Science researchers report 'extremely unstable' gene expression in cloned mice
...ned embryos, derived from the insertion of a donor nucleus into an emptied egg, die before birth. The clones that do survive frequently have respiratory and circulatory problems, and abnormally high birth weights. Some researchers have suggested that abnormal expression of certain genes, called imprinted...New study shows normal-looking clones may be abnormal
...ommand center, of an egg and replacing it with the nucleus from an adult cell or an ES cell. Ideally, the egg resets the developmental clock of the nucleus back to a state compatible with early embryonic growth and gives rise to a new organism that is gene...Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression
...cal Institute propose that the APP tail enters the nucleus and participates in gene expression. "This would, for the first time, provide a biological reason for gamma cleavage, which liberates beta amyloid fragment that causes Alzheimer's disease," said Sdhof. The researchers took their lead from anothe...New great white shark study has conservation implications
...of the species and particular genes from the cell nucleus passed on by both parents. The mitochondrial results indicated the "female-mediated " gene flow of great whites between different ocean basins is rare and exhibits significant differences between sharks from the Australia-New Zealand region and the ...Structure shows repair protein cradling broken DNA
...is very clear, Goldberg said. Ku is sitting in the nucleus ready to sense DNA damage and to bind to DNA ends. What remained unclear, however, was how Ku was able to distinguish between broken ends and intact DNA with such precision. Also, stitching DNA back together sounds dangerous because of the likelihoo...Wistar study offers new support for a 'histone code' theory of gene regulation
... chromosomes, of which humans have 23 pairs in the nucleus of every cell. When the DNA is tightly wrapped around the histones, the genes cannot be accessed and their expression is repressed. When the coils of DNA around the histones are loosened, the genes become available for expression. The "histone code" ...A closer look at the genomes black holes
...roteins called histones, with which all DNA in the nucleus must associate in order for it to form beadlike structures called nucleosomes that bind DNA into compact packages. In the Science article, Henikoff and his colleagues suggest that the uniqueness of the centromeric histone H3 may teach researchers som...Sleepless aged rats show biological clock problems
... and other mammals is found in the suprachiasmatic nucleus (SCN), a part of the hypothalamus that can be found on the bottom of the brain just above the roof of your mouth where your optic nerves cross. There are roughly 10,000 cells in this nucleus. The timekeeping mechanism in these cells depends on dail...New insight into diet and colon cancer
... A signal can go from the cellular membrane to the nucleus of the cell and tell it either to divide and become a tumor or give up the ghost and undergo programmed cell death." With help from the group of statisticians led by Carroll, the scientists have also determined for the first time how cancer spre...UC Davis' first cloned calf born, succumbs three days later
...nuclear transfer because it is based on moving the nucleus of one cell into another cell.The nucleus -- the center part of the cell that contains its DNA -- is withdrawn from an egg cell of one animal....Laser technique examines movement in nucleus of living cell
...movement of chromatin (tiny packets of DNA) in the nucleus of a living cell. DNA, in the form of chromatin, plays a key role in several important chemical reactions that occur in living cells, said Christopher Bardeen, a UI professor of chemistry. Understanding how chromatin motility affects reactions, lik...Findings on cell communication may help fight three genetic diseases
...ool of Medicine into the communication between the nucleus and cytoplasm of cells may aid in the development ...ulate the transfer of genetic information from the nucleus to the cytoplasm and the structure of its nucleus. This is important because it was previously thou...Gene therapy reduces drinking in "alcoholic" rats
...nism to deliver the gene to the brain cells in the nucleus accumbens, the brain's pleasure center, so the cells can make the receptor protein themselves. To see if the D2 receptor levels actually did increase, the scientists studied the brains of one group of rats using sophisticated imaging techniques. The...UGA researcher unlocks links between complex carbohydrates and spread of cancer
... the cell surface and send information back to the nucleus - information that influences whether a cell divides, stays in one place, or migrates to another part of the body. When a cell becomes cancerous, its carbohydrate branches change and so do the messages sent back to the nucleus. Starting with the al...Two routes to cell death in the diseased kidney
...family, which are activated and transported to the nucleus following TGF-b treatment. Schiffer et al. show here that there are surprises left in this widely studied and highly conserved pathway. Overexpression of TGF-b1 under control of the Albumin promoter causes apoptosis in renal epithelial cells and yiel...Gene therapy technique reduces alcohol consumption in rats
...agent, to carry copies of the DRD2 gene to the rat nucleus accumbens, the brain area associated with the reinforcing effects of alcohol. Supplying copies of the gene in this manner enables the rat brain cells to manufacture larger amounts of DRD2 receptors than they would ordinarily. Strong evidence from ph...Moving gene in plant results in increased production of amino acid
...he genes encoding these enzymes are located in the nucleus and the proteins are imported into the plastids. Plastids in todays plants are believed to have evolved some 2 billion years ago from a unicellular, photosynthetic cyanobacteria containing its own set of genes that was engulfed by non-photosynthetic ...Female vulnerability to drugs tied to estrogen, U-M researcher reports
...s dopamine in two specific areas of the brain, the nucleus accumbens and the striatum. These brain areas are known to be important in behaviors such as eating, sex, and compulsive drug use. "My lab has demonstrated that estrogen has rapid effects that boost the amount of dopamine released," says Becker. "T...Molecular basis of mental retardation uncovered
... carry genetic information (DNA) froma body cell's nucleus to its protein-making machinery - yet the specificmRNAs involved as well as the overall purpose of this protein remainedelusive. Now, the researchers present several important clues, which togethersuggest that FMRP may turn up or down the production ......blocks the export of messenger RNA (mRNA) from the nucleus to the cytoplasm of living mammalian cells. The te... 2001, issue of Science . Export of mRNA from the nucleus to the cytoplasm takes place through a pore complex in the membrane of the nucleus. Export is believ...