Researchers identify clotting protein which causes hepatitis B
...ith SARS for fgl2 activity and the possible use of neutralizing antibodies for their treatment." The work originally began in the laboratory of Dr. Gary Levy when his team isolated the protein molecule from the livers of corona virus-infected mice, and found that the molecule has unique and novel clotting aspects...Towards an AIDS vaccine: unusual antibody that targets HIV described by scientists at TSRI
...l be a component that elicits or induces effective neutralizing antibodies against HIV in the blood of the vaccina...e virus, making it unable to invade cells. Because neutralizing antibodies attack the virus before it enters cells, they could conceivably be used to prevent HIV in...Alzheimer's protein jams mitochondria of affected cells; resulting 'energy crisis' kills neurons
...s could be developed to fix this domain, either by neutralizing its charge or folding it more tightly."...Researchers discover strategy that shields HIV from destruction
...ism of virus escape," he said. "We found that the neutralizing epitopes on the virus did not change, but instead ...changes in glycan molecules prevent the binding of neutralizing antibodies to the virus surface through steric inhibition, thereby enabling the virus to avoid antib...Bodys own antibodies may drive new strains of HIV
...antibody response and continue to replicate. "The neutralizing antibodies are exerting a very strong selective pr... from previous months' samples were ineffective in neutralizing new virus from the same patient. "The bad news is that the virus is always staying a step ahead, an...Causation between white blood cells and lung disorders confirmed
...hils alone. In an attempt to avoid the effects of neutralizing IL-5, eosinophils were removed in the lungs of allergen-sensitized/challenged mice through using CCR3, a chemokine receptor whose principal ligands (i.e., eotaxin -1 and -2) are potent chemoattractants, displaying a unique specificity for eosinophils...Cell density determines extent of damage caused by cigarette smoke exposure
...uot from each lot of collagen solution. Anti-TGF- neutralizing antibody, which showed greater than two percent cross-reactivity with human TGF-2 and TGF-3 and did not cross-react with other growth factors, and anti-immunoglobulin were used. CSE was obtained by combusting one cigarette without filter with a mod...Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
...so that more than 45 percent of the population has neutralizing antibodies circulating in the blood able to impair any vaccine based on a common human adenovirus. But the new chimpanzee adenovirus vaccine possesses the immunological strengths of a human adenovirus vaccine without the drawback of pre-existing immu...Microscience to license vaccine delivery technology
...nstrained HIV-1 env immunogens that elicit broadly neutralizing antibodies, was recently published [Vaccine 20(15):1968-1974, 2002]. Microscience will pay UMBI an upfront license fee plus milestones and royalties if the products based on the technology are successful. The parties have agreed not to disclose fu...First drug developed for widespread use against botulism
...eadly agents where antibody has been shown to have neutralizing activity, such as anthrax, smallpox, plague or hemorrhagic fever viruses, the scientists conclude. UCSF has applied for a patent on the drug. The paper reports on three antibodies, one fully human and two that derive from both mice and humans. Althou...Antioxidant protects islet cells used in transplants for diabetes
...et cells survive and improve transplant success by neutralizing the free radicals. The researchers used two synthetic antioxidants developed several years earlier by Dr. James Crapo, M.D., Chairman of the Department of Medicine at National Jewish, and his colleagues. The antioxidants, dubbed AEOL10113 and AEOL101...Bone marrow transplants may be improved due to the uncovering of a key mechanism
.... Inhibition of SDF-1 and CXCR4 interactions with neutralizing antibodies blocked stem cell mobilization. The findings may lead to improved collection of stem cells for clinical transplantations. They also shed new light on neutropenia, resulting from a genetic defect in the elastase enzyme, which the group fou...A new weapon to disable bacteria discovered
...a new generation of antibiotics that would rely on neutralizing the virulent proteins of disease-causing bacteria rather than indiscriminately killing microbes....Biologists track down central cause of lupus
...mal, healthy editing has the effect of covering or neutralizing certain DNA-attracting chemical units on the surface of the B cells. The re-editing in lupus mice re-exposes these chemical units, which have a strong chemical attraction for the phosphates that make up the backbone of all DNA. Weigert believes the p...New tool speeds study of mammalian protein function
...se then bind to matching strands of messenger RNA, neutralizing it and causing it to be degraded, thus interfering with protein synthesis. This effect of "knocking down" a gene's expression has broad practical applications--for example, to screen for protein function by seeing what happens to an organism when th...Chimpanzee virus may be key to better vaccines, study shows
...uch so that a third or more of the population have neutralizing antibodies circulating in the blood able to inactivate an adenoviral-based vaccine. Now, in a new proof-of-principle study in mice, researchers at The Wistar Institute and the University of Pennsylvania have shown that a vaccine based on a chimpanzee...Dartmouth researchers expose weakness of common parasite
...bility to replicate and survive in an animal host, neutralizing its virulence. Pyrimidines comprise two of the four DNA and RNA units (nucleobases). "If we destroyed the ability of the parasite to make its pyrimidines de novo, we had no idea whether we could add pyrimidines to the parasite growth medium and actua...UPenn Cancer Center offers prosate cancer prevention trial using selenium & vitamin E
...elenium and vitamin E are antioxidants, capable of neutralizing toxins known as free radicals, that might otherwise damage the genetic material of cells and possibly lead to cancer. These two naturally occurring nutrients were chosen for study because of the inadvertent results of two other large cancer preventio......ood vessels. Tumors were then targeted either with neutralizing monoclonal antibodies to VEGFR1 alone; with monoclonal antibodies to VEGFR2 alone; and to both. The targeting of either VEGFR1 or VEGFR2 partially blocked the growth of tumors. However, it was necessary to inhibit both VEGFR1 and VEGFR2 to completely......ortant part of such a vaccine will be an effective neutralizing antibody against HIV. Also called immunoglobins, these antibodies would be produced by the body's B cells after HIV enters the bloodstream. During such an immune response, the antibodies would circulate through the blood, and track down and kill the...