UCSD team determines cellular stress within body is critical
...sponse pathway that is controlled by a gene called nuclear factor of activated T cells 5 (NFAT5)/tonicity enhancer binding protein (TonEBP). This NFAT5/TonEBP protein is the only known mammalian transcription factor that is activated by hyperosmotic stress. Steffan N. Ho, M.D., Ph.D., a UCSD assistant profe...Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
...donors. Using the cloning technique somatic cell nuclear transfer (SNCT), the researchers removed the nucleus of each unfertilised egg and replacing it with the nucleus taken from a cell from the cumulus the clump of cells that surrounds the egg - of the donor. The eggs were then stimulated to begin div...Hopkins to found first center for comprehensive study of epigenetics
...nimals and stem cells created through somatic cell nuclear transfer, a process colloquially known as "cloning." As part of the center, Feinberg and his colleagues will also implement a "minority action plan" to encourage racial and ethnic minorities to pursue education and careers in genetics and genomics. T...Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
... internal structures. Both MRI and MRM make use of nuclear magnetic resonance, a phenomena observed in the nuclei of atoms when they are exposed to a magnetic field and pulses of radio waves. MRM uses stronger magnets to capture images at a resolution 10-100 times finer than conventional MRI. Using MRM, Ahr...Melting ice cap gives urgency to new census of marine life project in Arctic Ocean
...sources or those known or suspected for dumping of nuclear and other wastes." While sampling the entire Arctic is unrealistic, "any effort" directed specifically at understanding biodiversity can result in "tremendous advances" to science, the researchers say. Scientific questions to be addressed include whe...New technique images gene expression in mice
...r the diagnosis, staging, and treatment of cancer; nuclear cardiology; and the collaboration between nuclear medicine and bioengineering in the fight against cancer....Therapeutic cloning may be permitted at Newcastle University
...the first license to begin research involving cell nuclear replacement (therapeutic cloning), focusing on the...d and use their knowledge in stem cell biology and nuclear transfer technique to bring faster and more efficient stem cells from the bench to the patient's bed...Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics
...however." It is possible to use a procedure called nuclear transplantation to replace the DNA of an embryonic stem cell with DNA from one of the patient's own cells, eliminating the problem of immune rejection. In another approach, differentiating small numbers of ESCs into blood cells and injecting them int...Whole body imaging allows better understanding of the immune system
... (chemists, engineers, physicists, mathematicians, nuclear medicine, and others), he is looking for targets within the immune response - and targets that he will be able to track using this new technology. "When a new tool comes into biology, it always accelerates our understanding of a problem," s...Strengthening independent junior research groups in collaborative research centres
... atmospheric research, exotic states of matter and nuclear physics. The decision made by the responsible Grants Committee on 24 and 25 May 2004 brings the total number of Collaborative Research Centres funded this year to 272, located at 61 universities, including 19 Transregional Collaborative Research Cent...Gene mutation causes progressive changes to cell structure in children with Progeria
... and molecular techniques were used to examine the nuclear structure of cells from children with Progeria. A..., there was a gradual increase in defects in their nuclear structure and function, reflecting an abnormal accumulation of the defective Lamin A protein. Very ...Yale professor receives Johnson & Johnson Focused Giving award
...on of one of the protein subunits (Rpp38) in human nuclear RNase P turned off the expression of some, but not all, subunits without further cell manipulation. The research will use external guide sequences (EGS), RNA sequences that bind to the target RNA so that the complex looks like a normal ...Scientists track protein linked to movement disorder
.... The TorsinA that was stuck to ATP moved into the nuclear envelope, the portion of the endoplasmic reticulum... torsinA is probably taking something apart in the nuclear envelope," Hanson says. "The questions are: What is it taking apart and how is that important for th...JCI table of contents, 17 May 2004
...pression levels. SHP, an FXR target, represses the nuclear receptor LXR. LXR is essential for a basal transcription level of SREBP-1c. The authors analyzed the SREBP-1c promoter using luciferase assays to show that SREBP-1c expression was attenuated via the FXR/SHP cascade. Finally, SHP/ mice as well as LXR_...High Flux Isotope Reactor marks 400th cycle
...o become depleted. During operation, HFIR uses the nuclear fission process to produce the world's most intens...k. The reactor also produces radioisotopes used in nuclear medicine. HFIR is the only domestic source of californium-252, an isotope used in industrial analysi...Landmark conference for United Nations on human cloning and stem cell research
...e leading scientists in the fields of somatic-cell nuclear transfer, in vitro-fertilization, experimental biology and regenerative medicine. The conference will be moderated by Gerald Fischbach. M.D. of Columbia University and include: Dr. Dalton Dietrich of the Miami Project to Cure Paralysis (USA) Dr....DFG establishes first German-Sino Research Training Group
...developed and applied on experimental particle and nuclear physics, whereby physicists will be brought together with information specialists to explore particle physics, working with the most progressive design, simulation and analysis tools. In "Medial Historiographies", one of the newly established Researc...Study is another step in determining if curry can protect against Alzheimer's
...pression of HO-1 protein at both cytoplasmatic and nuclear level, as shown by immunofluorescence analysis under laser-scanning confocal microscope. The researchers also found a significant expression of quinone reductase and glutathione S-transferase, two members of Phase II detoxification enzymes, in astro...High-fat fast-food breakfast produces rush of inflammatory factors into blood stream, UB study finds
... study focused on a pro-inflammatory factor called nuclear factor-kappa B (NF-?B), which regulates the production of several inflammatory mediators and free radicals. "This pathway was activated in all subjects following food intake and resulted in the production of several inflammatory mediators regulated b...Society of Nuclear Medicine's 51st Annual Meeting June 19-23, 2004
...atives of the media are invited to join over 3,600 nuclear medicine physicians, scientists, pharmacists, and ...kthroughs and discuss the critical concerns facing nuclear medicine today. It all happens at the Pennsylvania Convention Center in downtown Philadelphia when t...