diversity of pathogens in the environment more than our genomes could possibly anticipate and encode for -- the antibody response has to be very fluid and adaptable. The human immune system ...Small, Smac-like molecule encourages death of cancer cells
... likely need fewer of our Smac mimics than IAPs to neutralize IAP effects, because once the cell death program gets started, it generates more Smac-like activity as it proceeds." Dr. Wang said, "If this turns out to be true, it's remarkable, because then you would only need a tiny amount to have a dramatic imp...'Defensive' action by influenza viruses demonstrated by Hebrew university researcher
...w it, they've found a way to defend themselves and neutralize the anti-viral treatment. How, exactly, do the viruses do it? In an article published as the cover story in a recent issue of the journal Proteins, a Hebrew University of Jerusalem researcher, Prof. Isaiah (Shy) T. Arkin, has revealed just how influ...