Embryonic skin cells committed at an early age
...s for the possible utilization of embryonic versus newborn or adult tissues as enriched sources of stem cell populations for cell replacement purposes. The intrinsically high commitment to differentiation is also likely to have important consequences for susceptibility to environmental and/or toxic agents an...Introduction of the 'Rett protein' in post-mitotic neurons rescues Rett Syndrome in mice
...sibility that neurons are functionally normal in a newborn child and that neural dysfunction manifests itself only later due to prolonged MeCP2 deficiency. If correct, therapeutic strategies aimed at preventing the onset of Rett symptoms could be initiated at birth. This project was funded by the Rett Syndro...Sickle cell sufferers living longer, dying less from their disease
...ers attribute the improved prognosis to widespread newborn screening that allows physicians to identify the d... All study participants were diagnosed through newborn screening and were all born in Texas on or after Nov. 1, 1983, when the state's screening program we...Study shows benefits to newborns from federal ban on insecticides
...rse association between the combined exposures and newborn birth length. However, when they looked at the relationship between insecticide exposures and fetal growth after January 2001, the exposure levels had been reduced substantially, and the impact on weight and length was no longer apparent. "This...Rb protein's role in retina development is key to understanding devastating eye cancer
...this mutation could be studied in both embryos and newborn mice. A progenitor cell is a "parent" cell that di...of the fact that the retina is still developing in newborn mice. The team used a virus to insert a gene for E1A--a protein that inactivates Rb--into newborn mi...Free, public events at the 2004 AAAS Annual Meeting
... News -- Thursday -- For her Presidential Lecture, newborn medicine pioneer and AAAS President Dr. Mary Ellen Avery, Children's Hospital Boston, will be joined by Dr. Richard Klausner, executive director for global health at the Gates Foundation. Dr. Avery will discuss the promise of scientific advances to a...2004 AAAS annual meeting spotlights world health, oceans and family science
...rand Ballroom ABC, 2nd Floor). Avery, a pioneer in newborn medicine, will describe the power of imagination and the promise of scientific discovery for alleviating human suffering, particularly for women and children. In Brazil, for example, some 130,000 children had lost at least one parent to AIDS by the e...JCI table of contents, February 2, 2004
...etry (MS/MS). This technique is now the choice for newborn screening for up to 40 metabolic disorders within both the USA and Europe. Through the use of mutagenesis in mice and screening of their offspring using MS/MS, a novel disorder similar to MSUD was discovered. The authors found elevated levels of bra...JCI table of contents, January 2, 2004
...the bile pigment bilirubin, is extremely common in newborn infants. In Western nations jaundice is most commonly treated with exposure to light (phototherapy), however a drug therapy would also be desirable. In the January 2 issue of the Journal of Clinical Investigation, David Moore and colleagues from Bayl...UT Southwestern researchers learn importance of insulin family signaling in male sex determination
...this problem, which has tremendous implications in newborn disorders." UT Southwestern researchers now want to determine if the insulin-signaling pathway is active in human gonad formation. It has been found only in mice, but there is a strong likelihood it exists in humans. "If the insulin-signaling pathway...Newborn screening for certain genetic disorders has benefits and some drawbacks
CHICAGO -- Expanded newborn screening for biochemical genetic disorders may le... to background information in the article, routine newborn screening is required practice for newborn care throughout the United States. Traditionally, testin......to take the baby, Alberta moved closer pushing the newborn into his mother's face until she took him. Variations on this sequence occurred several times in the first two days (Primates, DOI: 10.1007/s10329-003-0061-9). By the third and fourth day, Ione was holding the baby. Sometimes, Alberta would hold the...Diet may improve cognition, slow aging, and help protect against cosmic radiation
...nistered several environmental chemicals orally to newborn rats for two weeks, beginning one day after the animals' birth. The chemicals selected for the study were the sex hormone estradiol (E2); the synthetic estrogen diethylstilbesterol (DES); the plasticizer bisphenol A (BPA), which has been shown to lea...Alcohol's pharmacological properties, not smell or taste, reinforce its effects
...developing fetus/infant." Researchers examined 196 newborn rats during three experiments. The first experime...te or odor, is sufficiently reinforcing to allow a newborn rat to learn with only a single experience what predicted the alcohol," said Varlinskaya. "Since th...University of Pittsburgh named cooperative research center for muscular dystrophy
...nique population of muscle stem cells from healthy newborn mice to deliver dystrophin, a key protein for muscle function into animal models for DMD. Additionally, researchers led by Dr. Glorioso will be using herpesvirus vectors in functional genomics studies to discover and characterize factors that guide s...New vaccines may address need to protect newborns in the developing world
...f inducing protection against a dangerous virus in newborn mice. If the new vaccines are able to do the same ...rus. Following oral administration of the vaccine, newborn mice developed antibodies that protected them from subsequent exposure to the rabies virus. By exten...Small subset of cells has big role in controlling immunity, study finds
...fied at risk, Dr. Mellor said, referencing a large newborn screening program for type 1 diabetes under way by Dr. Jin-Xiong She, director of the MCG Center for Biotechnology and Genomic Medicine and Georgia Research Alliance Scholar in Genomic Medicine. "We have to use our immunology knowledge to protect pat...Stem cell defects are key to Hirschsprung's disease
...Hirschsprung's disease, which affects one in 5,000 newborn infants. Babies born with this disease don't develop ganglion cells specialized nerve cells in the large intestine, which trigger contractions to push feces through the colon and out the rectum. The result is chronic constipation and intestinal obs...From studies of a rare human mutation to new approaches to herbicides or antibiotics
...d. A September 1999 report of a routine screen of newborn infants for metabolic defects identified a new mutation in PBGS, termed F12L, that causes the enzyme to lose activity, as reported by Shigeru Sassa, M.D., Ph.D., of Rockefeller University and co-authors in the British Journal of Haematology. Detailed......mined the effect of intracerebroventricular NPY on newborn body weight gain and adult food intake and body we...y weight gain pattern was observed in males. The newborn animals that received NPY demonstrated hyperinsulinemia at three days of age, with no change in gluc...