Tag: "nonviral" at biology news
Steroid-coated DNA represents new approach to gene delivery
... basic approaches to delivering therapeutic genes: nonviral
and viral. Injecting a subject with pure DNA is possible, but a DNA molecule, by itself, has inherent trouble in entering cells. Viral carriers can serve as delivery vehicles for DNA, literally infecting cells with new genes. Both methods, howeve...
New gene therapy shows promise for hemophiliacs
...nd cultured in the lab and then transfected with a nonviral
plasmid vector carrying the gene for human coagulation factor VIII. After allowing them to further expand, those stably transfected BOECs are then given back to the patient, where they seek out the bone marrow and the spleen and start to divide. "Th...
Study finds nonviral gene therapy for severe hemophilia a is safe with early signs of benefit
...d Journal of Medicine. The study, which utilized a nonviral
gene therapy system developed by Transkaryotic The...ector gene therapy are essentially obviated by the nonviral
method used here to introduce the factor VIII gene into the cells, by modifying the cells outside th...
Researchers overcome hurdle of transporting large amounts of DNA to the nucleus
using nonviral vectors
...ssueof Nature Biotechnology. "We're looking for nonviral
routes to introduce DNA to cells that are notrapidly dividing," says senior author Scott Diamond, PhD, associate professor ofchemical engineering at Penn. "Most gene therapies involve adenoviruses oradeno-associated viruses, but they're expensive to ...
Researchers Track Path Of Safer Gene Delivery Method
...ybring DNA to a patient's cells by way of a safer, nonviral
gene therapy method. Poly(ethylenimine) (P...e response. Researchers have wanted to find safer, nonviral
agents to gainaccess to cells. Both viral methods and nonviral
methods using liposomes, whic...
UI Researchers Find Potential Gene Therapy For Cystic Fibrosis
...s involve inserting the CFTR gene into a vector--a nonviral
carrier or anadenovirus--to facilitate transferrin...ic fibrosis," McCray said. A retrovirus, unlike a nonviral
carrier or an adenovirus, can integrate into thehost DNA. "A retrovirus has the advantage of permane...
New Gene Therapy Technique Results In 60 Percent Tumor Regression Rate
... California-basedbiotechnology company have used a nonviral
gene expression system invented hereseveral years ...d other reasons, scientists have beenlooking for a nonviral
delivery system to use with gene therapy treatments, saysXiao Chen, lead author of the study and an ...
Scientists Invent Faster Gene Function Identification System
...niques, which can take months to years. By using a nonviral
gene expressionsystem to inhibit the expression of specific genes in zebrafish, the scientistsisolated gene function without destroying the gene, says Thomas E. Wagner,distinguished professor of molecular and cellular biology at Ohio University anda ...
New Nonviral Gene Therapy System Could Help Fight Cancer
...o -- Researchers at Ohio University haveinvented a nonviral
gene therapy system that could aid scientists inthe search for a better treatment for cancer. The invention hasreceived U.S. Patent No. 5,591,601, which was issued today toOhio University. The system, developed by scientists in the university'sE...