JCI table of contents September 15, 2004
...thors then focused on two patients whose cells did not complement one another, meaning the same gene was ...tions for both patients in the NDUFS6 gene; a gene not previously shown to be involved in this type of disease. This work shows how combining a series of a...9/11 search-and-rescue dogs exhibit few effects from exposure to disaster sites
...llowing the Sept. 11, 2001, terrorist attacks have not suffered either immediate or short-term effects fr...s for human disease. We are encouraged that we do not see significant increases in cancer and respiratory diseases."The Penn researchers compared the dogs...Human chromosome 5 final sequence analysis released to public
...lit 300 million years ago, the sex chromosomes had not yet evolved. After the split, mammals and birds developed their own methods of creating males and females. One duplicated region on chromosome 5 could eventually help explain how spinal muscular dystrophy is inherited. Researchers had known that dele...Venn diagram tactics to vet complex disease
...thors then focused on two patients whose cells did not complement one another, meaning the same gene was ...tions for both patients in the NDUFS6 gene; a gene not previously shown to be involved in this type of disease. This work shows how combining a series of a...European common frog found to use novel mating strategy
...ases them into the water. End of story. But that's not the end of the story, according to Spanish researc...females of some frog species, the common frog will not lay eggs if clasped by two males. Since as many as one-third of the eggs may not be fertilized by th...A liking for sweets, combined with novelty seeking, may predict alcoholism
... Analysis showed that sweet liking by itself was not sufficient to predict alcoholic status of an indi...ty seeking can be also found in individuals who do not have any substance-abuse problems. It has been known for some time that sensation seeking or novelty...Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
...ratory rodents. However, other research groups did not detect SV40 in NHL tumors, and recent evidence has... proteins, the results presented in this report do not support the idea that SV40 is a common infection of humans or a major cause of NHL. In the future, i...Byproduct of water-disinfection process found to be highly toxic
...f local conditions, and thus a rare occurrence, is not known. The DBPs in Corpus Christi's water were found as part of an EPA national occurrence survey of selected public water-treatment plants done in 2002. The survey reported on the presence of 50 high-priority DBPs based on their carcinogeni......buting to active destruction of healthy tissue are not well understood. A research study headed by Dr. Bana Jabri from the Department of Pathology at the University of Chicago examined a receptor on CTL cells called NKG2D that can be activated by stress-induced chemicals and has been linked to tissue dam...Research on carbohydrate metabolism receives historical recognition
...ely complementary, and one without the other would not have gone as far as in combination." Gerty Cori died in 1957. In 1960 Carl married Anne Fitzgerald-Jones and in 1966, after retiring from Washington University, was appointed a visiting professor at the Harvard Medical School. Carl Cori died i...First glimpse of DNA binding to viral enzyme
... was something we had to do, to make sure they did not interact," Mangel said. The discovery that the vir...binding region of the adenovirus protease that has not been solved by other techniques and can be used in drug design." At the National Synchrotron ...AACR applauds NCI initiative on nanotechnology
...gly are turning to smaller and smaller probes that not only act as microscopic sentinels, but also as tools capable of interfering with these processes. For this reason, the American Association for Cancer Research applauds the new initiative announced today by the National Cancer Institute to harness th...Genetic analysis rewrites salamander's evolutionary history
...t as opposed to anywhere when stressed, now appear not to be close relatives at all. And salamanders that...s shown in previous studies that these tongues are not a good way to classify salamanders, because the various types of tongues have evolved several times ...Can an old gene learn new tricks?
... can direct formation of an organ system that does not even exist in the Drosophila body. "These results demonstrate that the evolution of higher vertebrate characteristics can result from the recycling or redeployment of 'old' genes in new parts of the embryo, rather than through mutation of gene prot...Protein is key for digestive function of the pancreas
... The complex mechanisms involved in exocytosis are not entirely understood. Dr. Wanjin Hong and colleagu...s than control acinar cells. In addition, CCK did not stimulate exocytosis in VAMP8-deficient acinar cells. "These results suggest that VAMP8 plays a def...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...s being investigated as a therapeutic approach for not only cancer, but also chronic inflammation. Whethe...f V3 by HIMEC was upregulated by bFGF and TNF- but not VEGF, and its targeting with a specific antibody (Vitaxin) induced marked HIMEC apoptosis. HIMEC mig...Molecule awakens and maintains neural connections
...endrites acquire active AMPA receptors, and it was not known whether this process depended on Dasm1. Shi...quite important." While the function of Dasm1 is not yet known, said Lily Yeh Jan, the protein's structure hints that it is a receptor molecule. "The Das...Researchers identify distinctive signature for metastatic prostate cancer
... including sexual and urinary dysfunction, yet may not be needed for men whose cancers are unlikely to sp...actively metastatic. In contrast, cells that were not metastatic showed low levels of activity. In particular, said Beachy, their experiments showed that ...ConocoPhillips & Conservation International launch 'Biodiversity Action Plan' in Venezuela
...tant to work with companies like ConocoPhillips to not only minimize their own environmental footprint, b...c invertebrates (microcrustaceans, mollusks, etc.) not previously known to exist in the region. Additionally, the team discovered two fish species and fiv...Columbia research to examine gene influence on severity of peridontal disease, therapy response
...nt system for classifying periodontal disease does not have a solid, pathobiology-based foundation," said Panos N. Papapanou, D.D.S., Ph.D., the principal investigator on the project, who is also professor and chair of the Section of Oral and Diagnostic Sciences and director of the Division of Periodonti...