First Reproducible Cloning Of Mammals From Adult Cells Reported In Nature
...ningtechnique. Using a special pipette, the donor nucleus is microinjected into an eggwhose nucleus was previously removed. The researchers cultured the resultingcell, placed it in a surrogate mouse a...Dismantling Dangerous Genetic Codes With A Faster, More Flexible RNA Mimic
...acid)is a double-stranded molecule, located in the nucleus of every human cell; itcontains the genetic plans of the genes contained on 46 chromosomes. RNA(ribonucleic acid) is a single-stranded molecule that acts in tandem with DNA. It is responsible for carrying out the plans of DNA by directing the format...Genetically-Altered Crops Can Produce Tough, Hard-To-Kill Weeds
...nt cells, instead of the nucleus. The DNA from the nucleus gets into every pollen grain of a plant, and willtravel far and wide on the wind, or hitch a ride with pollinators such as bees. But a gene in the cytoplasm could only be inherited through the seeds of aparticular plant. In the future, Snow w...UNC Scientists Succeed In Inserting Gene In Human Cells Via Artificial Chromosome
...of any of the 46 original chromosomes in each cell nucleus byinserting itself into them, but it is in additio...us' ability to replicate andmaintain itself in the nucleus of human cells. The virus serves as a vector, orcarrier, of the human genes, something like attachin...University At Buffalo Team Discovers How The Cell Nucleus Orchestrates Genetic Processes
...w an exquisitelyorganized architecture in the cell nucleus controls precisely when and wheregenetic processes...how orchestrates certain regions or "zones" in the nucleus toengage in, or refrain from, transcription or replication at designated times. The research provid...Molecular Basis Of Leading Genetic Cause Of Infant Death Discovered
...version of pre-mRNAto mRNA takes place in the cell nucleus in a process called splicing. It is acritical step in the pathway of gene expression, and ultimately, in theproduction of a functional protein. This genetic splicing is analogous to splicing a film together--gettingthe right sequence, cutting...New Insight Into Genetic Cause Of Infant Mortality
...ersion of pre-mRNA to mRNA takes place in the cell nucleus during a process called splicing. Splicing require...vely large size of these cells, which requires the nucleus to "crank out a tremendous flow of mRNA." The description of the molecular machinery underlying the...Shedding Light On Circadian Rhythms
... CRY2 areconnected directly to the suprachiasmatic nucleus (SCN), a group of neurons deepin the mouse brain. The SCN has long been thought to be a crucial circadianpacemaker in mammals. They also knew that expression of the Cry1 gene within theSCN follows a circadian pattern. In the mouse retina, however, CR...Tracking A Killer's Progression
...athogenic bacterial proteins are known toenter the nucleus of cells. "This finding raises the intrigu...vesicles arise. YopM may act to prevent enter the nucleus by itself or it maybecome associated with a protein. Once the nucleus is invaded, YopM may act topr...Quality Control System Ensures Genetic Instructions Are Ready To Go
...rchers. Before sending geneticmolecules out of the nucleus to sites where they will ultimately function, cell... more than ashell that keeps the components of the nucleus together," said UW Medical SchoolProfessor of Biomolecular Chemistry Dr. James Dahlberg. "We now kno...Gap Widening Between Genetic And Behavioral Research
...lar-level events that occur immediatelyoutside the nucleus of a cell. To bridge the chasm, he says, "we need a new way of talking about andconceptualizing health research," one that incorporates multiple levels ofresearch. "The interpretation of findings from single-level research might benef...Researchers Discover Mechanism That Drives Daily Body Rhythms
...theeyes, in a structure called the suprachiasmatic nucleus (SCN), but they knewlittle about the molecular workings of the clock -- the genes and proteins thatmake the clock tick on a 24-hour basis. Over the past eighteen months, they havediscovered that the clock consists of at least six proteins that engage...Wolf Prize In Medicine Awarded To Kandel, Columbia's Pioneer Of Memory Research
...ouptraced the formation of long-term memory to the nucleus of the neuron and showedthat the series of biological signals that leads to a memory ends with a molecule called CREB. CREB switches on dozens of genes that stimulate thegrowth of synapses, which lead to the formation of persistent, long-termmemorie...Gene Therapy Trial Approved For Rare Anemia
...hen packaged with a retrovirus, can enter the cell nucleus and enableformation of the millions of healthy blood cells that are needed every day. Fanconi anemia affects an estimated 2,000 to 3,000 people in the United Statesand Europe. Given these relatively small numbers, Walsh says he hopes to enrollat leas...Study Finds Protein Clues To Early Embryo Development
...ssion, Ingledue says. SLBP1 was found in both the nucleus and cytoplasm. SLBP2 occurred only in thecytoplasm. "And if a protein is found only in the cytoplasm, that suggests thatit does not have any nuclear functions," Ingledue points out. Subsequent testsrevealed that to be true. SLBP2 did not assist in th...Heavy Traffic At The Nuclear Pore: How Proteins And RNA Leave The Cell Nucleus
...c macromolecules through nuclear pores in the cell nucleus (Nature, Vol.397, 4 March 1999). Cells from higher organisms contain a nucleus which is a sealed-off compartmentof the cell containing the genetic material. However the nucleus is......he EGF receptor complex sends a signal to the cell nucleus to turn onthe mucus gene, MUC5AC. The messenger, the researchers found, is a much-studiedenzyme known as EGF receptor tyrosine kinase. The site where the mucus production sequence begins had not been known before,nor had the role of tyrosine kinase a...Debate Brews Over Caffeine Addiction
...rugs trigger functionalactivityin the shell of the nucleus accumbens, the part of the brain responsible foraddiction, she says. It would take the equivalent of about seven or more cupsofcaffeinated coffee consumed in rapid succession to begin to activate thisportionof the brain. Even then, she adds, "acti...Researchers: 'Exciting' Discovery Might Improve Cancer Treatment
...kappa B, a protein that attaches to DNA inside the nucleus of cells and turnsgenes on and off like a switch. Doctors use chemotherapy or radiation to killcancer cells, but the UNC-CH researchers reported two and a half years ago thatNF-kappa B kicks in and soon enables many cultured tumor cells to escape dea...