Research to Prevent Blindness awards $4.8 million
...keratoconjunctivitis (a severe and chronic form of ocular allergy that causes blindness in 70% of those who suffer from it); the study of possible relationships between optic nerve size, eyeball shape and focus error and the development of amblyopia (lazy eye); and an attempt to create three-dimensional ima...JCI Table of Contents, 15 July 2004
...haracteristics are aortic aneurysm and dissection, ocular lens dislocation, and long bone overgrowth. In 1991, a mutation in a gene called fibrillin-1 was identified as the cause of the disease. At that time many felt that the molecular impact of this mutation in disease development could be explained by wh...Chlamydiae infection may be associated with ocular adnexal lymphoma
... are several similarities between the pathology of ocular adnexal lymphoma, a type of cancer that affects th... trachomatis, C. pneumoniae , or C. psittaci and ocular adnexal lymphoma, Andrs J. M. Ferreri, M.D., of the San Raffaele H Scientific Institute in Milan, It...JCI table of contents, 2 April 2004
... chronic inflammatory disorders, and most blinding ocular diseases. The VEGF family of growth factors is a key contributor to these processes. Previous studies indicated that VEGF-A is primarily responsible for hemangiogenesis, whereas VEGF-C and -D induce lymphangiogenesis. Whether VEGF-A also plays a role...OXiGENE launches significant expansion of its R&D program in ophthalmology
...nical studies involving mouse and rabbit models of ocular disease conducted at leading research institutions...hers have seen with CA4P in their animal models of ocular neovascularization," said Dai Chaplin, Ph.D., OXiGENE's head of research and chief scientific office...Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
...ic stimulus, CA-4-P can prevent these two forms of ocular neovascularization. A recent study has shown that CA-4-P can also prevent ischemia-induced retinal neovascularization in mice. Therefore, CA-4-P joins a growing list of drugs that have potential as prophylactic agents for retinal and/or choroidal n...Study sheds light on critical relay in visual circuit of the brain
...these columns. One type of column, for determining ocular dominance, forms based on visual signals it receiv...e layer 4 neurons, but without it, the distinctive ocular dominance and orientation columns do not form. "Basically, taking out the subplate arrests cortical ...OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
...ated in mouse and rabbit models as a treatment for ocular disease. The results of these studies suggest that CA4P may block the development and, most importantly, promote regression of choroidal neovascularization. In addition to the wet AMD trial announced today, CA4P is being studied in four clinical tr...JCI table of contents, 2 June, 2003
...at the correlation between the preferred location ocular versus genital of this organism is linked to the ...n synthase genes differentiate between genital and ocular isolates AUTHOR CONTACT: Grant McClarty University of Manitoba, Winnipeg, Manitoba, Canada. Phone: (...Gene mutation exacerbates eye defect in inherited glaucoma
...ng the mice, the scientists found malformations of ocular drainage structures that normally control pressure...ice also showed more severe abnormalities in their ocular drainage system. To determine whether administering L-DOPA might alleviate these defects, the resear...Researchers identify new gene mutation in glaucoma
...ng the mice, the scientists found malformations of ocular drainage structures that normally control pressure...ice also showed more severe abnormalities in their ocular drainage system. To determine whether administering L-DOPA might alleviate these defects, the resear...New hope for preventing major problems of the retina
...unctions in the eye are complex and affect several ocular tissues. These include transmitter effects and imp...ntraocular (within the eyeball) pressure (IOP) and ocular blood flow. It is known from several tissues that vascular effects of dopamine are not only mediated...OXiGENE announces commencement of Phase I/II clinical trial of Combretastatin A4 Prodrug
...n application in the treatment of certain forms of ocular disease and other conditions. OXiGENE is using its proprietary vascular targeting technology to develop new drugs that will enhance the effectiveness of traditional cancer treatments and to introduce innovative therapies that attack cancer and other ...Secretary Abraham announces next steps for artificial retina project
...ic testing of electrode arrays and develop special ocular sensors. Lawrence Livermore and Sandia National Laboratories are developing advanced electrodes. Los Alamos National Laboratory will provide advanced optical imaging techniques. Working in collaboration with Second Sight LLC, Argonne National Lab ...Fish profiling to stop ANS; dye test for fish disease; reauthorization
...so has been used as a trace in clinical studies of ocular blood flow or angiography. The use of this test would be particularly important for the aquaculture industry where fish are reared under very high stocking densities, offering potential for disease outbreaks. In North Carolina alone, aquaculture ent...Adult stem cells selectively delivered into the eye and used to control angiogenesis at TSRI
...in the first instance, and in the second, to treat ocular diseases resulting from abnormal retinal angiogene...tested these stem cells in a mouse model system of ocular disease. In normal mice, retinal blood vesssels form during the first three weeks after birth. In th...Making sense of Marfan syndrome
...cts the skeletal, respiratory, cardiovascular, and ocular systems, and is commonly associated with tall stature and markedly long limbs. In 1991 scientists discovered that Marfan syndrome is caused by mutations in the fibrillin 1 (FBN1) gene. Now, more than a decade later, Dr. Beemon and colleagues are len...Americans lack knowledge of ocular hypertension
...ten Incorporated found that only 27% have heard of ocular hypertension, a generally symptomless condition th...r to glaucoma. Only 7% of those who were aware of ocular hypertension know that it has no symptoms. Additionally, only 29% of the group at increased risk fo...Leptospirosis raising health concern among companion animal owners
... be relatively mild and include flu-like symptoms, ocular pain, redness of the eyes, nasal discharge, fever, or muscle and joint pain; however, it can progress to more severe kidney and liver failure. Harkin likens contracting the disease to being "hit by a truck." "I've actually talked to people who have s...Sleep in early life may play crucial role in brain development
...es a rapid remodeling of neural circuitry known as ocular dominance plasticity. The researchers then examined the impact of sleep on the long-term effects of those changes by using brain imaging and making electrical recordings from brain cells. First, in one set of cats they took a measurement of the brain...