Tag: "normally" at biology news

Erodible plastic microspheres could be effective oral drug delivery system

... can be developed to deliver a variety of drugsnot normally administered orally." She estimates that system will be createdwithin 10 years, depending on drugs and uses. Mathiowitz is an associate professor of medical science and engineering inthe Brown University School of Medicine. Other scientists on the ...

Scientists Urge Further Study Of Alarming Coral Reef Decline

...bonateskeletons show through the clear polyps; the normally coloredcorals appear bleached. They then die, usually within a week ortwo, Ostrander said. "We don't know what's causing the bleaching," he said."Furthermore, the bleaching represents only one of a variety ofprocesses contributing to the decline...

Duke Study Shows Early Marrow Transplant Key To 'Bubble Boy' Disease Cure

...e the transplant, the infant avoidsthe toxic drugs normally given to suppress the donor's T-cells. Results from the study of 79 SCID patients who received bone marrowtransplants at Duke between May 1982 and January 1997 indicate that parents,as well as siblings of SCID-affected babies, can be successful...

Researchers Find Production Point Of Key Protein In Fragile X Syndrome

...ndrome, which is caused by the geneticinability to normally produce the fragile X protein. "Fragile X"refers to the broken appearance of the X chromosome -- half the chromosomepair that determines sex -- when cells are cultured under specific conditions.The gene was found in 1969, but its relationship to ment...

Bacterium gobbles up chlorinated pollutants

...nes) in nature, but not in the high concentrations normally needed to support growth." The evolutionary origin of Strain 195 is just one of the questions on the research agenda for the Cornell microbiologists....

Genetic Trickery Offers New Way to Target HIV

...ing white cells, the type of helper T-cell thatHIV normally attacks. Substituting the primer with an inept impostor could be used in combination with other therapies, Rosenblatt says. Currently,protease inhibitors prevent the maturation of virus that hasalready infected cells, and reverse transcriptase i...

Subtle Biotic Changes Have Big Environmental Impact

...sses have powerful feedbacks to processes that are normally thought to be purely physical or chemical in nature." While lakes occupy a very small area of the planet's surface, the discovery that simple biotic change is capable of altering the exchange of carbon between the atmosphere and the Earth's surf...

Calorie Restriction Reduces Age-Related Muscle Loss

...ife can stall some of themuscle deterioration that normally accompanies aging. Reported in the June 1997 FASE...aylower production of harmful free radicals, which normally result whenmitochondria convert oxygen and food to energy. The UW researchers concentrated on two e...

Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos

...r virus from monkeys, targets key proteins that normally prevent tumors from forming, rendering them ineffective. These proteins, made by so-called tumor-suppressor genes, are in the retinoblastoma family ( pRb , pRb2/p130 , and p107 ). A viral protein called SV40 T-ag (T-antigen) binds to an...

Second Look Acquits Gene Of Role In Breast Cancer

...ns."But the string ofRNA coding for the protein is normally interrupted at several points by codingthat is not part ofthe protein. Before the cell can use it, it has to clip out these pieces. Andit's in this splicing'process that something's going wrong in the cancerous cells." In many cases, the canc...

Resistance To Leptin Contributes To Obesity

...e,found that three strains of obese mice, all with normally high levels ofleptin, are overweight because they have varying degrees of insensitivityto the protein. The team examined the effect of leptin given during a30-day period as infusions either into the fat tissue under the skin ordirectly into the flui...

Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered

...g variant. Prion proteins are chains of proteins normally present in the bodies ofhumans and animals. They cause disease only when they are folded in a particularway-luckily a very rare occurrence so far. The disease-inducing prions appear tocontain clumps of several prion protein molecules, which damage th...

Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes

..."knockout" mice, have found that two genes that normally protect against cancer may play a greater role than previously suspected in female development. In the September issue of Nature Genetics , Richard Fishel, Ph.D., and postdoctoral fellows Aaron Cranston, Ph.D. and Tina Bocker, M.D.,...

Researchers To Investigate Years Before Menopause

... a number of egg precursors begin to grow, but normally most die off, leaving one egg per cycle to ovulate. As women age, they have fewer and fewer follicles left until no follicles remain. The standard medical definition of menopause is 12 continuous months without menstrual bleeding. Be...

Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections

...uestion using macrophages in petri dish, which are normally ineffective against filamentous Candida. When challenged by Candida strains with both pathways knocked out, macrophages emerged victorious. This was good news to researchers, but the real test would come when the Fink lab scientists, in collaboratio...

Molecular Piracy Turns Protein Into Traitor

...e to shut off the inflammatory response that would normally be associated with a tumour. This means it may also be a useful tool in diseases such as rheumatoid arthritis or asthma where the human immune system is abnormally activated or even as a means of understanding transplant rejection. It may also lead t...

Trojan Horse Virus Controls Hiv Infection

...surfacereceptor -- CD4 and the coreceptor CXCR4 -- normally found on human T cells. These receptors enable HIV to attachto, enter and infect T cells. These receptors also permit cell-to-cell HIV infection to occur. HIV-infectedcells flag themselves for destruction by the body'simmune system by displaying ...

Largest Tyrannosaur Fossil Unearthed In Montana

.... The femurs or thigh bones, which paleontologists normally use to estimate thesize of dinosaurs, await excavation at the site. Unfortunately, former owners of the cattle ranch on which the fossilswere found entered the site and began digging up the bones that remained in theground, including the skul...

First Selenium-Based Orally-Active Antihypertensive May Lead To New Family Of Therapeutic Agents

...ted in the journal NatureMedicine , showed that a normally benign virus can mutate and causeheart damage in experimental animals that have a selenium deficiency. Four patents have been issued for the compounds. Georgia Tech's research on selenium-based antihypertensives wassponsored by the U.S. National I...

Recombinant Protein Immunizes Mice, Promises New Strategy Against Infection And Cancer

... ovalbumin. These ovalbumin-producing cancer cells normally kill unimmunized mice. "These results have led us to use the same heat shock fusion technologyto develop vaccine candidates against AIDS and other infectious diseases," saysDr. Young, who now leads a consortium of scientists from Harvard Un...

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