Researchers identify protein promoting vascular tumor growth
...crophages by observing tumor responses to an MCP-1 neutralizing antibody in mice when varying levels of macrophages were present. "Our observations specifically link MCP-1 and macrophages as key contributors to the development of these tumors. MCP-1's essential role in supporting proliferation of HEs indic...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...ther illustrated in additional experiments where a neutralizing anti-TRAIL antibody was injected into the mice following the LPS challenge. The result was tumor growth. In their summary, the researchers said that since TNFα does not make a major contribution to tumor killi...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...ol extracts, the researchers reported. As shown by neutralizing antibodies, migration was primarily dependent on IL-8, and less on bFGF or VEGF. Finally, IBD-derived extracts induced a potent angiogenic response in the corneal assay compared to control-derived extracts, they noted. Conclusion The results provid...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
...ized the carbohydrate binding activity of SARS-CoV neutralizing antibodies elicited by an inactivated SARS viral vaccine and found: 1.) An undesired autoantibody reactivity is present in SARS-CoV neutralization antibodies 2.) the autoimmune reactivity is directed toward the complex carbohydrate of an abundant hu...Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
...are exposed to adenoviruses in childhood and carry neutralizing antibodies against the viruses that would interfere with the effectiveness of any vaccine based on them. About 45 percent of adults in the United States, for example, have pre-existing immunity to the most prevalent strains of adenovirus, and similar...RSV can increase the risk of asthma, UT Southwestern researchers find
...ed study, also in mice, suggests that a medication neutralizing the virus could decrease children's chances of dev...studies have found that treatment with an anti-RSV neutralizing antibody significantly reduced hospitalization rates in high-risk infants. UT Southwestern researche...Antioxidants during pregnancy may help prevent birth defects tied to alcohol
... Antioxidants protect key cellular components by neutralizing the damaging effects of free radicals, natural byproducts of cell metabolism. Free radicals form when oxygen is metabolized, or burned off, by the body. They travel through cells, disrupting the structure of other molecules, causing cellular damage. ...Friendly bacteria block HIV infection
...e-binding protein particles into its surroundings, neutralizing HIV by binding to its sugar coating. The other Lactobacillus strain also neutralized HIV particles but required direct contact with the virus because its mannose-binding proteins reside on its surface. That requirement made this strain less effecti...JCI table of contents, 2 April 2004
...ents develop antibodies to these clotting factors, neutralizing treatment. An alternative treatment is the infusion of a recombinant Factor VII (FVII), a procoagulant reaction activator that is independent of FVIII and FIX. But this treatment is extremely costly and the recombinant FVII has a very short half-lif...Nanotechnology highlights from the ACS national meeting in Anaheim, Calif., March 28-April 1
... a matter of weeks. The particles are effective in neutralizing a wide variety of environmental contaminants, including PCBs, DDT, trichloroethylene (TCE) and perchlorate. The particles, which will soon be mass produced, have already been used to effectively clean up several contaminated industrial sites in the U...Study suggests possible way to repair damaged nerve cells
...re able to prevent the death of damaged neurons by neutralizing a specific protein the injured cells secreted. Neurons carry messages from the brain to the spinal cord and the rest of the body. Damaged neurons are rendered useless by the physical interaction of two cellular proteins proNGF and p75, the resear...DNA vaccine protects against anthrax
...ith PA induces antibodies that are more capable of neutralizing toxin and conferring protection," says Bell. ...JCI table of contents, March 1 2004
...ally, this fibrogenic activity could be blocked by neutralizing anti TGF-beta1 antibodies confirming that TGF-beta1 is directly involved in bone marrow fibrosis in HCL. The report also suggests that the levels of circulating TGF-beta1 should be considered as a non-invasive indicator for the ongoing fibrogenic pro...Anti-interferon beta antibodies in MS care: A consensus
...enters (CMSC) announced today that the presence of neutralizing antibodies (NAbs) has a significant effect on inte...terferon beta (Avonex, Betaseron or Rebif) develop neutralizing antibodies (NAbs), which limit or prevent the medication from having its full therapeutic effect. A...Lunch workshop at the American Association for the Advancement of Science (AAAS) Annual Meeting
...ed neurology experts who will explore the issue of neutralizing antibodies (NAbs). The discussion will focus on: Challenges in multiple sclerosis care and research The model of the Consortium of Multiple Sclerosis Centers (CMSC) in meeting these challenges Previous consensus conferences utilizing this model ...Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model
... animals, but not from the controls, showed strong neutralizing capacity against SARS-CoV. "From a scientific perspective, several points are important. We obtained the recombinant vaccine by engineering a common cold virus to express the SARS coronavirus antigens. This is a successful strategy that we are explo...Experimental hantavirus vaccine elicits strong antibody response in primates
...e (HPS), a highly lethal disease, elicits a strong neutralizing antibody response in laboratory animals--a respons...s. Vaccination with the plasmid elicited a potent neutralizing antibody response in rhesus macaques that were vaccinated a total of four times at three-week interv...New vaccines may address need to protect newborns in the developing world
...nt of the population in the U.S., for example, has neutralizing antibodies circulating in the blood able to impair any vaccine based on a common human adenovirus. In essence, many people would be prevented by their own immune systems from realizing the benefits of a vaccine based on a human adenovirus. For this r...Researchers identify botox receptor
...substance in the medical field and new methods for neutralizing it in the event of biological warfare. Botulinum neurotoxin - the toxin found in Botox - is the deadliest of all substances. Produced by different strains of a family of bacteria, it comes in seven forms, four of which are reported to cause the para...Psoriasis treatment based on Weizmann Institute Research passes phase II clinical trials
... with onercept later this year. The drug works by neutralizing a hormone called "tumor necrosis factor" (TNF), which is produced by the immune system in response to injury or infection. In various inflammatory diseases, TNF production becomes excessive, leading to the destruction of healthy tissue. In search for...