Prion propagation: Avoiding the toxic oligomer
...ther amyloids follow a progression from monomer to oligomer to plaque. Using the yeast prion protein Sup35 to ...onditions that favor fiber growth while inhibiting oligomer formation might limit the toxic effects of amyloid plaques. The approaches outlined here should lay ...An alternative form of chemotherapy? A means for reusable spacecraft?
...to human health. She has created a beta-amino acid oligomer that kills both gram positive and gram negative bacteria (including strains which are resistant to common antibiotics) without harming human red blood cells. This peptide and related compounds may represent a new type of chemotherapy treatment for b......" In Science, Dr.Patel and his team describe an oligomer of dopamine and somatostatin receptors which can be activated to a certain level by either somatostatin or dopamine but which produces a synergistic response when the two ligands are applied simultaneously. "When the complex is exposed to a d......rocesses, the researchers produce cyclic polyester oligomer molecules that are polymerized using an organo-tin or organo-titanate catalyst to form a material that can be either a powder or liquid at room temperature. Once applied to a surface, the coating is cured using heat or ultraviolet light...