New analysis gives cancer patients personalized prognosis
...ding traditional clinical variables, such as lymph node and estrogen receptor status, and multiple, complex patterns of gene activity, or "genetic fingerprints," of a patient's tumor. They integrated these data to formulate unique predictions about individual patients' recurrence risk. While the Duke stud...UCSD finds genetic time bomb in heart that leads to heart failure in some patients
..., in particular, the heart's atrioventricular (AV) node (which normally conducts electrical impulses betwe...herited atrial septal defects, causing advanced AV node malfunction, and in some of the family, unexpected death. Heart tissue samples from affected family...Other highlights in the May 5 JNCI
...hat allows researchers to visualize sentinel lymph node drainage in mice may be able to detect lymph node metastases from breast cancer. Lymph node metastases are an indicator of prognosis in breast cancer ...Gene expression profiling may predict head, neck cancer recurrence
...ar biology that differentiated patients with lymph node metastasis from those without metastasis. "We can see a signature in tumor cells that indicate they are likely to metastasize and the converse, that they are less likely to do so," Perou said. "This is preliminary data. It must go through rigorous te...Other Highlights in the June 2 JNCI
... explored how the revision affected sentinel lymph node positivity, the false-negative rate, and the overall accuracy of the sentinel lymph node biopsy in a cohort of 205 breast cancer patients undergoing breast cancer surgery that included sent...Susceptibility of mice to mousepox offers promise of smallpox protection
...response. Conversely, they found IL-2 in the lymph node but not in the spleen. The reasons why this happens are still unclear, said Karupiah, but understanding them may help researchers figure out what constitutes an effective immune response. The mousepox model has proven a useful tool for studying small...Gene therapy alternative to calcium channel blockers
...oviral transfer of the Gem gene was made to the AV node of heart muscle, which is where the heartbeat originates. Calcium is vital to maintaining good health, as it is involved in many everyday cellular processes, including gene regulation, memory and cell death. However, excessive levels of calcium can ...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
... a pathologist looking for changes in normal lymph node architecture and cell characteristics through a series of tests, such as blood tests, x-rays, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and bone marrow biopsy. "There are many types and subtypes of lymphoma, some of which ......rvey (USGS) to set up a Coral Database (CoralData) node for the southeast region of the U.S. The team hopes to extend this database to include a national database and ultimately an international coral database. CoralData aims to increase understanding of the distribution and abundance of co...