U. of Colorado researchers identify switch that controls aging in worms
...ex. The key to DAF-16 is whether it penetrates the nucleus of cells, said Henderson. "When it does penetrate...they consume sugar, inhibiting DAF-16 to enter the nucleus of the cells. It is likely that the same process occurs in other animals, he said. Henderson has id...Cloning primates is turning out to be a real challenge
... created by nuclear transfer-plucking out an egg's nucleus and then adding a nucleus from a donor cell. She followed development of the embryos through several divisions, from the two-c...Protein discovery tied to DNA master switch
...k about genes, we're talking about DNA in the cell nucleus that's complexed with several basic proteins called histones. The basic structure is like 'beads on a string' which can be further packaged into a high order structure called chromatin," he explained. "This chromatin packaging allows for efficient ...Scientists find alcohol, drugs boost endorphins in key forebrain region
...The name of this important forebrain region is the nucleus accumbens. We and others had suspected this respon...w whether nicotine increases beta endorphin in the nucleus accumbens or whether it acts on different systems, he said. Such information should contribute to ef...Control of fat cell development demonstrated using Sangamo BioSciences' ZFP technology
...ns. Transcription factors, which are found in the nucleus of every cell, bind to DNA to regulate gene expression. The "designer transcription factors" made from ZFPs allow precise targeting to a particular gene or genes of interest. Since the over-expression or under-expression of individual genes is the ba...Tiny molecular change inactivates tumor suppressor gene in neurofibromatosis
...rs when messenger RNA is edited before leaving the nucleus of the cell. Cells that did have the change, however, seemed to be more aggressive tumors, and a substantial percentage was malignant. Since patients inherit two copies of the NF gene, most researchers believe in a two hit mechanism that launches neu...Fly cells on the move may reveal clues to cancer metastases
...tivator of transcription). STAT can then enter the nucleus and activate certain genes. Not only do polar cells normally make Unpaired, Silver found that any epithelial cell that produces Unpaired will be whisked across the egg chamber by its neighbors. "Releasing Unpaired and turning on the JAK/STAT path......f painstaking work with a microscope to remove the nucleus of an egg cell and replace it by fusing the denucleated egg with another cell. "If somebody's got something like that, obviously it would make everybody's life easier," says Tanja Dominko of Advanced Cell Technology, the Massachusetts company that c...Tidying up transcription factors
...t the cell that all of the proteins outside of its nucleus were grouped into one big "cytoplasmic soup." Now,...ytoplasmic factor which upon activation enters the nucleus to function in activating gene transcription." The researchers hope the paper will foster vigorous d...E. coli bacteria make Alzheimers-linked fibers
... a snowflake on a dust particle. The particle is a nucleus that triggers the precipitation of ice crystals at...icles in snowflake production, each B protein is a nucleus that triggers the precipitation of dissolved A-proteins. As the A proteins pop out of solution they ...Tracing the neural circuitry of second sight
...rcadian control center, called the suprachiasmatic nucleus (SCN), said Yau. A key discovery, said Yau, was the identification of a candidate circadian light-sensing pigment, melanopsin, from the retina by Ignacio Provencio and his colleagues at the Uniformed Services University. Yau and his colleagues sought...Chemical evidence proves the old adage, Birds of a feather flock together
...e most abundant carbon isotope is carbon 12, whose nucleus is made up of six protons and six neutrons. A small percentage of carbon atoms carry an extra neutron and therefore are known as carbon 13. Hydrogen 1 (the most common hydrogen isotope) only has one proton and no neutrons, but a rarer form deuteriu...Scientists prove mature adult cells can be cloned
...ommand center, of an egg and replacing it with the nucleus from an adult donor cell. Ideally, the egg resets the developmental clock of the nucleus back to a state compatible with early embryonic growth. This ball of cells growing in culture gives ...Study shows plants inherit traits from more than gene sequence alone
...of gene expression. The location of DNA within the nucleus also influences gene expression. Stokes makes the...ison to a landscape. "There are some parts of the nucleus that are like deserts where not much is happening. And others are like lush forests where a lot of a...Single cell type seems to control internal clock and pupil of eye
... geniculate and an area near the olivary pretectal nucleus in the brain stem). Much remains unknown about melanopsin itself, including whether it is sensitive to light, and about these cells' roles in controlling the clock and pupil, the researchers stress. "The genetically engineered mice give us an importa...A new strategy for treating psoriasis
...cing I-kB, thus preventing NF-kB from reaching the nucleus and trans-activating its many target genes, including those involved in T cell-dependent inflammation. Zollner and colleagues now propose a different means to this same end: Since the proteasome is responsible for the regulated turnover of I-kB, prot...Scientists combine therapeutic cloning, embryonic stem cells, and gene defect in mice
...DNA of a cell, from an egg and replace it with the nucleus from a skin cell of an adult mouse with a genetic ...he egg resets the developmental clock of the adult nucleus and the reprogrammed cell starts developing into an embryo that is genetically identical to the dono...Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
...rons of the hippocampus; those that survive in the nucleus show elevated expression of galanin. However, a n...d rat cholinergic basal forebrain neurons from the nucleus of the diagonal band of Broca (DBB) using a combination of whole cell patch-clamp and single-cell re...Epstein-Barr virus mechanism for long-term survival discovered
...nd out what allows EBV to survive in the host cell nucleus as an independent genome for such a long time. They knew that when the virus replicated in the dormant stage, it maintained stable copies of its genome even as the cell divided, and in this way maintained itself in the daughter cells. They also knew ...Researchers find synthetic molecules that may literally be the key to 'locking away' unwanted DNA
...ivered not only into the correct cell but into the nucleus as well. The next task for the researchers will be to increase the sensitivity of the synthetic molecule to ensure that it can be used to bind to very specific DNA sequences and thus be used as a more precise tool. Currently the synthetic molecule se...