ALL survivors bear genetic damage from life-saving chemotherapy
...ed during their bout with cancer." Finette noted that children who are cured of ALL after chemotherapy have a 5-20 times greater risk of developing secondary malignant neoplasm's as well as other complications. Subsequent illnesses may be associated with increased changes in the patient's genes res...Gene alteration points to longevity, thinness
...ll it humanizing the worm," Dr. Ganapathy says. He noted an interesting difference between worm and human genes is that the human Indy gene is more adept at transporting tricarboxylates or citrates, a primary precursor for fat and cholesterol. "If you find a drug which can block the function of this transp...Kaposi's sarcoma virus 'reprograms' blood vessel cells into lymphatic cells
...th may be targets for potential new therapies." He noted that the study's first author Young-Kwon Hong, PhD, a member of Detmar's research team at the CBRC is studying how Prox1 is activated and looking for additional factors involved in the "lymphatic switch" produced by KS virus infection. Detmar is a...A fly's taste experience is much like our own
...cts sugar with its proboscis, it just eats." Scott noted that flies, like mammals, probably also have sour and salt taste receptors, but these have yet to be characterized in any animal. Mammals have a fifth taste receptor, umami, which means "savory" in Japanese and corresponds to the glutamate receptor, ...APS Inflammatory Bowel Diseases Translational Research Conference, Sept. 8-11
...ntations, the meeting will feature symposia led by noted researchers on the following subjects: Genetics of IBD Role of the immune system in intestinal inflammation: Who are the players and what do they do? Innate immune responses in IBD: Role of the vasculature Cytokines, chemokines and mediators ...North Shore-LIJ research collaboration with Correlogic Systems to advance ovarian cancer blood test
...an instrumental role in forming this partnership," noted Rep. Israel. "After final validation, these new technologies could diagnose ovarian cancer in its early stages, when survival rates are dramatically higher than in later stages. It is only fitting that this research is conducted on Long Island, where...New national research effort needed to secure clean, adequate water supply in coming decades
...ater-use challenges that lie ahead. The committee noted that overall federal funding for water research has been stagnant in real terms for the past 30 years, and that the portion dedicated to research on water use and related social science topics has declined considerably. For example, while other fiel...Trapping carbon in soil key for protecting global food security, dealing with climate change
... of carbon released into the atmosphere as CO2. He noted that the United States and some European Union countries already have CO2 emission-reduction policies in place. For example, the U.S. government has mandated an 18 percent decrease in CO2 and other greenhouse gas emissions by 2012. But until we find ...Canine word-learning research published in Science
...boxes, or to bring them to certain people. Fischer noted that people should not take this study as a reason to go out and get a Border collie as a novelty. "Border collies are working dogs," Fischer said. "If they were humans, we'd call them workaholics. They are high-maintenance, professional dogs that ne...LARGE protein can overcome defects in some types of muscular dystrophy
...utical approach may be more appropriate. Campbell noted that the researchers had observed that even in normal tissue, LARGE increased the binding of alpha-dystroglycan to the extracellular matrix. This suggests that LARGE may be able to improve the link between muscle cells and their surrounding matrix ev...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...metastatic setting (n=33), a 24% response rate was noted after receiving weekly ABRAXANE TM ; Of those pat...etastatic setting (n= 31), a 16% response rate was noted after receiving weekly ABRAXANE. "The demonstration that 15% of patients responded to ABRAXANE TM ...Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
... estrogen/progesterone combination. Dr. Pazol also noted a marked reduction in sexual activity during the estrogen/MPA treatment period. "Our findings suggest MPA may be affecting certain neuroendocrine systems in a very different way than natural progesterone," explained Dr. Pazol. "In comparison...Study links diabetes and colorectal cancer
...ly through the level of glycated hemoglobin." Khaw noted further that glycated HbA1c could predict colorect..., seemingly disparate conditions. Researchers had noted the prevalence of overweight and obesity in the U.S. and much of the Western world leading contribu...Tiny tango: Device sorts microscopic particles with speed and precision
...kly the drug is absorbed and excreted in the body, noted Sturm. "You can use advanced chemical engineering methods to create particles of a certain size, but once you have done that there is not a lot you can do to filter out exact sizes and check the quality," Sturm said. Huang said the device ...Margaret Foti to be honored for significant contributions to cancer care
...ntials of effective clinical trials design." They noted also Foti's efforts "to provide vital links between translational scientists and clinicians," and her fostering of "important connections between these two research groups." "I am deeply honored to receive this award, which is all the more meaningful...RNAi delivery system crosses blood-brain barrier to target brain cancer
...radiation in the brain cancer cells, Dr. Pardridge noted minimized DNA replication, and hence, cellular proliferation, in the cancer cells that were treated with the immunoliposomes. Tumors in the treated mice had reduced EGFR content, and the mice showed an 88 percent increase in survival time. The resea...Umbilical cord blood transplants, bone marrow transplants save lives
...w, healthy blood can be produced," said Stiff. He noted that cord blood matching is less restrictive than that of bone marrow, which must be perfectly matched between donor and recipient for best results. Each year in the U.S., 10,000 to 15,000 people are unable to find a suitable bone marrow donor amon...Are bacteria turning our own weapons against us?
...succumb to the host's immune defenses." Budd also noted that the gene didn't show a typical pattern for inheritance. In a normal case, he explained, if a gene is found in animals and bacteria you would find this gene distributed throughout many other organisms like plants and yeasts. But in the case of &...Genomic imprinting in disruptive spermatogenesis
...nt and malignant disease, and have been previously noted in oocytes (Lancet 2003; 361: 1975-77), but this is the first report showing imprinting defects in sperm. To investigate whether abnormal genomic imprinting could be associated with disturbed spermatogenesis, Professor Mario Sousa and colleagues extr...Study of Cape Cod Seashore finds off-road vehicles harmful to beach fauna
... and diversity of species on the beach." Steinback noted that the beach ecosystem is very variable because environmental conditions change from day to day. As a result, species composition changes daily as well. "The important thing is that the Park Service is doing a good job of protecting most of the s...