Unique study reveals new details on how genes are transcribed
... genetic messages stored within the DNA inside the nucleus of a living cell are read by the RNAP enzyme and t...RNA) which then carries the information out of the nucleus and into the cytoplasm where protein assembly takes place. RNAP transcribes a gene by tightly clampi...Northwestern team identifies first enzyme in mammalian circadian clock
...ach a peak level, at which time they return to the nucleus and "shut off" the switch by inhibiting the CLOCK-...proteins build up earlier and return to the cell's nucleus ahead of schedule to inhibit CLOCK-BMAL1. In other words, the genetic switch gets turned off earlier...Novel antiviral drug concept targets number of human viruses
... Indeed, most viruses that replicate in the cell nucleus are potential candidates for the cdk inhibitor antiviral approach, according to the Penn scientists. Thus, members of the adenovirus, papovavirus, and parvovirus families are among the possible targets -- as is HIV. At least one cdk inhibitor, a dr...New fertility technique to help women have own genetic baby from donor egg
...el method of membrane fusion which would allow the nucleus from the egg of an infertile women to be successfu...d into the cytoplasm of a donor egg from which the nucleus had been removed. As the nucleus carries most of the genes, transferring it to an enucleated donor e...Scientists find unique nuclear DNA structure
... two processes that alter the DNA blueprint in the nucleus - one of only two DNA-cutting and - joining processes in all animal cells." The other nuclear recombination event is closely related - the process that creates the antigen-binding pockets topping the short arms of the immunoglobulins.] "We've identif...BRCA1 cancer gene plays pivotal role in DNA control complex
...cular strand of genetic instructions stored in the nucleus of every cell. To keep order, nature has developed a method of tightly packaging the DNA to make genes inaccessible for transcription. The DNA wraps around small proteins called histones and then further coils into a higher order structure called chr...U-M scientist finds molecule plants use to control early cell development
... carry these chemical signals to genes in the cell nucleus telling them to turn off the locking signal that keeps meristem cells from developing. Once the locking signal stops, the meristem begins forming a tiny plant shoot, which will grow into a stem and, eventually, leaves and flowers. "We know of over 1...New gene monitors cell division, cancer clinical applications seen
...eart of this process is mitosis, in which a cell's nucleus duplicates its genetic material and divides. Precisely controlled mitosis is vital to survival, and rigorous checkpoint mechanisms are in place to ensure that each step in the process is properly executed before the cell moves on to the next step. Al...Molecular switch that inhibits fat cell development found
...nger molecule to another until they reach the cell nucleus where they either turn on or turn off genes that regulate development. Ross demonstrated Wnt's power to control cell differentiation by blocking proteins in this signaling pathway to interrupt the Wnt signal. After just a few days, myoblasts alr...A molecular motor's key role in cell birth
...apparatus that transfers genetic material from the nucleus of a mother cell to the daughter. The research exp... formation of new cells by which the mother cell's nucleus divides to provide a duplicate set of genetic instructions to the developing daughter cell in the fo...Feeling nauseous? Research suggests your brain plays a role
... neurons in the part of the brain stem called the nucleus of the solitary tract (NST). Cells in the NST are a critical part of the neural circuitry that regulates digestive functions, including vomiting. Rogers and his colleagu...Review article highlights tiny motors driving cell division
..., a machine called a spindle is constructed in the nucleus to move chromosomes. What researchers have found recently is that multiple protein-based motors coordinate to an extraordinary degree to build the spindle and also, probably, to move the chromosomes," said Jonathan Scholey, a UC Davis professor of ce...New mouse marks latest stride in muscular dystrophy research
...enger RNA transmits genetic information out of the nucleus and into the main part of the cell where its instr... of other proteins that normally travel within the nucleus to do their jobs. Or the extra mRNA may latch onto other molecules and prevent them from attaching w...Scientists have long pondered how, inside the nucleus of a cell, long stretches of DNA are moved through...a highly controversial observation - myosin in the nucleus - has turned out to be an important key for understanding just how cells perform the rather formidab...Scientists have long pondered how, inside the nucleus of a cell, long stretches of DNA are moved through...entists did not believe that myosin existed in the nucleus - indeed, no motor molecule had ever been found there. "We had an uphill battle to convince our coll...Searching for new medications to treat alcoholism
... Dopamine activity in the brain center called the nucleus accumbens is thought to be key to reward and experiencing the "high" of a variety of different drugs, including alcohol. Drugs can have agonist and/or antagonist properties. Agonists activate a receptor to achieve their effect. Antagonists block ...Suspect list shortens for maternal aggression's brain origins
...er researchers. For example, the paraventricular nucleus has been linked to aggression in related research ...ngs and muskrats than to mice. The paraventricular nucleus is located in the hypothalamus, a brain area where environmental stimuli are integrated with interna...Molecular clue to Alzheimer's mystery found
...s to learn that ubiquilin is localized in both the nucleus and cytoplasm in cells. The journal paper further explains that "modulation of presenilin levels by ubiquilin" may have important consequences to many cellular functions, because presenilins have been linked to various biological processes, includ...Common mode of action likely in gene-activation molecules linked to cancers
... chromosomes, of which humans have 23 pairs in the nucleus of every cell. When the DNA is tightly wrapped around the histones, the genes cannot be accessed and their expression is repressed. When the DNA coils around the histones are loosened, the genes become available for expression. Although scientists......cells (the X that was inactive in the mammary cell nucleus from which she had been cloned). In this study, scientists from Rudolf Jaenischs laboratory at the Whitehead Institute and Ryuzo Yanagimachis laboratory at the University of Hawaii used their expertise in cloning mice to answer this question. Their r...