Tag: "normal" at biology news
Genetic mutations linked to the practice of burning coal in homes in China
...to both p53, a tumor suppressor gene that prevents normal
cells from turning into tumor cells, and K-ras, an oncogene, is fundamental to the development of a vast majority of cancers. Mutations to both p53 and K-ras are thought to be primarily caused by chemicals called polycyclic aromatic hydrocarbons that...
International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...is not a condition that anyone would welcome under normal
circumstances, but an international study of a new targeted cancer treatment cetuximab has shown that patients who developed an acne-like rash responded better to the treatment than those who did not. Professor Eric Van Cutsem told a news briefing ...
Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds
...s in the cell. Chromosome fusion is detrimental to normal
chromosome segregation, which in turn leads to genetic imbalances," explained Dr. Saunders, associate professor of biological sciences, University of Pittsburgh School of Arts and Sciences, and a researcher with the Oral Cancer Center of Discovery at...
Chemical derived from vitamin-E shows early promise as cancer drug
...es. Because cancer may result from just one normal
cell going awry, Kline and former graduate student..., the cancer cells showed only 20 percent of their normal
ability to multiply and produce new cells. In addition to blocking the cancer cells' ability to divi...
Researchers find color sensitive atomic switch in bacteria
...nomic era is the crucial role of cell membranes in normal
cell function and disease states," said Spudich, who holds the Robert A. Welch Distinguished Chair in Chemistry and is a professor in the UT Graduate School of Biomedical Sciences. "Ask virtually any investigator and you'll find his or her research...
Alzheimer's disease is not accelerated aging
Certain brain changes that are common in normal
aging are not the beginnings of Alzheimer's diseas...ecutive function, which more commonly falters with normal
aging, and the decline in long-term memory typical of Alzheimer's. Executive function involves the c...
Genetic differences might help distinguish thyroid cancers
...-active or under-active in PTC cells compared with normal
thyroid cells. Genes that were inactive or under-a... six PTC tumors, nine FTC tumors and 13 samples of normal
thyroid tissue. The PTC cells showed over-expression of genes known as CITED1, claudin-10 (CLD...
UCSF scientist Joe Derisi named MaCarthur Fellow
...xpression, beginning with genes that correspond to normal
cellular processes and ending with highly specialized functions for invading red blood cells. The discovery of the pronounced level of activity, in which a gene is transcribed into messenger RNA on the path toward producing a protein, poi...
Evidence builds for potential new cancer drug target
...ia, the researchers wanted to determine the gene's normal
function. This was accomplished by deleting the c-myb gene in a mouse model. New technology allowed the scientists to delete c-myb from one specific type of tissue in the model rather than from the entire organism. "We removed the c-myb gene from T ...
Marijuana use could cause tubal pregnancies
... ovaries to the uterus. The same thing happened in normal
mice when the receptor was over-stimulated. The st...en the researchers gave a drug that blocked CB1 in normal
mice, they observed the same phenomenon in most of the mice the embryos failed to reach the uterus....
New sequence involved in DNA replication timing may aid in cancer detection
...ingly," noted Huberman, "in many cancer cells, the normal
order of DNA replication is altered: regions that should replicate late sometimes replicate early and vice versa." As a result, tests for DNA replication timing may eventually become a method for the early detection of cancer. "Replication timing ass...
Researchers ID chlorophyll-regulating gene
...pared the mutant seedlings with a control group of normal
plants. They grew the seedlings in the dark to mimic conditions beneath the soil, bringing groups out into the light at different time points throughout a six-day period. In nature, seeds are typically buried under 2 to 10 millimeters of soil, ...
Females may be more susceptible to overindulge 'sweet tooth' cravings than males
...t containing a greater portion of sugar than their normal
diet when a sweet diet is freely available, female rats consumed more calories per day than male rats when given a chance to exercise, overeating was reduced in both sexes of rats, but the caloric intake reduction associated with the exercise wa...
Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
...ding to it, but not enough to disrupt the enzyme's normal
work," White said. "So the bacteria evade the antibiotic and continue to make folate and survive." Based on the new understanding of the structure of DHPS, the St. Jude team also made a new drug-like molecule that binds to a part of the enzyme that i...
University of Alberta researcher looks for clues to mysterious disease
...al Sciences, is a basic researcher who studies how normal
cell cycles are regulated, by analyzing genes that...g number of body systems. Children with A-T appear normal
at birth but at around the age of two, some of the first signs--walking and balance is wobbly caused...
$7.5 Million grant to Yale researchers for role of viruses in cancer
...s and related cellular genes cause cells to escape normal
growth controls and induce cancer. "Because viruses are so well-defined and relatively simple compared to their host cells, we are optimistic that studies supported by this grant will continue to identify new targets for therapy and suggest new ap...
$2.7 million grant to support creation of virtual zebrafish atlas
... Cheng lab the task of creating a virtual atlas of normal
microanatomy for the growing research community. Cheng has envisioned the field using the atlas infrastructure as the foundation for development of a new approach to understanding biology that will address the problem of information overload. "We're...
Experimental drug shown to block mutant protein causing blood disease
...e abnormal kinases in cancer cells without harming normal
tissue, they are associated with fewer side effects than standard cancer drugs. In the study, mice with MPD that were treated with the oral compound PKC412 significantly outlived those given a placebo. When tested in a single patient, a 52-year-old w...
Key cell-death step found
...ogrammed cell death, or apoptosis. Apoptosis is a normal
process in healthy individuals, but if mitochondrial fusion doesn't work, the wrong cells die, causing disease. This is what happens in two neurodegenerative diseases: dominant optic atrophy, the most common inherited cause of blindness, and Charcot-...
Binocular rivalry: Fulfilling visual expectations
...pectation to influence visual perception. It is normal
to think of vision as beginning with the formation...ile binocular rivalry is rarely encountered in the normal
visual environment, it provides a useful means of probing the workings of the visual parts of our br...
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