Study Suggests New Approach To Asthma
...is activated, a protein called Stat1 moves intothe nucleus and switches on certain genes. The products of the...s, presumably switching ongenes. Stat1 enters the nucleus after one of the JAK proteins gives it a phosphategroup. The researchers found phosphorylated Stat1 ......aphase called S for synthesis, when the DNA in its nucleus is replicated and thecopied DNA is checked for mistakes. In a third phase, G2, further checking goeson and repairs are made. Finally, assuming the cell passes its own internalquality control mechanisms, the M phase -- mitosis -- divides the DNA equal...Researchers Track Path Of Safer Gene Delivery Method
...rprising--that PEI actuallydelivers the DNA to the nucleus without separating from the DNA--they get in asint...ntcolors, to verify that the complex gets into the nucleus intact. Exactly how the DNA-polymer complex enters cell nuclei is not yetexplained, but the...Discovery Of Mechanism Causing Colon Cancer
... beta-catenin, preventing it from traveling to the nucleus and excessively stimulating the production of the cyclin D1 protein. A patent application for this method has been filed by Yeda Research and Development Co., the Weizmann Institute's technology transfer arm. These types of intervention may provide t...UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
...nce. This method allowed delivery of PNAs into the nucleus in almost 100percent of the tests on two different cell lines, Corey said. One of the most significant aspects of the work, especially in relation todeveloping anticancer drugs, is that seven out of 10 of the PNAs tested thattargeted different region...Mouse Map Leads Way To Human Disease Exploration
..." she said, describing three bright spots in every nucleus ofa mouse's cells. Indeed, the error can even be seen in embryonic mouse cells,holding the promise of developing cures that could one day be carried out infetuses with Down Syndrome so that babies would be born without the disease. "We are quite exci...Study Reveals Cancer Role Of Mutated Gene
...rotein. It allows p53 to accumulate in the cell's nucleus where it functionsto stop tumor cell growth. "We p...isstructure prevents MDM2 and p53 from leaving the nucleus and entering thecytoplasm, where the proteins would otherwise be degraded, broken down. "When these ...Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
...ers of a family ofprotein molecules located in the nucleus of cells found in the liver, intestine, kidneysand adrenal glands. Their role in removing cholesterol from the body isimportant because it prevents arteriosclerosis, which leads to heart attacks. This study showed that elevated bile acids reg...University of Hawaii scientists announce first male clone
...f adult male tails. In the Honolulu Technique, the nucleus extracted from a donor cell is injectedinto enucleated egg from a separate female (an egg cell from which all geneticinformation has been removed). The eggs are activated to begin dividing and thedeveloping embryos transplanted into a foster mother. ...Nematode makes scientific history
...sm. Yeast was the first organism with an organized nucleus to have itsgenome completely sequenced, but it is single-celled. Caenorhabditis elegans is a hermaphroditic, non-segmented roundworm-like animalwith skin, muscles, and alimentary, nervous, excretory, and reproductivesystems. It contains 959 cells, of...New mechanism for regulating gene expression discovered
...to messenger RNA (mRNA), the 'copy' moves from the nucleus to the cytoplasm ofthe cell, where the mRNA is 'tr...lso can regulate the movement of the mRNA from the nucleus to thecytoplasm. Their experiments confirmed the new role for TRA-1 protein by showingthat i...Target for cystic fibrosis drugs found
...y, which tries to correct the geneticdefect in the nucleus of cells, upstream of the chain of events that makethe CFTR protein. Several gene therapy clinical trials have been conducted,but Pedersen says the early overemphasis on this approach reduced fundingto study CFTR. "One alternative to gene therapy is ...New components of machinery that carries genetic information from nucleus
...t for regulating howgenetic information leaves the nucleus to begin its working life as a blueprintfor the ce...g calcium, it ends with the export ofmRNA from the nucleus as mediated by IP6. We now want to find out what are thesignaling roles of each molecules along this...Head trauma damages DNA repair mechanism
...hat a cell's ability to detect damage toDNA in its nucleus is also impaired for months after an injury. The DNA in humancells is assaulted everyday by all sorts of damaging agents -- ultravioletradiation, chemicals, and heat, for example -- but normally the body has avigilant surveillance system in place to ...APS launches new online journal to focus on link between genes and function
...cesses from the initial actions of geneswithin the nucleus through cellular processes to the functions of tissues andorgans and ultimately to the workings of the organism," Dzau pointed out, notingthe enormous implications of this development for clinical medicine: "We willsoon have the opportunity to assess......ich islike a long computer tape," Luger said. "The nucleus of every human cell has atwo-meter strand of DNA in a compartment one one-thousandth of a millimeteraround. "You can't just ball the strand up and stuff it in there, because thecell needs access to the information that is stored on the strand...New UNC-CH study explains variations in onset of ice ages
... - oxygencontaining two additional neutrons in its nucleus compared with standard oxygen- corresponds to colder temperatures. That the geologic record shows ice ages occur every 80,000 to 120,000years has confounded researchers who felt such astronomically controlled eventsshould occur on a more prec...Gene therapy trial using cold virus to begin at UK
... a correct copy of themutated gene directly to the nucleus of the abnormal cells, thereby restoringnormal function of the gene. To insert the corrective gene into the nucleus, the corrective gene canbe encapsulated in liposomes, small balls made of molecules that resemble cellmembranes, or viruses. ...New gene therapy found safe for treating coronary heart disease
...n a cell's surface, one of them will make itto the nucleus and deliver the gene. Both bypass surgery, which routes blood around a blocked section of anartery, and angioplasty, in which a balloon is inflated inside a clogged arteryto open the vessel, are effective treatments for coronary heart disease...